eF-site ID 2z0p-C PDB Code 2z0p Chain C click to enlarge Title Crystal structure of PH domain of Bruton's tyrosine kinase Classification SIGNALING PROTEIN Compound Tyrosine-protein kinase BTK Source Homo sapiens (Human) (BTK_HUMAN) Sequence C:  AAVILESIFLKRSQQKLNFKKRLFLLTVHKLSYYEYDFER GRRGSKKGSIDVEKITCVETVVPEKNPPPERQIMEQISII ERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYN SDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILEN Description Functional site 1) chain C residue 143 type sequence H description BINDING SITE FOR RESIDUE ZN C 303 source : AC3 2) chain C residue 152 type sequence Y description BINDING SITE FOR RESIDUE ZN C 303 source : AC3 3) chain C residue 154 type sequence C description BINDING SITE FOR RESIDUE ZN C 303 source : AC3 4) chain C residue 155 type sequence C description BINDING SITE FOR RESIDUE ZN C 303 source : AC3 5) chain C residue 165 type sequence C description BINDING SITE FOR RESIDUE ZN C 303 source : AC3 6) chain C residue 12 type sequence K description BINDING SITE FOR RESIDUE 4PT C 503 source : AC7 7) chain C residue 14 type sequence S description BINDING SITE FOR RESIDUE 4PT C 503 source : AC7 8) chain C residue 15 type sequence Q description BINDING SITE FOR RESIDUE 4PT C 503 source : AC7 9) chain C residue 16 type sequence Q description BINDING SITE FOR RESIDUE 4PT C 503 source : AC7 10) chain C residue 17 type sequence K description BINDING SITE FOR RESIDUE 4PT C 503 source : AC7 11) chain C residue 24 type sequence N description BINDING SITE FOR RESIDUE 4PT C 503 source : AC7 12) chain C residue 28 type sequence R description BINDING SITE FOR RESIDUE 4PT C 503 source : AC7 13) chain C residue 39 type sequence Y description BINDING SITE FOR RESIDUE 4PT C 503 source : AC7 14) chain C residue 53 type sequence K description BINDING SITE FOR RESIDUE 4PT C 503 source : AC7 15) chain C residue 28 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10196129 source Swiss-Prot : SWS_FT_FI1 16) chain C residue 39 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:10196129 source Swiss-Prot : SWS_FT_FI1 17) chain C residue 53 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10196129 source Swiss-Prot : SWS_FT_FI1 18) chain C residue 26 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10196129 source Swiss-Prot : SWS_FT_FI1 19) chain C residue 115 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:16644721 source Swiss-Prot : SWS_FT_FI4 20) chain C residue 154 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00432, ECO:0000269|PubMed:10196129, ECO:0000269|PubMed:9218782, ECO:0000269|Ref.48 source Swiss-Prot : SWS_FT_FI2 21) chain C residue 155 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00432, ECO:0000269|PubMed:10196129, ECO:0000269|PubMed:9218782, ECO:0000269|Ref.48 source Swiss-Prot : SWS_FT_FI2 22) chain C residue 165 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00432, ECO:0000269|PubMed:10196129, ECO:0000269|PubMed:9218782, ECO:0000269|Ref.48 source Swiss-Prot : SWS_FT_FI2 23) chain C residue 143 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU00432, ECO:0000269|PubMed:10196129, ECO:0000269|PubMed:9218782, ECO:0000269|Ref.48 source Swiss-Prot : SWS_FT_FI2 24) chain C residue 2 type MOD_RES sequence A description N-acetylalanine => ECO:0000269|Ref.11, ECO:0007744|PubMed:25944712 source Swiss-Prot : SWS_FT_FI3 25) chain C residue 40 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P35991 source Swiss-Prot : SWS_FT_FI5 26) chain C residue 55 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI6

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