eF-site ID 2z9k-B PDB Code 2z9k Chain B click to enlarge Title Complex structure of SARS-CoV 3C-like protease with JMF1600 Classification HYDROLASE Compound 3C-like proteinase Source Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) (R1AB_CVHSA) Sequence B:  SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPR HVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGH SMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFC YMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTI TLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT ILGSTILEDEFTPFDVVRQCSGVTFQ Description Functional site 1) chain B residue 140 type sequence F description BINDING SITE FOR RESIDUE DMS B 802 source : AC1 2) chain B residue 141 type sequence L description BINDING SITE FOR RESIDUE DMS B 802 source : AC1 3) chain B residue 142 type sequence N description BINDING SITE FOR RESIDUE DMS B 802 source : AC1 4) chain B residue 145 type sequence C description BINDING SITE FOR RESIDUE DMS B 802 source : AC1 5) chain B residue 163 type sequence H description BINDING SITE FOR RESIDUE DMS B 802 source : AC1 6) chain B residue 166 type sequence E description BINDING SITE FOR RESIDUE DMS B 802 source : AC1 7) chain B residue 172 type sequence H description BINDING SITE FOR RESIDUE DMS B 802 source : AC1 8) chain B residue 6 type sequence M description BINDING SITE FOR RESIDUE DMS B 812 source : AC3 9) chain B residue 7 type sequence A description BINDING SITE FOR RESIDUE DMS B 812 source : AC3 10) chain B residue 127 type sequence Q description BINDING SITE FOR RESIDUE DMS B 812 source : AC3 11) chain B residue 298 type sequence R description BINDING SITE FOR RESIDUE DMS B 812 source : AC3 12) chain B residue 123 type sequence S description BINDING SITE FOR RESIDUE DMS A 813 source : AC4 13) chain B residue 41 type sequence H description BINDING SITE FOR RESIDUE DOZ B 902 source : AC6 14) chain B residue 145 type sequence C description BINDING SITE FOR RESIDUE DOZ B 902 source : AC6 15) chain B residue 164 type sequence H description BINDING SITE FOR RESIDUE DOZ B 902 source : AC6 16) chain B residue 41 type catalytic sequence H description 830 source MCSA : MCSA2 17) chain B residue 143 type catalytic sequence G description 830 source MCSA : MCSA2 18) chain B residue 145 type catalytic sequence C description 830 source MCSA : MCSA2 19) chain B residue 41 type ACT_SITE sequence H description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 145 type ACT_SITE sequence C description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 306 type SITE sequence Q description Cleavage; by 3CL-PRO => ECO:0000269|PubMed:14561748 source Swiss-Prot : SWS_FT_FI2

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