eF-site ID 2z9k-A PDB Code 2z9k Chain A click to enlarge Title Complex structure of SARS-CoV 3C-like protease with JMF1600 Classification HYDROLASE Compound 3C-like proteinase Source Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) (R1AB_CVHSA) Sequence A:  SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPR HVICTAEDMLNPNYEDLLIRKSNHSFLVQAGNVQLRVIGH SMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFC YMHHMELPTGVHAGTDLEGKFYGPFVDRQTAQAAGTDTTI TLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRT ILGSTILEDEFTPFDVVRQCSGVTF Description Functional site 1) chain A residue 140 type sequence F description BINDING SITE FOR RESIDUE DMS A 803 source : AC2 2) chain A residue 141 type sequence L description BINDING SITE FOR RESIDUE DMS A 803 source : AC2 3) chain A residue 142 type sequence N description BINDING SITE FOR RESIDUE DMS A 803 source : AC2 4) chain A residue 145 type sequence C description BINDING SITE FOR RESIDUE DMS A 803 source : AC2 5) chain A residue 163 type sequence H description BINDING SITE FOR RESIDUE DMS A 803 source : AC2 6) chain A residue 166 type sequence E description BINDING SITE FOR RESIDUE DMS A 803 source : AC2 7) chain A residue 172 type sequence H description BINDING SITE FOR RESIDUE DMS A 803 source : AC2 8) chain A residue 123 type sequence S description BINDING SITE FOR RESIDUE DMS B 812 source : AC3 9) chain A residue 6 type sequence M description BINDING SITE FOR RESIDUE DMS A 813 source : AC4 10) chain A residue 7 type sequence A description BINDING SITE FOR RESIDUE DMS A 813 source : AC4 11) chain A residue 8 type sequence F description BINDING SITE FOR RESIDUE DMS A 813 source : AC4 12) chain A residue 127 type sequence Q description BINDING SITE FOR RESIDUE DMS A 813 source : AC4 13) chain A residue 298 type sequence R description BINDING SITE FOR RESIDUE DMS A 813 source : AC4 14) chain A residue 27 type sequence L description BINDING SITE FOR RESIDUE DOZ A 901 source : AC5 15) chain A residue 41 type sequence H description BINDING SITE FOR RESIDUE DOZ A 901 source : AC5 16) chain A residue 145 type sequence C description BINDING SITE FOR RESIDUE DOZ A 901 source : AC5 17) chain A residue 41 type catalytic sequence H description 830 source MCSA : MCSA1 18) chain A residue 143 type catalytic sequence G description 830 source MCSA : MCSA1 19) chain A residue 145 type catalytic sequence C description 830 source MCSA : MCSA1 20) chain A residue 41 type ACT_SITE sequence H description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 145 type ACT_SITE sequence C description For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772 source Swiss-Prot : SWS_FT_FI1

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