eF-site ID 2yhv-A PDB Code 2yhv Chain A click to enlarge Title Structure of L1196M Mutant Anaplastic Lymphoma Kinase Classification TRANSFERASE Compound ALK TYROSINE KINASE RECEPTOR Source (ALK_HUMAN) Sequence A:  NPNYCFAGKTSSISDLKEVPRKNITLIRGLAFGEVYEGQV PLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCI GVSLQSLPRFILMELMAGGDLKSFLRETRPRPSQPSSLAM LDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPG RVAKIGDFGMARDIYRGGCAMLPVKWMPPEAFMEGIFTSK TDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMD PPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQD PDVINTALPIEY Description Functional site 1) chain A residue 1249 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 1197 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 3) chain A residue 1150 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI3 4) chain A residue 1270 type BINDING sequence D description BINDING => ECO:0000269|PubMed:20632993 source Swiss-Prot : SWS_FT_FI4 5) chain A residue 1131 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI6 6) chain A residue 1096 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:16878150, ECO:0007744|PubMed:15592455 source Swiss-Prot : SWS_FT_FI5 7) chain A residue 1122-1150 type prosite sequence LAFGEVYEGQVPLQVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGHGAFGEVYeGqvsgmpndpsplq.....VAVK source prosite : PS00107 8) chain A residue 1245-1257 type prosite sequence FIHRDIAARNCLL description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDIAARNCLL source prosite : PS00109 9) chain A residue 1278 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:15938644 source Swiss-Prot : SWS_FT_FI7

Display surface Download Links