eF-site ID 2ya3-E PDB Code 2ya3 Chain E click to enlarge Title STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEX WITH COUMARIN ADP Classification TRANSFERASE Compound 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 Source null (AAKG1_RAT) Sequence E:  SSVYTTFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALV TNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQ IYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSL IRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPK PEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRV SALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKA LQHRSHYFEGVLKCYLHETLEAIINRLVEAEVHRLVVVDE HDVVKGIVSLSDILQALVLT Description Functional site 1) chain E residue 84 type sequence M description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 2) chain E residue 86 type sequence T description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 3) chain E residue 88 type sequence T description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 4) chain E residue 89 type sequence D description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 5) chain E residue 92 type sequence N description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 6) chain E residue 96 type sequence R description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 7) chain E residue 120 type sequence Y description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 8) chain E residue 126 type sequence K description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 9) chain E residue 128 type sequence L description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 10) chain E residue 129 type sequence V description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 11) chain E residue 149 type sequence I description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 12) chain E residue 150 type sequence H description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 13) chain E residue 151 type sequence R description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 14) chain E residue 153 type sequence P description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 15) chain E residue 242 type sequence K description BINDING SITE FOR RESIDUE J7V E 1325 source : AC1 16) chain E residue 69 type sequence R description BINDING SITE FOR RESIDUE J7V E 1326 source : AC2 17) chain E residue 169 type sequence K description BINDING SITE FOR RESIDUE J7V E 1326 source : AC2 18) chain E residue 225 type sequence S description BINDING SITE FOR RESIDUE J7V E 1326 source : AC2 19) chain E residue 241 type sequence S description BINDING SITE FOR RESIDUE J7V E 1326 source : AC2 20) chain E residue 242 type sequence K description BINDING SITE FOR RESIDUE J7V E 1326 source : AC2 21) chain E residue 243 type sequence F description BINDING SITE FOR RESIDUE J7V E 1326 source : AC2 22) chain E residue 274 type sequence G description BINDING SITE FOR RESIDUE J7V E 1326 source : AC2 23) chain E residue 275 type sequence V description BINDING SITE FOR RESIDUE J7V E 1326 source : AC2 24) chain E residue 276 type sequence L description BINDING SITE FOR RESIDUE J7V E 1326 source : AC2 25) chain E residue 296 type sequence V description BINDING SITE FOR RESIDUE J7V E 1326 source : AC2 26) chain E residue 297 type sequence H description BINDING SITE FOR RESIDUE J7V E 1326 source : AC2 27) chain E residue 298 type sequence R description BINDING SITE FOR RESIDUE J7V E 1326 source : AC2 28) chain E residue 150 type sequence H description BINDING SITE FOR RESIDUE AMP E 1327 source : AC3 29) chain E residue 199 type sequence T description BINDING SITE FOR RESIDUE AMP E 1327 source : AC3 30) chain E residue 203 type sequence I description BINDING SITE FOR RESIDUE AMP E 1327 source : AC3 31) chain E residue 204 type sequence A description BINDING SITE FOR RESIDUE AMP E 1327 source : AC3 32) chain E residue 224 type sequence V description BINDING SITE FOR RESIDUE AMP E 1327 source : AC3 33) chain E residue 225 type sequence S description BINDING SITE FOR RESIDUE AMP E 1327 source : AC3 34) chain E residue 226 type sequence A description BINDING SITE FOR RESIDUE AMP E 1327 source : AC3 35) chain E residue 297 type sequence H description BINDING SITE FOR RESIDUE AMP E 1327 source : AC3 36) chain E residue 311 type sequence I description BINDING SITE FOR RESIDUE AMP E 1327 source : AC3 37) chain E residue 313 type sequence S description BINDING SITE FOR RESIDUE AMP E 1327 source : AC3 38) chain E residue 315 type sequence S description BINDING SITE FOR RESIDUE AMP E 1327 source : AC3 39) chain E residue 316 type sequence D description BINDING SITE FOR RESIDUE AMP E 1327 source : AC3 40) chain E residue 69 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17851531, ECO:0007744|PDB:2V92 source Swiss-Prot : SWS_FT_FI1 41) chain E residue 84 type BINDING sequence M description BINDING => ECO:0000269|PubMed:17851531, ECO:0007744|PDB:2V92 source Swiss-Prot : SWS_FT_FI1 42) chain E residue 129 type BINDING sequence V description BINDING => ECO:0000269|PubMed:17851531, ECO:0007744|PDB:2V92 source Swiss-Prot : SWS_FT_FI1 43) chain E residue 151 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17851531, ECO:0007744|PDB:2V92 source Swiss-Prot : SWS_FT_FI1 44) chain E residue 169 type BINDING sequence K description BINDING => ECO:0000269|PubMed:17851531, ECO:0007744|PDB:2V92 source Swiss-Prot : SWS_FT_FI1 45) chain E residue 241 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17851531, ECO:0007744|PDB:2V92 source Swiss-Prot : SWS_FT_FI1 46) chain E residue 268 type BINDING sequence R description BINDING => ECO:0000269|PubMed:17851531, ECO:0007744|PDB:2V92 source Swiss-Prot : SWS_FT_FI1 47) chain E residue 276 type BINDING sequence L description BINDING => ECO:0000269|PubMed:17851531, ECO:0007744|PDB:2V92 source Swiss-Prot : SWS_FT_FI1 48) chain E residue 150 type BINDING sequence H description BINDING => ECO:0000269|PubMed:17851531, ECO:0000269|PubMed:21399626, ECO:0007744|PDB:2V8Q, ECO:0007744|PDB:2Y8L source Swiss-Prot : SWS_FT_FI2 49) chain E residue 199 type BINDING sequence T description BINDING => ECO:0000269|PubMed:17851531, ECO:0000269|PubMed:21399626, ECO:0007744|PDB:2V8Q, ECO:0007744|PDB:2Y8L source Swiss-Prot : SWS_FT_FI2 50) chain E residue 204 type BINDING sequence A description BINDING => ECO:0000269|PubMed:17851531, ECO:0000269|PubMed:21399626, ECO:0007744|PDB:2V8Q, ECO:0007744|PDB:2Y8L source Swiss-Prot : SWS_FT_FI2 51) chain E residue 225 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17851531, ECO:0000269|PubMed:21399626, ECO:0007744|PDB:2V8Q, ECO:0007744|PDB:2Y8L source Swiss-Prot : SWS_FT_FI2 52) chain E residue 297 type BINDING sequence H description BINDING => ECO:0000269|PubMed:17851531, ECO:0000269|PubMed:21399626, ECO:0007744|PDB:2V8Q, ECO:0007744|PDB:2Y8L source Swiss-Prot : SWS_FT_FI2 53) chain E residue 313 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17851531, ECO:0000269|PubMed:21399626, ECO:0007744|PDB:2V8Q, ECO:0007744|PDB:2Y8L source Swiss-Prot : SWS_FT_FI2 54) chain E residue 260 type MOD_RES sequence S description Phosphoserine; by ULK1 => ECO:0000305|PubMed:21460634 source Swiss-Prot : SWS_FT_FI3 55) chain E residue 262 type MOD_RES sequence T description Phosphothreonine; by ULK1 => ECO:0000305|PubMed:21460634 source Swiss-Prot : SWS_FT_FI4 56) chain E residue 269 type MOD_RES sequence S description Phosphoserine; by ULK1 => ECO:0000269|PubMed:21460634 source Swiss-Prot : SWS_FT_FI5

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