eF-site ID 2z78-B PDB Code 2z78 Chain B click to enlarge Title S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with BPH-806 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Geranylgeranyl pyrophosphate synthetase Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (GGPPS_YEAST) Sequence B:  NKMEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNF RLNLIVQINRVMNLPKDQLAIVSQIVELLHNSSLLIDDIE DNAPLRRGQTTSHLIFGVPSTINTANYMYFRAMQLVSQLT TKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPEIIPT QEMYLNMVMNKTGGLFRLTLRLMEALSPSSHSLVPFINLL GIIYQIRDDYLNLKDFQMSGFAEDITEGKLSFPIVHALNF TKTKGQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNS LAYTKNFINQLVNMIKNDNENKYLPELLYIIDHLSEL Description Functional site 1) chain B residue 47 type sequence L description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 2) chain B residue 73 type sequence H description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 3) chain B residue 76 type sequence S description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 4) chain B residue 77 type sequence L description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 5) chain B residue 80 type sequence D description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 6) chain B residue 89 type sequence R description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 7) chain B residue 143 type sequence L description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 8) chain B residue 147 type sequence Q description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 9) chain B residue 174 type sequence K description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 10) chain B residue 178 type sequence L description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 11) chain B residue 182 type sequence T description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 12) chain B residue 210 type sequence Y description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 13) chain B residue 211 type sequence Q description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 14) chain B residue 214 type sequence D description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 15) chain B residue 238 type sequence K description BINDING SITE FOR RESIDUE H86 B 1301 source : AC2 16) chain B residue 112 type SITE sequence Y description Important for determining product chain length source Swiss-Prot : SWS_FT_FI4 17) chain B residue 41 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 44 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 73 type BINDING sequence H description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 89 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 90 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 174 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 175 type BINDING sequence T description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 211 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 218 type BINDING sequence N description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 238 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 80 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16554305, ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 84 type BINDING sequence D description BINDING => ECO:0000269|PubMed:16554305, ECO:0000269|PubMed:17535895 source Swiss-Prot : SWS_FT_FI2

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