eF-site ID 2zjp-XZ PDB Code 2zjp Chain X, Z click to enlarge Title Thiopeptide antibiotic Nosiheptide bound to the large ribosomal subunit of Deinococcus radiodurans Classification RIBOSOME/ANTIBIOTIC Compound 50S RIBOSOMAL PROTEIN L33 Source ORGANISM_SCIENTIFIC: DEINOCOCCUS RADIODURANS; Sequence X:  GGUCAAGAUAGUAAGGGUCCACGGUGGAUGCCCUGGCGCU GGAGCCGAUGAAGGACGCGAUUACCUGCGAAAAGCCCCGA CGAGCUGGAGAUACGCUUUGACUCGGGGAUGUCCGAAUGG GGAAACCCACCUCGUAAGAGGUAUCCGCAAGGAUGGGAAC UCAGGGAACUGAAACAUCUCAGUACCUGAAGGAGAAGAAA GAGAAUUCGAUUCCGUUAGUAGCGGCGAGCGAACCCGGAU CAGCCCAAUCAAGCCGAAGUGGCUGGAAAGCUACACCUCA GAAGGUGAGAGUCCUGUAGGCGAACGAGAGGUCGUUGUUC GUGAAACGAUGACUGAAUCCGCGCGGACCACCGCGCAAGG CUAAAUACUCCCAGUGACCGAUAGCGCAUAGUACCGUGAG GGAAAGGUGAAAAGAACCCCGGGAGGGGAGUGAAAGAGAA CCUGAAACCGUGGACUUACAAGCAGUCAUGGCACCUUAUG CGUGUUAUGGCGUGCCUAUUGAAGCAUGAGCCGGCGACUU AGACCUGACGUGCGAGCUUAAGUUGAAAAACGGAGGCGGA GCGAAAGCGAGUCCGAAUAGGGCGGCAUUAGUACGUCGGG CUAGACUCGAAACCAGGUGAGCUAAGCAUGACCAGGUUGA AACCCCCGUGACAGGGGGCGGAGGACCGAACCGGUGCCUG CUGAAACAGUCUCGGAUGAGUUGUGUUUAGGAGUGAAAAG CUAACCGAACCUGGAGAUAGCUAGUUCUCCCCGAAAUGUA UUGAGGUACAGCCUCGGAUGUUGACCAUGUCCUGUAGAGC ACUCACAAGGCUAAAACCUUAUGAAACUCCGAAGGGGCAC GCGUUUAGUCCGGGAGUGAGGCUGCGAGAGCUAACUUCCG UAGCCGAGAGGGAAACAACCCAGACCAUCAGCUAAGGUCC CUAAAUGAUCGCUCAGUGGUUAAGGAUGUGUCGUCGCAUA GACAGCCAGGAGGUUGGCUUAGAAGCAGCCACCCUUCAAA GAGUGCGUAAUAGCUCACUGGUCGAGUGACGAUGCGCCGA AAAUGAUCGGGGCUCAAGUGAUCUACCGAAGCUAUGGAUU CAACUCGCGAAGCGAGUUGUCUGGUAGGGGAGCGUUCAGU CCGCGGAGAAGCCAUACCGGAAGGAGUGGUGGAGCCGACU GAAGUGCGGAUGCCGGCAUGAGUAACGAUAAAAGAAGUGA GAAUCUUCUUCGCCGUAAGGACAAGGGUUCCUGGGGAAGG GUCGUCCGCCCAGGGAAAGUCGGGACCUAAGGUGAGGCCG AACGGCGCAGCCGAUGGACAGCAGGUCAAGAUUCCUGCAC CGAUCAUGUGGAGUGAUGGAGGGACGCAUUACGCUAUCCA AUGCCAAGCUAUGGCUAUGCUGGUUGGUACGCUCAAGGGC GAUCGGGUCAGAAAAUCUACCGGUCACAUGCCUCAGACGU AUCGGGAGCUUCCUCGGAAGCGAAGUUGGAAACGCGACGG UGCCAAGAAAAGCUUCUAAACGUUGAAACAUGAUUGCCCG UACCGCAAACCGACACAGGUGUCCGAGUGUCAAUGCACUA AGGCGCGCGAGAGAACCCUCGUUAAGGAACUUUGCAAUCU CACCCCGUAACUUCGGAAGAAGGGGUCCCCACGCUUCGCG UGGGGCGCAGUGAAUAGGCCCAGGCGACUGUUUACCAAAA UCACAGCACUCUGCCAACACGAACAGUGGACGUAUAGGGU GUGACGCCUGCCCGGUGCCGGAAGGUCAAGUGGAGCGGUG CAAGCUGCGAAAUGAAGCCCCGGUGAACGGCUAAGGUAGC GAAAUUCCUUGUCGGGUAAGUUCCGACCUGCACGAAAGGC GUAACGAUCUGGGCGCUGUCUCAACGAGGGACUCGGUGAA AUUGAAUUGGCUGUAAAGAUGCGGCCUACCCGUAGCAGGA CGAAAAGACCCCGUGGAGCUUUACUAUAGUCUGGCAUUGG GAUUCGGGUUUCUAGAAACUUGGAUUUCUAACCUGAAAAA UCACUUUCGGGGACCGUGCUUGGCGGGUAGUUUGACUGGG GCGGUCGCCUCCCAAAAUGUAACGGAGGCGCCCAAAGGUC ACCUCAAGACGGUUGGAAAUCGUCUGUAGAGCGCAAAGGU AGAAGGUGGCUUGACUGCGAGACUGACACGUCGAGCAGGG AGGAAACUCGGGCUUAGUGAACCGGUGGUACCGUGUGGAA