eF-site ID 2z3w-A PDB Code 2z3w Chain A click to enlarge Title Prolyl tripeptidyl aminopeptidase mutant E636A Classification HYDROLASE Compound Dipeptidyl aminopeptidase IV Source Porphyromonas gingivalis (strain ATCC BAA-308 / W83) (Q7MUW6_PORGI) Sequence A:  YVVGLQWMGDNYVFIEGDDLVFNKTTRFSAADLNALMPEF PSFRTLDAGRGLVVLFTQGGLVGFDMLARKVTYLFDTNEE TASLDFSPVGDRVAYVRNHNLYIARGGKLGEGMSRAIAVT IDGTETLVYGQAVHQREFGIEKGTFWSPKGSCLAFYRMDQ SMVKPTPIVDYHPLEAESKPLYYPMAGTPSHHVTVGIYHL ATGKTVYLQTGEPKEKFLTNLSWSPDENILYVAEVNRAQN ECKVNAYDAETGRFVRTLFVETDKHYVEPLHPLTFLPGSN NQFIWQSRRDGWNHLYLYDTTGRLIRQVTKGEWEVTNFAG FDPKGTRLYFESTEASPLERHFYCIDIKGGKTKDLTPESG MHRTQLSPDGSAIIDIFQSPTVPRKVTVTNIGKGSHTLLE AKAMPEIRTGTIMAADGQTPLYYKLTMPLHFDPAKKYPVI VYVYGGPHAQLVTKTWRGGWDIYMAQKGYAVFTVDSRGSA NRGAAFEQVIHRRLGQTEMADQMCGVDFLKSQSWVDADRI GVHGWSYGGFMTTNLMLTHGDVFKVGVAGGPVIDWNRYAI MYGERYFDAPQENPEGYDAANLLKRAGDLKGRLMLIHGAI DPVVVWQHSLLFLDACVKARTYPDYYVYPSHEHNVMGPDR VHLYETITRYFTDHL Description Functional site 1) chain A residue 321 type sequence R description BINDING SITE FOR RESIDUE SO4 A 902 source : AC1 2) chain A residue 347 type sequence S description BINDING SITE FOR RESIDUE SO4 A 902 source : AC1 3) chain A residue 349 type sequence N description BINDING SITE FOR RESIDUE SO4 A 902 source : AC1 4) chain A residue 350 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 902 source : AC1 5) chain A residue 518 type sequence Y description BINDING SITE FOR RESIDUE GOL A 901 source : AC2 6) chain A residue 603 type sequence S description BINDING SITE FOR RESIDUE GOL A 901 source : AC2 7) chain A residue 604 type sequence Y description BINDING SITE FOR RESIDUE GOL A 901 source : AC2 8) chain A residue 635 type sequence Y description BINDING SITE FOR RESIDUE GOL A 901 source : AC2 9) chain A residue 639 type sequence Y description BINDING SITE FOR RESIDUE GOL A 901 source : AC2 10) chain A residue 681 type sequence V description BINDING SITE FOR RESIDUE GOL A 901 source : AC2 11) chain A residue 603 type ACT_SITE sequence S description Charge relay system => ECO:0000250|UniProtKB:Q12884 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 678 type ACT_SITE sequence D description Charge relay system => ECO:0000250|UniProtKB:Q12884 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 710 type ACT_SITE sequence H description Charge relay system => ECO:0000250|UniProtKB:Q12884 source Swiss-Prot : SWS_FT_FI1

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