eF-site ID 2y82-A PDB Code 2y82 Chain A click to enlarge Title Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs Classification BLOOD CLOTTING Compound ACTIVATED FACTOR XA HEAVY CHAIN Source ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS; Sequence A:  IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTA AHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRF TKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLM TQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSS SFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVT GIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTR Description (1)  ACTIVATED FACTOR XA HEAVY CHAIN (E.C.3.4.21.6), FACTOR X LIGHT CHAIN (E.C.3.4.21.6) Functional site 1) chain A residue 97 type sequence E description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 2) chain A residue 98 type sequence T description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 3) chain A residue 99 type sequence Y description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 4) chain A residue 174 type sequence F description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 5) chain A residue 189 type sequence D description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 6) chain A residue 190 type sequence A description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 7) chain A residue 192 type sequence Q description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 8) chain A residue 195 type sequence S description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 9) chain A residue 213 type sequence V description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 10) chain A residue 215 type sequence W description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 11) chain A residue 216 type sequence G description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 12) chain A residue 219 type sequence G description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 13) chain A residue 220 type sequence C description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 14) chain A residue 226 type sequence G description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 15) chain A residue 227 type sequence I description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 16) chain A residue 228 type sequence Y description BINDING SITE FOR RESIDUE 930 A 1245 source : AC1 17) chain A residue 70 type sequence D description BINDING SITE FOR RESIDUE CA A 1246 source : AC2 18) chain A residue 72 type sequence N description BINDING SITE FOR RESIDUE CA A 1246 source : AC2 19) chain A residue 75 type sequence Q description BINDING SITE FOR RESIDUE CA A 1246 source : AC2 20) chain A residue 77 type sequence E description BINDING SITE FOR RESIDUE CA A 1246 source : AC2 21) chain A residue 80 type sequence E description BINDING SITE FOR RESIDUE CA A 1246 source : AC2 22) chain A residue 185 type sequence Y description BINDING SITE FOR RESIDUE MG A 1247 source : AC3 23) chain A residue 185 type sequence Y description BINDING SITE FOR RESIDUE MG A 1247 source : AC3 24) chain A residue 222 type sequence R description BINDING SITE FOR RESIDUE MG A 1247 source : AC3 25) chain A residue 224 type sequence K description BINDING SITE FOR RESIDUE MG A 1247 source : AC3 26) chain A residue 53-58 type prosite sequence LTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC source prosite : PS00134 27) chain A residue 189-200 type prosite sequence DACQGDSGGPHV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAcqGDSGGPHV source prosite : PS00135

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