GGGCCAUCGAUCAACGGAUAAAAGUUACCCCGGGGAUAAC AGGCUGAUCUCCCCCGAGAGUCCAUAUCGGCGGGGAGGUU UGGCACCUCGAUGUCGGCUCGUCGCAUCCUGGGGCUGAAG AAGGUCCCAAGGGUUGGGCUGUUCGCCCAUUAAAGCGGCA CGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCUC UAUCCGCUACGGGCGCAGGAGAAUUGAGGGGAGUUGCUCC UAGUACGAGAGGACCGGAGUGAACGGACCGCUGGUCUCCC UGCUGUCGUACCAACGGCACAUGCAGGGUAGCUAUGUCCG GAACGGAUAACCGCUGAAAGCAUCUAAGCGGGAAGCCAGC CCCAAGAUGAGUUCUCCCACUGUUUAUCAGGUAAGACUCC CGGAAGACCACCGGGUUAAGAGGCCAGGCGUGCACGCAUA GCAAUGUGUUCAGCGGACUGGUGCUCAUCAGUCGAGGUCU UGACCA Z:  CACCCCCGUGCCCAUAGCACUGUGGAACCACCCCACCCCA UGCCGAACUGGGUCGUGAAACACAGCAGCGCCAAUGAUAC UCGGACCGCAGGGUCCCGGAAAAGUCGGUCAGCGCGGGGG UU Description Functional site 1) chain X residue 2057 type sequence U description BINDING SITE FOR RESIDUE MG X 2881 source : AC3 2) chain X residue 2058 type sequence U description BINDING SITE FOR RESIDUE MG X 2881 source : AC3 3) chain X residue 2415 type sequence G description BINDING SITE FOR RESIDUE MG X 2882 source : AC4 4) chain X residue 1369 type sequence G description BINDING SITE FOR RESIDUE MG X 2883 source : AC5 5) chain X residue 1370 type sequence U description BINDING SITE FOR RESIDUE MG X 2883 source : AC5 6) chain X residue 746 type sequence G description BINDING SITE FOR RESIDUE MG X 2884 source : AC6 7) chain X residue 747 type sequence A description BINDING SITE FOR RESIDUE MG X 2884 source : AC6 8) chain X residue 774 type sequence A description BINDING SITE FOR RESIDUE MG X 2884 source : AC6 9) chain X residue 745 type sequence C description BINDING SITE FOR RESIDUE MG X 2885 source : AC7 10) chain X residue 772 type sequence G description BINDING SITE FOR RESIDUE MG X 2885 source : AC7 11) chain X residue 1767 type sequence G description BINDING SITE FOR RESIDUE MG X 2886 source : AC8 12) chain X residue 1765 type sequence C description BINDING SITE FOR RESIDUE MG X 2887 source : AC9 13) chain X residue 2557 type sequence G description BINDING SITE FOR RESIDUE MG X 2888 source : BC1 14) chain X residue 2743 type sequence G description BINDING SITE FOR RESIDUE MG X 2889 source : BC2 15) chain X residue 2036 type sequence G description BINDING SITE FOR RESIDUE MG X 2890 source : BC3 16) chain X residue 2555 type sequence G description BINDING SITE FOR RESIDUE MG X 2890 source : BC3 17) chain X residue 2556 type sequence A description BINDING SITE FOR RESIDUE MG X 2890 source : BC3 18) chain X residue 1980 type sequence A description BINDING SITE FOR RESIDUE MG X 2894 source : BC4 19) chain X residue 2665 type sequence G description