eF-site ID 2ydv-A PDB Code 2ydv Chain A click to enlarge Title Thermostabilised HUMAN A2a Receptor with NECA bound Classification RECEPTOR Compound ADENOSINE RECEPTOR A2A Source (AA2AR_HUMAN) Sequence A:  IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTN YFVVSAAAADILVGVLAIPFAIAISTGFCAACHGCLFIAC FVLVLTASSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAK GIIAICWVLSFAIGLTPMLGWNNCGQPKEGKAHSQGCGEG QVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFL AARRQLKQMESQSTLQKEVHAAKSLAIIVGLFALCWLPLH IINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAY RIREFRQTFRKIIRSHVLRQQEPFKAAAAENLYFQ Description Functional site 1) chain A residue 67-77 type TOPO_DOM sequence STGFCAACHGC description Extracellular => ECO:0000269|PubMed:18832607 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 144-173 type TOPO_DOM sequence NNCGQPKEGKAHSQGCGEGQVACLFEDVVP description Extracellular => ECO:0000269|PubMed:18832607 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 259-266 type TOPO_DOM sequence CPDCSHAP description Extracellular => ECO:0000269|PubMed:18832607 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 33-42 type TOPO_DOM sequence LNSNLQNVTN description Cytoplasmic => ECO:0000269|PubMed:18832607 source Swiss-Prot : SWS_FT_FI3 5) chain A residue 101-120 type TOPO_DOM sequence DRYIAIRIPLRYNGLVTGTR description Cytoplasmic => ECO:0000269|PubMed:18832607 source Swiss-Prot : SWS_FT_FI3 6) chain A residue 199-234 type TOPO_DOM sequence RIFLAARRQLKQMESQSTLQKEVHAAKS description Cytoplasmic => ECO:0000269|PubMed:18832607 source Swiss-Prot : SWS_FT_FI3 7) chain A residue 169 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO source Swiss-Prot : SWS_FT_FI10 8) chain A residue 253 type BINDING sequence N description BINDING => ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO source Swiss-Prot : SWS_FT_FI10 9) chain A residue 277 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO source Swiss-Prot : SWS_FT_FI10 10) chain A residue 278 type BINDING sequence H description BINDING => ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO source Swiss-Prot : SWS_FT_FI10 11) chain A residue 90-106 type prosite sequence SSIFSLLAIAIDRYIAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSIfSLLAIAIDRYIaI source prosite : PS00237 12) chain A residue 8-32 type TRANSMEM sequence VYITVELAIAVLAILGNVLVCWAVW description Helical; Name=1 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 43-66 type TRANSMEM sequence YFVVSAAAADILVGVLAIPFAIAI description Helical; Name=2 source Swiss-Prot : SWS_FT_FI4 14) chain A residue 78-100 type TRANSMEM sequence LFIACFVLVLTASSIFSLLAIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 15) chain A residue 121-143 type TRANSMEM sequence AKGIIAICWVLSFAIGLTPMLGW description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 16) chain A residue 174-198 type TRANSMEM sequence MNYMVYFNFFACVLVPLLLMLGVYL description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 17) chain A residue 235-258 type TRANSMEM sequence LAIIVGLFALCWLPLHIINCFTFF description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 18) chain A residue 267-290 type TRANSMEM sequence LWLMYLAIVLSHTNSVVNPFIYAY description Helical; Name=7 source Swiss-Prot : SWS_FT_FI9 19) chain A residue 154 type CARBOHYD sequence A description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI11

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