eF-site ID 2yho-B PDB Code 2yho Chain B click to enlarge Title The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor Classification LIGASE Compound E3 UBIQUITIN-PROTEIN LIGASE MYLIP Source Homo sapiens (Human) (UB2D1_HUMAN) Sequence B:  GAMALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIM GPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNI NSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDP LVPDIAQIYKSDKEKYNRHAREWTQKYAM Description Functional site 1) chain B residue 67 type sequence I description BINDING SITE FOR RESIDUE ACT B 1148 source : BC3 2) chain B residue 84 type sequence I description BINDING SITE FOR RESIDUE ACT B 1148 source : BC3 3) chain B residue 69 type sequence F description BINDING SITE FOR RESIDUE ACT B 1149 source : BC5 4) chain B residue 70 type sequence T description BINDING SITE FOR RESIDUE ACT B 1149 source : BC5 5) chain B residue 80 type sequence S description BINDING SITE FOR RESIDUE ACT B 1149 source : BC5 6) chain B residue 82 type sequence G description BINDING SITE FOR RESIDUE ACT B 1149 source : BC5 7) chain B residue 74-89 type prosite sequence YHPNINSNGSICLDIL description UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNInsn.GsICLdiL source prosite : PS00183 8) chain B residue 85 type ACT_SITE sequence C description Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133 source Swiss-Prot : SWS_FT_FI1

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