BINDING SITE FOR RESIDUE MG X 2895 source : BC5 20) chain X residue 2666 type sequence U description BINDING SITE FOR RESIDUE MG X 2895 source : BC5 21) chain X residue 2700 type sequence U description BINDING SITE FOR RESIDUE MG X 2895 source : BC5 22) chain X residue 2699 type sequence G description BINDING SITE FOR RESIDUE MG X 2896 source : BC6 23) chain X residue 815 type sequence A description BINDING SITE FOR RESIDUE MG X 2897 source : BC7 24) chain X residue 1760 type sequence G description BINDING SITE FOR RESIDUE MG X 2900 source : BC8 25) chain X residue 1761 type sequence G description BINDING SITE FOR RESIDUE MG X 2900 source : BC8 26) chain X residue 1941 type sequence C description BINDING SITE FOR RESIDUE MG X 2900 source : BC8 27) chain X residue 1266 type sequence G description BINDING SITE FOR RESIDUE MG X 2903 source : BC9 28) chain X residue 461 type sequence A description BINDING SITE FOR RESIDUE MG X 2904 source : CC1 29) chain X residue 462 type sequence G description BINDING SITE FOR RESIDUE MG X 2904 source : CC1 30) chain X residue 464 type sequence G description BINDING SITE FOR RESIDUE MG X 2904 source : CC1 31) chain X residue 463 type sequence C description BINDING SITE FOR RESIDUE MG X 2905 source : CC2 32) chain X residue 465 type sequence C description BINDING SITE FOR RESIDUE MG X 2905 source : CC2 33) chain X residue 467 type sequence U description BINDING SITE FOR RESIDUE MG X 2905 source : CC2 34) chain X residue 2431 type sequence C description BINDING SITE FOR RESIDUE MG X 2907 source : CC3 35) chain X residue 2564 type sequence U description BINDING SITE FOR RESIDUE MG X 2907 source : CC3 36) chain X residue 2480 type sequence C description BINDING SITE FOR RESIDUE MG X 2908 source : CC4 37) chain Z residue 99 type sequence G description BINDING SITE FOR RESIDUE MG Z 124 source : CC6 38) chain Z residue 100 type sequence G description BINDING SITE FOR RESIDUE MG Z 124 source : CC6 39) chain Z residue 105 type sequence G description BINDING SITE FOR RESIDUE MG Z 127 source : CC7 40) chain X residue 1078 type sequence A description BINDING SITE FOR LINKED RESIDUES 5 1 to 14 source : CC8 41) chain X residue 1079 type sequence G description BINDING SITE FOR LINKED RESIDUES 5 1 to 14 source : CC8 42) chain X residue 1106 type sequence A description BINDING SITE FOR LINKED RESIDUES 5 1 to 14 source : CC8 43) chain X residue 1107 type sequence A description BINDING SITE FOR LINKED RESIDUES 5 1 to 14 source : CC8

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