eF-site ID 2ycz-AB PDB Code 2ycz Chain A, B click to enlarge Title TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST IODOCYANOPINDOLOL Classification RECEPTOR Compound BETA-1 ADRENERGIC RECEPTOR Source (ADRB1_MELGA) Sequence A:  QWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNL FITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWT SLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARA KVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGC CDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQI RKIDRASKRKRVMLMREHKALKTLGIIMGVFTLCWLPFFL VNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPD FRKAFKRLLAF B:  QWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNL FITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWT SLDVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARA KVIICTVWAISALVSFLPIMMHWWRDEDPQALKCYQDPGC CDFVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQI RKIDRASKRKRVMLMREHKALKTLGIIMGVFTLCWLPFFL VNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPD FRKAFKRLLAF Description Functional site 1) chain A residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 2) chain A residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 3) chain A residue 232-315 type TOPO_DOM sequence REAKEQIRKIDRASKRKRVMLMREHKALKTLGIIMGVFTL CWLPFFLVNIVNVF description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 4) chain B residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 5) chain B residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 6) chain B residue 232-315 type TOPO_DOM sequence REAKEQIRKIDRASKRKRVMLMREHKALKTLGIIMGVFTL CWLPFFLVNIVNVF description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 7) chain A residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 8) chain A residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 9) chain B residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 10) chain B residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 11) chain B residue 316-320 type TOPO_DOM sequence NRDLV description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 12) chain A residue 346-350 type TOPO_DOM sequence SPDFR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 13) chain A residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 14) chain A residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 15) chain B residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 16) chain B residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 17) chain B residue 329 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 18) chain A residue 359 type BINDING sequence F description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 19) chain B residue 358 type LIPID sequence A description S-palmitoyl cysteine => ECO:0000250 source Swiss-Prot : SWS_FT_FI11 20) chain A residue 127-143 type prosite sequence ASIETLCVIAIDRYLAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAIDRYLaI source prosite : PS00237 21) chain A residue 39-67 type TRANSMEM sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 39-67 type TRANSMEM sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 24) chain B residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 25) chain A residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASIETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 26) chain B residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASIETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 27) chain A residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 28) chain B residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 29) chain A residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 30) chain B residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 31) chain B residue 286-315 type TRANSMEM sequence HKALKTLGIIMGVFTLCWLPFFLVNIVNVF description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 32) chain A residue 316-345 type TRANSMEM sequence NRDLVPDWLFVAFNWLGYANSAMNPIIYCR description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 33) chain B residue 321-343 type TRANSMEM sequence PDWLFVAFNWLGYANSAMNPIIY description Helical; Name=7 source Swiss-Prot : SWS_FT_FI9

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