eF-site ID 2ypt-A PDB Code 2ypt Chain A click to enlarge Title Crystal structure of the human nuclear membrane zinc metalloprotease ZMPSTE24 mutant (E336A) in complex with a synthetic CSIM tetrapeptide from the C-terminus of prelamin A Classification HYDROLASE/PEPTIDE Compound CAAX PRENYL PROTEASE 1 HOMOLOG Source null (LMNA_HUMAN) Sequence A:  GMWASLDALWEMPAEKRIFGAVLLFSWTVYLWETFLAQRQ RRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSFWS GLYSETEGTLILLFGGIPYLWRLSGRPEYEITQSLVFLLL ATLFSALAGLPWSLYNTFVIEEKHGFNQQTLGFFMKDAIK KFVVTQCILLPVSSLLLYIIKIGGDYFFIYAWLFTLVVSL VLVTIYADYIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPL TKVYVVEGSKRSSHSNAYFYGFKRIVLFDTLLEQGCKNEE VLAVLGHALGHWKLGHTVKNIIISQMNSFLCFFLFAVLIG RKELFAAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLT VLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVS DWLFSMWHYSHPPLLERLQALKTM Description (1)  CAAX PRENYL PROTEASE 1 HOMOLOG (E.C.3.4.24.84), PRELAMIN-A/C Functional site 1) chain A residue 335 type sequence H description BINDING SITE FOR RESIDUE ZN A 600 source : AC1 2) chain A residue 339 type sequence H description BINDING SITE FOR RESIDUE ZN A 600 source : AC1 3) chain A residue 415 type sequence E description BINDING SITE FOR RESIDUE ZN A 600 source : AC1 4) chain A residue 196-216 type LIPID sequence FFIYAWLFTLVVSLVLVTIYA description S-farnesyl cysteine => ECO:0000269|PubMed:8175923, ECO:0000269|PubMed:9030603 source Swiss-Prot : SWS_FT_FI2 5) chain A residue 348-368 type LIPID sequence NIIISQMNSFLCFFLFAVLIG description S-farnesyl cysteine => ECO:0000269|PubMed:8175923, ECO:0000269|PubMed:9030603 source Swiss-Prot : SWS_FT_FI2 6) chain A residue 383-405 type LIPID sequence PTLIGLLIIFQFIFSPYNEVLSF description S-farnesyl cysteine => ECO:0000269|PubMed:8175923, ECO:0000269|PubMed:9030603 source Swiss-Prot : SWS_FT_FI2 7) chain A residue 40-81 type TOPO_DOM sequence RQRRIYKTTTHVPPELGQIMDSETFEKSRLYQLDKSTFSF WS description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 8) chain A residue 145-170 type TOPO_DOM sequence NTFVIEEKHGFNQQTLGFFMKDAIKK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 9) chain A residue 217-347 type TOPO_DOM sequence DYIAPLFDKFTPLPEGKLKEEIEVMAKSIDFPLTKVYVVE GSKRSSHSNAYFYGFKRIVLFDTLLEQGCKNEEVLAVLGH ALGHWKLGHTVK description Nuclear => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 10) chain A residue 336 type ACT_SITE sequence A description ACT_SITE => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI4 11) chain A residue 339 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 12) chain A residue 415 type BINDING sequence E description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5 13) chain A residue 335 type BINDING sequence H description BINDING => ECO:0000269|PubMed:23539603 source Swiss-Prot : SWS_FT_FI5

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