eF-site ID 2yfe-AB PDB Code 2yfe Chain A, B click to enlarge Title Ligand binding domain of human PPAR gamma in complex with amorfrutin 1 Classification RECEPTOR Compound PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA Source Homo sapiens (Human) (PPARG_HUMAN) Sequence A:  DQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKT TDKSPFVIYDMNSLMMGEDKISKEVAIRIFQGCQFRSVEA VQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAV KFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDN LLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL LQVIKKTETDMSLHPLLQEIYKDL B:  PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKS PFVIYDMNSLMMGEDKIKFKHITPSKEVAIRIFQGCQFRS VEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTM LASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFE FAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEH VQLLQVIKKTETDMLHPLLQEIYK Description Functional site 1) chain A residue 280 type sequence R description BINDING SITE FOR RESIDUE YFE A 999 source : AC1 2) chain A residue 281 type sequence I description BINDING SITE FOR RESIDUE YFE A 999 source : AC1 3) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE YFE A 999 source : AC1 4) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE YFE A 999 source : AC1 5) chain A residue 330 type sequence L description BINDING SITE FOR RESIDUE YFE A 999 source : AC1 6) chain A residue 341 type sequence I description BINDING SITE FOR RESIDUE YFE A 999 source : AC1 7) chain A residue 342 type sequence S description BINDING SITE FOR RESIDUE YFE A 999 source : AC1 8) chain A residue 348 type sequence M description BINDING SITE FOR RESIDUE YFE A 999 source : AC1 9) chain B residue 226 type sequence F description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 10) chain B residue 255 type sequence L description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 11) chain B residue 259 type sequence E description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 12) chain B residue 264 type sequence F description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 13) chain B residue 266 type sequence H description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 14) chain B residue 280 type sequence R description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 15) chain B residue 281 type sequence I description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 16) chain B residue 285 type sequence C description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 17) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 18) chain B residue 289 type sequence S description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 19) chain B residue 292 type sequence A description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 20) chain B residue 329 type sequence M description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 21) chain B residue 330 type sequence L description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 22) chain B residue 333 type sequence L description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 23) chain B residue 340 type sequence L description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 24) chain B residue 341 type sequence I description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 25) chain B residue 342 type sequence S description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 26) chain B residue 348 type sequence M description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 27) chain B residue 363 type sequence F description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 28) chain B residue 364 type sequence M description BINDING SITE FOR RESIDUE YFE B 999 source : AC2 29) chain A residue 252 type CROSSLNK sequence M description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 30) chain B residue 252 type CROSSLNK sequence M description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 314 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 32) chain A residue 351 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 33) chain B residue 351 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 34) chain B residue 314 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1

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