eF-site ID 2ypt-H
PDB Code 2ypt
Chain H

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Title Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A) in complex with a synthetic CSIM tetrapeptide from the C-terminus of prelamin A
Classification HYDROLASE/PEPTIDE
Compound CAAX PRENYL PROTEASE 1 HOMOLOG
Source Homo sapiens (Human) (LMNA_HUMAN)
Sequence H:  CSIM
Description (1)  CAAX PRENYL PROTEASE 1 HOMOLOG (E.C.3.4.24.84), PRELAMIN-A/C


Functional site

1) chain H
residue 662
type
sequence S
description BINDING SITE FOR RESIDUE ZN D 600
source : AC3

2) chain H
residue 661
type MOD_RES
sequence C
description Cysteine methyl ester => ECO:0000269|PubMed:8175923, ECO:0000269|PubMed:9030603
source Swiss-Prot : SWS_FT_FI1

3) chain H
residue 661
type LIPID
sequence C
description S-farnesyl cysteine => ECO:0000269|PubMed:8175923, ECO:0000269|PubMed:9030603
source Swiss-Prot : SWS_FT_FI2


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