eF-site ID 2ywb-ABCD PDB Code 2ywb Chain A, B, C, D click to enlarge Title Crystal structure of GMP synthetase from Thermus thermophilus Classification LIGASE Compound GMP synthase [glutamine-hydrolyzing] Source Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (GUAA_THET8) Sequence A:  MVLVLDFGSQYTRLIARRLRELRAFSLILPGDAPLEEVLK HRPQALILSGGPRSVFDPDAPRPDPRLFSSGLPLLGICYG MQLLAQELGGRVERAEYGKALLTRHEGPLFRGLEGEVQVW MSHQDAVTAPPPGWRVVAETEENPVAAIASPDGRAYGVQF HPEVAHTPKGMQILENFLELAGVKRDWTPEHVLEELLREV RERAGKDRVLLAVSGGVDSSTLALLLAKAGVDHLAVFVDH GLLRLGEREEVEGALRALGVNLLVVDAKERFLKALKGVED PEEKRKIIGREFVAAFSQVARERGPFRFLAQGTLYPDVIE GLPEDLEFELLEPFRLLFKDEVRELALLLGLPDTLRLRHP FPGPGLAVRVLGEVTEERLEILRRADDIFTSLLREWGLYE KVAQALAVLTPVGYVLALRAVTTEDFMTADWARLPLEFLD EAARRITRRVPEIGRVVYDLTSKPPATIEWE B:  MVLVLDFGSQYTRLIARRLRELRAFSLILPGDAPLEEVLK HRPQALILSGGPRSVFDPDAPRPDPRLFSSGLPLLGICYG MQLLAQELGGRVERAYGKALLTRHEGPLFRGLEGEVQVWM SHQDAVTAPPPGWRVVAETEENPVAAIASPDGRAYGVQFH PEVAHTPKGMQILENFLELAGVKRDWTPEHVLEELLREVR ERAGKDRVLLAVSGGVDSSTLALLLAKAGVDHLAVFVDHG LLRLGEREEVEGALRALGVNLLVVDAKERFLKALKGVEDP EEKRKIIGREFVAAFSQVARERGPFRFLAQGTLYPDVIEF ELLEPFRLLFKDEVRELALLLGLPDTLRLRHPFPGPGLAV RVLGEVTEERLEILRRADDIFTSLLREWGLYEKVAQALAV LTPVGYVLALRAVTTEDFMTADWARLPLEFLDEAARRITR RVPEIGRVVYDLTSKPPATIEWE C:  MVLVLDFGSQYTRLIARRLRELRAFSLILPGDAPLEEVLK HRPQALILSGGPRSVFDPDAPRPDPRLFSSGLPLLGICYG MQLLAQELGGRVERAYGKALLTRHEGPLFRGLEGEVQVWM SHQDAVTAPPPGWRVVAETEENPVAAIASPDGRAYGVQFH PEVAHTPKGMQILENFLELAGVKRDWTPEHVLEELLREVR ERAGKDRVLLAVSGGVDSSTLALLLAKAGVDHLAVFVDHG LLRLGEREEVEGALRALGVNLLVVDAKERFLKALKGVEDP EEKRKIIGREFVAAFSQVARERGPFRFLAQGTLYPDVIES AEFELLEPFRLLFKDEVRELALLLGLPDTLRLRHPFPGPG LAVRVLGEVTEERLEILRRADDIFTSLLREWGLYEKVAQA LAVLTPVGYVLALRAVTTEDFMTADWARLPLEFLDEAARR ITRRVPEIGRVVYDLTSKPPATIEWE D:  MVLVLDFGSQYTRLIARRLRELRAFSLILPGDAPLEEVLK HRPQALILSGGPRSVFDPDAPRPDPRLFSSGLPLLGICYG MQLLAQELGGRVERYGKALLTRHEGPLFRGLEGEVQVWMS HQDAVTAPPPGWRVVAETEENPVAAIASPDGRAYGVQFHP EVAHTPKGMQILENFLELAGVKRDWTPEHVLEELLREVRE RAGKDRVLLAVSGGVDSSTLALLLAKAGVDHLAVFVDHGL LRLGEREEVEGALRALGVNLLVVDAKERFLKALKGVEDPE EKRKIIGREFVAAFSQVARERGPFRFLAQGTLYPDVILEF ELLEPFRLLFKDEVRELALLLGLPDTLRLRHPFPGPGLAV RVLGEVTEERLEILRRADDIFTSLLREWGLYEKVAQALAV LTPVGYVLALRAVTTEDFMTADWARLPLEFLDEAARRITR RVPEIGRVVYDLTSKPPATIEWE Description Functional site 1) chain A residue 78 type ACT_SITE sequence C description Nucleophile => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 78 type ACT_SITE sequence C description Nucleophile => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI1 3) chain C residue 78 type ACT_SITE sequence C description Nucleophile => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI1 4) chain D residue 78 type ACT_SITE sequence C description Nucleophile => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 164 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI2 6) chain A residue 166 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI2 7) chain B residue 164 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI2 8) chain B residue 166 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI2 9) chain C residue 164 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI2 10) chain C residue 166 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI2 11) chain D residue 164 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI2 12) chain D residue 166 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 217 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI3 14) chain B residue 217 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI3 15) chain C residue 217 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI3 16) chain D residue 217 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00344 source Swiss-Prot : SWS_FT_FI3

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