|
|
eF-site ID
|
2ypt-F |
|
PDB Code
|
2ypt |
|
Chain
|
F |
|
click to enlarge
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Title
|
Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A) in complex with a synthetic CSIM tetrapeptide from the C-terminus of prelamin A |
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Classification
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HYDROLASE/PEPTIDE |
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Compound
|
CAAX PRENYL PROTEASE 1 HOMOLOG |
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Source
|
Homo sapiens (Human) (LMNA_HUMAN) |
|
|
Sequence
|
F: |
CSI
|
|
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Description
|
(1) |
CAAX PRENYL PROTEASE 1 HOMOLOG (E.C.3.4.24.84), PRELAMIN-A/C
|
|
Functional site
|
|
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1)
|
chain |
F |
| residue |
662 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE ZN A 600
|
| source |
: AC1
|
|
|
2)
|
chain |
F |
| residue |
661 |
| type |
MOD_RES |
| sequence |
C
|
| description |
Cysteine methyl ester => ECO:0000269|PubMed:8175923, ECO:0000269|PubMed:9030603
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
F |
| residue |
661 |
| type |
LIPID |
| sequence |
C
|
| description |
S-farnesyl cysteine => ECO:0000269|PubMed:8175923, ECO:0000269|PubMed:9030603
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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