eF-site ID 2zev-AB PDB Code 2zev Chain A, B click to enlarge Title S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Magnesium, IPP and BPH-715 Classification TRANSFERASE Compound Geranylgeranyl pyrophosphate synthetase Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (GGPPS_YEAST) Sequence A:  NKMEAKIDELINNDPVWSSQNESLISKPYNHILLKRLNLI VQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPL RRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEPL YHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMYL NMVMNKTGGLFRLTLRLMEALSPSGHSLVPFINLLGIIYQ IRDDYLNLKDFQMFAEDITEGKLSFPIVHALNFTKTKGQT EQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNF INQLVNMIKNDNENKYLP B:  KMEAKIDELINNDPVWSSQNESLISKPYNHILLKNFRLNL IVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAP LRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLTTKEP LYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPTQEMY LNMVMNKTGGLFRLTLRLMEALSPSHSLVPFINLLGIIYQ IRDDYLNLKDFQMGFAEDITEGKLSFPIVHALNFTKTKGQ TEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKN FINQLVNMIKNDNENKYLP Description Functional site 1) chain A residue 80 type sequence D description BINDING SITE FOR RESIDUE MG A1301 source : AC1 2) chain A residue 84 type sequence D description BINDING SITE FOR RESIDUE MG A1301 source : AC1 3) chain A residue 80 type sequence D description BINDING SITE FOR RESIDUE MG A1302 source : AC2 4) chain A residue 84 type sequence D description BINDING SITE FOR RESIDUE MG A1302 source : AC2 5) chain B residue 80 type sequence D description BINDING SITE FOR RESIDUE MG B1303 source : AC3 6) chain B residue 84 type sequence D description BINDING SITE FOR RESIDUE MG B1303 source : AC3 7) chain B residue 80 type sequence D description BINDING SITE FOR RESIDUE MG B1304 source : AC4 8) chain B residue 84 type sequence D description BINDING SITE FOR RESIDUE MG B1304 source : AC4 9) chain B residue 147 type sequence Q description BINDING SITE FOR RESIDUE MG B1304 source : AC4 10) chain A residue 69 type sequence V description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 11) chain A residue 73 type sequence H description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 12) chain A residue 80 type sequence D description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 13) chain A residue 84 type sequence D description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 14) chain A residue 89 type sequence R description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 15) chain A residue 143 type sequence L description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 16) chain A residue 147 type sequence Q description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 17) chain A residue 174 type sequence K description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 18) chain A residue 175 type sequence T description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 19) chain A residue 179 type sequence F description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 20) chain A residue 182 type sequence T description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 21) chain A residue 210 type sequence Y description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 22) chain A residue 211 type sequence Q description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 23) chain A residue 214 type sequence D description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 24) chain A residue 238 type sequence K description BINDING SITE FOR RESIDUE B71 A1201 source : AC5 25) chain B residue 38 type sequence K description BINDING SITE FOR RESIDUE IPE B1102 source : AC6 26) chain B residue 44 type sequence R description BINDING SITE FOR RESIDUE IPE B1102 source : AC6 27) chain B residue 73 type sequence H description BINDING SITE FOR RESIDUE IPE B1102 source : AC6 28) chain B residue 77 type sequence L description BINDING SITE FOR RESIDUE IPE B1102 source : AC6 29) chain B residue 210 type sequence Y description BINDING SITE FOR RESIDUE IPE B1102 source : AC6 30) chain B residue 211 type sequence Q description BINDING SITE FOR RESIDUE IPE B1102 source : AC6 31) chain B residue 44 type sequence R description BINDING SITE FOR RESIDUE B71 B1202 source : AC7 32) chain B residue 47 type sequence L description BINDING SITE FOR RESIDUE B71 B1202 source : AC7 33) chain B residue 73 type sequence H description BINDING SITE FOR RESIDUE B71 B1202 source : AC7 34) chain B residue 80 type sequence D description BINDING SITE FOR RESIDUE B71 B1202 source : AC7 35) chain B residue 84 type sequence D description BINDING SITE FOR RESIDUE B71 B1202 source : AC7 36) chain B residue 89 type sequence R description BINDING SITE FOR RESIDUE B71 B1202 source : AC7 37) chain B residue 143 type sequence L description BINDING SITE FOR RESIDUE B71 B1202 source : AC7 38) chain B residue 147 type sequence Q description BINDING SITE FOR RESIDUE B71 B1202 source : AC7 39) chain B residue 174 type sequence K description BINDING SITE FOR RESIDUE B71 B1202 source : AC7 40) chain B residue 179 type sequence F description BINDING SITE FOR RESIDUE B71 B1202 source : AC7 41) chain B residue 211 type sequence Q description BINDING SITE FOR RESIDUE B71 B1202 source : AC7 42) chain B residue 214 type sequence D description BINDING SITE FOR RESIDUE B71 B1202 source : AC7 43) chain B residue 238 type sequence K description BINDING SITE FOR RESIDUE B71 B1202 source : AC7 44) chain A residue 112 type SITE sequence Y description Important for determining product chain length source Swiss-Prot : SWS_FT_FI4 45) chain B residue 112 type SITE sequence Y description Important for determining product chain length source Swiss-Prot : SWS_FT_FI4 46) chain A residue 206-218 type prosite sequence LGIIYQIRDDYLN description POLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. LGiiYQIrDDYlN source prosite : PS00444 47) chain A residue 77-91 type prosite sequence LLIDDIEDNAPLRRG description POLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LLiDDie..DnaplRRG source prosite : PS00723 48) chain A residue 238 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 49) chain B residue 44 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 50) chain B residue 73 type BINDING sequence H description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 51) chain B residue 89 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 52) chain B residue 90 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 53) chain B residue 174 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 54) chain B residue 175 type BINDING sequence T description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 55) chain B residue 211 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 56) chain B residue 218 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 57) chain A residue 44 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 58) chain B residue 238 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 59) chain A residue 73 type BINDING sequence H description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 60) chain A residue 89 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 61) chain A residue 90 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 62) chain A residue 174 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 63) chain A residue 175 type BINDING sequence T description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 64) chain A residue 211 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 65) chain A residue 218 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 66) chain A residue 80 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16554305, ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI2 67) chain A residue 84 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16554305, ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI2 68) chain B residue 80 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16554305, ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI2 69) chain B residue 84 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16554305, ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI2

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