|
|
eF-site ID
|
2yho-F |
|
PDB Code
|
2yho |
|
Chain
|
F |
|
click to enlarge
|
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Title
|
The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor |
|
Classification
|
LIGASE |
|
Compound
|
E3 UBIQUITIN-PROTEIN LIGASE MYLIP |
|
Source
|
Homo sapiens (Human) (UB2D1_HUMAN) |
|
|
Sequence
|
F: |
GAMALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIM
GPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNI
NSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDP
LVPDIAQIYKSDKEKYNRHAREWTQKYAM
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
F |
| residue |
-1 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE ZN C 1001
|
| source |
: AC3
|
|
|
2)
|
chain |
F |
| residue |
67 |
| type |
|
| sequence |
I
|
| description |
BINDING SITE FOR RESIDUE ACT F 1148
|
| source |
: BC4
|
|
|
3)
|
chain |
F |
| residue |
83 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE ACT F 1148
|
| source |
: BC4
|
|
|
4)
|
chain |
F |
| residue |
84 |
| type |
|
| sequence |
I
|
| description |
BINDING SITE FOR RESIDUE ACT F 1148
|
| source |
: BC4
|
|
|
5)
|
chain |
F |
| residue |
85 |
| type |
ACT_SITE |
| sequence |
C
|
| description |
Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|