eF-site ID 2yc0-A PDB Code 2yc0 Chain A click to enlarge Title FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH R-2-HYDROXYGLUTARATE Classification OXIDOREDUCTASE Compound HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR Source (HIF1N_HUMAN) Sequence A:  MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTR PIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEY LQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNR EEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVM DFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHY DEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQS QVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHH IESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMR NIEKMLGEALGNPQEVGPLLNTMIKGRYN Description Functional site 1) chain A residue 199 type sequence H description BINDING SITE FOR RESIDUE FE2 A 501 source : AC1 2) chain A residue 201 type sequence D description BINDING SITE FOR RESIDUE FE2 A 501 source : AC1 3) chain A residue 279 type sequence H description BINDING SITE FOR RESIDUE FE2 A 501 source : AC1 4) chain A residue 145 type sequence Y description BINDING SITE FOR RESIDUE 2HG A 601 source : AC2 5) chain A residue 196 type sequence T description BINDING SITE FOR RESIDUE 2HG A 601 source : AC2 6) chain A residue 199 type sequence H description BINDING SITE FOR RESIDUE 2HG A 601 source : AC2 7) chain A residue 201 type sequence D description BINDING SITE FOR RESIDUE 2HG A 601 source : AC2 8) chain A residue 205 type sequence N description BINDING SITE FOR RESIDUE 2HG A 601 source : AC2 9) chain A residue 207 type sequence F description BINDING SITE FOR RESIDUE 2HG A 601 source : AC2 10) chain A residue 214 type sequence K description BINDING SITE FOR RESIDUE 2HG A 601 source : AC2 11) chain A residue 279 type sequence H description BINDING SITE FOR RESIDUE 2HG A 601 source : AC2 12) chain A residue 281 type sequence I description BINDING SITE FOR RESIDUE 2HG A 601 source : AC2 13) chain A residue 294 type sequence N description BINDING SITE FOR RESIDUE 2HG A 601 source : AC2 14) chain A residue 296 type sequence W description BINDING SITE FOR RESIDUE 2HG A 601 source : AC2 15) chain A residue 99 type sequence K description BINDING SITE FOR RESIDUE GOL A 602 source : AC3 16) chain A residue 101 type sequence L description BINDING SITE FOR RESIDUE GOL A 602 source : AC3 17) chain A residue 230 type sequence Y description BINDING SITE FOR RESIDUE GOL A 602 source : AC3 18) chain A residue 240 type sequence S description BINDING SITE FOR RESIDUE GOL A 602 source : AC3 19) chain A residue 241 type sequence Q description BINDING SITE FOR RESIDUE GOL A 602 source : AC3 20) chain A residue 243 type sequence D description BINDING SITE FOR RESIDUE GOL A 602 source : AC3 21) chain A residue 222 type sequence D description BINDING SITE FOR RESIDUE GOL A 603 source : AC4 22) chain A residue 315 type sequence K description BINDING SITE FOR RESIDUE GOL A 603 source : AC4 23) chain A residue 319 type sequence M description BINDING SITE FOR RESIDUE GOL A 603 source : AC4 24) chain A residue 102 type sequence Y description BINDING SITE FOR RESIDUE GOL A 604 source : AC5 25) chain A residue 147 type sequence Q description BINDING SITE FOR RESIDUE GOL A 604 source : AC5 26) chain A residue 196 type sequence T description BINDING SITE FOR RESIDUE GOL A 604 source : AC5 27) chain A residue 199 type sequence H description BINDING SITE FOR RESIDUE GOL A 604 source : AC5 28) chain A residue 201 type sequence D description BINDING SITE FOR RESIDUE GOL A 604 source : AC5 29) chain A residue 296 type sequence W description BINDING SITE FOR RESIDUE GOL A 604 source : AC5 30) chain A residue 222 type sequence D description BINDING SITE FOR RESIDUE SO4 A 901 source : AC6 31) chain A residue 311 type sequence K description BINDING SITE FOR RESIDUE SO4 A 901 source : AC6 32) chain A residue 312 type sequence A description BINDING SITE FOR RESIDUE SO4 A 901 source : AC6 33) chain A residue 138 type sequence R description BINDING SITE FOR RESIDUE SO4 A 902 source : AC7 34) chain A residue 140 type sequence G description BINDING SITE FOR RESIDUE SO4 A 902 source : AC7 35) chain A residue 141 type sequence E description BINDING SITE FOR RESIDUE SO4 A 902 source : AC7 36) chain A residue 142 type sequence E description BINDING SITE FOR RESIDUE SO4 A 902 source : AC7 37) chain A residue 120 type sequence R description BINDING SITE FOR RESIDUE SO4 A 904 source : AC8 38) chain A residue 143 type sequence R description BINDING SITE FOR RESIDUE SO4 A 905 source : AC9 39) chain A residue 192 type sequence E description BINDING SITE FOR RESIDUE SO4 A 905 source : AC9 40) chain A residue 193 type sequence G description BINDING SITE FOR RESIDUE SO4 A 905 source : AC9 41) chain A residue 285 type sequence L description BINDING SITE FOR RESIDUE SO4 A 905 source : AC9 42) chain A residue 286 type sequence N description BINDING SITE FOR RESIDUE SO4 A 905 source : AC9 43) chain A residue 145 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 196 type BINDING sequence T description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 45) chain A residue 205 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 214 type BINDING sequence K description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 294 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:21251231 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 152 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 49) chain A residue 181 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 50) chain A residue 238 type BINDING sequence R description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 51) chain A residue 300 type BINDING sequence A description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 52) chain A residue 321 type BINDING sequence N description BINDING => ECO:0000269|PubMed:21177872 source Swiss-Prot : SWS_FT_FI2 53) chain A residue 199 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 54) chain A residue 201 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 55) chain A residue 279 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12432100, ECO:0000269|PubMed:12446723, ECO:0000269|PubMed:15913349, ECO:0000269|PubMed:17135241, ECO:0000269|PubMed:20396966, ECO:0000269|PubMed:20822901, ECO:0000269|PubMed:21251231, ECO:0000269|PubMed:21460794 source Swiss-Prot : SWS_FT_FI3 56) chain A residue 340 type SITE sequence L description Important for dimer formation source Swiss-Prot : SWS_FT_FI4 57) chain A residue 2 type MOD_RES sequence A description N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 source Swiss-Prot : SWS_FT_FI5

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