eF-site ID 2zhx-ABCDEFGHIJKLMN PDB Code 2zhx Chain A, B, C, D, E, F, G, H, I, J, K, L, M, N click to enlarge Title Crystal structure of Uracil-DNA Glycosylase from Mycobacterium tuberculosis in complex with a proteinaceous inhibitor Classification HYDROLASE/HYDROLASE INHIBITOR Compound Uracil-DNA glycosylase Source (UNGI_BPPB2) Sequence A:  ARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRY LPAGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFS VAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQRG VLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAP LVAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFF GSRPFSRANELLVGMGAEPIDWRLP B:  NLSDIIEKETGKQLVIQESILMLPEEVEEVIGNKPESDIL VHTAYDESTDENVMLLTSDAPEYKPWALVIQDSNGENKIK ML C:  ARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRY LPAGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFS VAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQRG VLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAP LVAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFF GSRPFSRANELLVGMGAEPIDWRLP D:  NLSDIIEKETGKQLVIQESILMLPEEVEEVIGNKPESDIL VHTAYDESTDENVMLLTSDAPEYKPWALVIQDSNGENKIK ML E:  RPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRYL PAGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFSV APDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQRGV LLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAPL VAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFFG SRPFSRANELLVGMGAEPIDWRLP F:  NLSDIIEKETGKQLVIQESILMLPEEVEEVIGNKPESDIL VHTAYDESTDENVMLLTSDAPEYKPWALVIQDSNGENKIK ML G:  ARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRY LPAGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFS VAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQRG VLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAP LVAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFF GSRPFSRANELLVGMGAEPIDWRLP H:  NLSDIIEKETGKQLVIQESILMLPEEVEEVIGNKPESDIL VHTAYDESTDENVMLLTSDAPEYKPWALVIQDSNGENKIK ML I:  ARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRY LPAGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFS VAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQRG VLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAP LVAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFF GSRPFSRANELLVGMGAEPIDWRLP J:  NLSDIIEKETGKQLVIQESILMLPEEVEEVIGNKPESDIL VHTAYDESTDENVMLLTSDAPEYKPWALVIQDSNGENKIK ML K:  ARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRY LPAGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFS VAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQRG VLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAP LVAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFF GSRPFSRANELLVGMGAEPIDWRLP L:  NLSDIIEKETGKQLVIQESILMLPEEVEEVIGNKPESDIL VHTAYDESTDENVMLLTSDAPEYKPWALVIQDSNGENKIK ML M:  ARPLSELVERGWAAALEPVADQVAHMGQFLRAEIAAGRRY LPAGSNVLRAFTFPFDNVRVLIVGQDPYPTPGHAVGLSFS VAPDVRPWPRSLANIFDEYTADLGYPLPSNGDLTPWAQRG VLLLNRVLTVRPSNPASHRGKGWEAVTECAIRALAARAAP LVAILWGRDASTLKPMLAAGNCVAIESPHPSPLSASRGFF GSRPFSRANELLVGMGAEPIDWRLP N:  NLSDIIEKETGKQLVIQESILMLPEEVEEVIGNKPESDIL VHTAYDESTDENVMLLTSDAPEYKPWALVIQDSNGENKIK ML Description Functional site 1) chain A residue 68 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 2) chain C residue 68 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 3) chain E residue 68 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 4) chain G residue 68 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 5) chain I residue 68 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 6) chain K residue 68 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 7) chain M residue 68 type ACT_SITE sequence D description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 8) chain A residue 61-70 type prosite sequence RVLIVGQDPY description U_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. RVLIvGQDPY source prosite : PS00130

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