eF-site ID 2y56-ABCDE PDB Code 2y56 Chain A, B, C, D, E click to enlarge Title Fragment growing induces conformational changes in acetylcholine- binding protein: A structural and thermodynamic analysis - (Compound 3) Classification RECEPTOR Compound SOLUBLE ACETYLCHOLINE RECEPTOR Source (Q8WSF8_APLCA) Sequence A:  QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVK VDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSA ADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQR LSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQ VDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVV KFRER B:  QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVK VDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSA ADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQR LSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQ VDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVV KFRER C:  QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVK VDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSA ADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQR LSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQ VDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVV KFRER D:  QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVK VDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSA ADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQR LSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQ VDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVV KFRER E:  QANLMRLKSDLFNRSPMYPGPTKDDPLTVTLGFTLQDIVK VDSSTNEVDLVYYEQQRWKLNSLMWDPNEYGNITDFRTSA ADIWTPDITAYSSTRPVQVLSPQIAVVTHDGSVMFIPAQR LSFMCDPTGVDSEEGVTCAVKFGSWVYSGFEIDLKTDTDQ VDLSSYYASSKYEILSATQTRQVQHYSCCPEPYIDVNLVV KFRER Description Functional site 1) chain A residue 89 type sequence T description BINDING SITE FOR RESIDUE V11 A 301 source : AC1 2) chain A residue 91 type sequence Y description BINDING SITE FOR RESIDUE V11 A 301 source : AC1 3) chain A residue 141 type sequence K description BINDING SITE FOR RESIDUE V11 A 301 source : AC1 4) chain A residue 143 type sequence G description BINDING SITE FOR RESIDUE V11 A 301 source : AC1 5) chain A residue 144 type sequence S description BINDING SITE FOR RESIDUE V11 A 301 source : AC1 6) chain A residue 145 type sequence W description BINDING SITE FOR RESIDUE V11 A 301 source : AC1 7) chain A residue 186 type sequence Y description BINDING SITE FOR RESIDUE V11 A 301 source : AC1 8) chain A residue 188 type sequence C description BINDING SITE FOR RESIDUE V11 A 301 source : AC1 9) chain A residue 189 type sequence C description BINDING SITE FOR RESIDUE V11 A 301 source : AC1 10) chain A residue 193 type sequence Y description BINDING SITE FOR RESIDUE V11 A 301 source : AC1 11) chain B residue 53 type sequence Y description BINDING SITE FOR RESIDUE V11 A 301 source : AC1 12) chain B residue 55 type sequence Q description BINDING SITE FOR RESIDUE V11 A 301 source : AC1 13) chain B residue 116 type sequence I description BINDING SITE FOR RESIDUE V11 A 301 source : AC1 14) chain A residue 40 type sequence K description BINDING SITE FOR RESIDUE CL A 501 source : AC2 15) chain E residue 95 type sequence R description BINDING SITE FOR RESIDUE CL A 501 source : AC2 16) chain B residue 116 type sequence I description BINDING SITE FOR RESIDUE CL A 502 source : AC3 17) chain A residue 141 type sequence K description BINDING SITE FOR RESIDUE SO4 A 601 source : AC4 18) chain A residue 182 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 601 source : AC4 19) chain A residue 184 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 601 source : AC4 20) chain A residue 1 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 602 source : AC5 21) chain A residue 2 type sequence A description BINDING SITE FOR RESIDUE SO4 A 602 source : AC5 22) chain A residue 3 type sequence N description BINDING SITE FOR RESIDUE SO4 A 602 source : AC5 23) chain A residue 158 type sequence T description BINDING SITE FOR RESIDUE GOL A 701 source : AC6 24) chain A residue 159 type sequence D description BINDING SITE FOR RESIDUE GOL A 701 source : AC6 25) chain A residue 205 type sequence R description BINDING SITE FOR RESIDUE GOL A 702 source : AC7 26) chain B residue 89 type sequence T description BINDING SITE FOR RESIDUE V11 B 301 source : AC8 27) chain B residue 91 type sequence Y description BINDING SITE FOR RESIDUE V11 B 301 source : AC8 28) chain B residue 143 type sequence G description BINDING SITE FOR RESIDUE V11 B 301 source : AC8 29) chain B residue 144 type sequence S description BINDING SITE FOR RESIDUE V11 B 301 source : AC8 30) chain B residue 145 type sequence W description BINDING SITE FOR RESIDUE V11 B 301 source : AC8 31) chain B residue 186 type sequence Y description BINDING SITE FOR RESIDUE V11 B 301 source : AC8 32) chain B residue 188 type sequence C description BINDING SITE FOR RESIDUE V11 B 301 source : AC8 33) chain B residue 189 type sequence C description BINDING SITE FOR RESIDUE V11 B 301 source : AC8 34) chain B residue 193 type sequence Y description BINDING SITE FOR RESIDUE V11 B 301 source : AC8 35) chain C residue 55 type sequence Q description BINDING SITE FOR RESIDUE V11 B 301 source : AC8 36) chain C residue 116 type sequence I description BINDING SITE FOR RESIDUE V11 B 301 source : AC8 37) chain B residue 40 type sequence K description BINDING SITE FOR RESIDUE CL B 501 source : AC9 38) chain C residue 116 type sequence I description BINDING SITE FOR RESIDUE CL B 502 source : BC1 39) chain B residue 147 type sequence Y description BINDING SITE FOR RESIDUE CL B 503 source : BC2 40) chain A residue 126 type sequence D description BINDING SITE FOR RESIDUE SO4 B 601 source : BC3 41) chain B residue 167 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 601 source : BC3 42) chain B residue 169 type sequence S description BINDING SITE FOR RESIDUE SO4 B 601 source : BC3 43) chain B residue 1 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 602 source : BC4 44) chain B residue 2 type sequence A description BINDING SITE FOR RESIDUE SO4 B 602 source : BC4 45) chain B residue 3 type sequence N description BINDING SITE FOR RESIDUE SO4 B 602 source : BC4 46) chain B residue 186 type sequence Y description BINDING SITE FOR RESIDUE GOL B 701 source : BC5 47) chain B residue 187 type sequence S description BINDING SITE FOR RESIDUE GOL B 701 source : BC5 48) chain B residue 188 type sequence C description BINDING SITE FOR RESIDUE GOL B 701 source : BC5 49) chain C residue 162 type sequence D description BINDING SITE FOR RESIDUE GOL B 701 source : BC5 50) chain C residue 164 type sequence S description BINDING SITE FOR RESIDUE GOL B 701 source : BC5 51) chain C residue 165 type sequence S description BINDING SITE FOR RESIDUE GOL B 701 source : BC5 52) chain C residue 89 type sequence T description BINDING SITE FOR RESIDUE V11 C 301 source : BC6 53) chain C residue 91 type sequence Y description BINDING SITE FOR RESIDUE V11 C 301 source : BC6 54) chain C residue 141 type sequence K description BINDING SITE FOR RESIDUE V11 C 301 source : BC6 55) chain C residue 143 type sequence G description BINDING SITE FOR RESIDUE V11 C 301 source : BC6 56) chain C residue 144 type sequence S description BINDING SITE FOR RESIDUE V11 C 301 source : BC6 57) chain C residue 145 type sequence W description BINDING SITE FOR RESIDUE V11 C 301 source : BC6 58) chain C residue 186 type sequence Y description BINDING SITE FOR RESIDUE V11 C 301 source : BC6 59) chain C residue 188 type sequence C description BINDING SITE FOR RESIDUE V11 C 301 source : BC6 60) chain C residue 189 type sequence C description BINDING SITE FOR RESIDUE V11 C 301 source : BC6 61) chain C residue 193 type sequence Y description BINDING SITE FOR RESIDUE V11 C 301 source : BC6 62) chain D residue 116 type sequence I description BINDING SITE FOR RESIDUE V11 C 301 source : BC6 63) chain B residue 95 type sequence R description BINDING SITE FOR RESIDUE CL C 501 source : BC7 64) chain C residue 40 type sequence K description BINDING SITE FOR RESIDUE CL C 501 source : BC7 65) chain D residue 116 type sequence I description BINDING SITE FOR RESIDUE CL C 502 source : BC8 66) chain C residue 1 type sequence Q description BINDING SITE FOR RESIDUE SO4 C 601 source : BC9 67) chain C residue 2 type sequence A description BINDING SITE FOR RESIDUE SO4 C 601 source : BC9 68) chain C residue 3 type sequence N description BINDING SITE FOR RESIDUE SO4 C 601 source : BC9 69) chain C residue 25 type sequence D description BINDING SITE FOR RESIDUE SO4 C 602 source : CC1 70) chain C residue 59 type sequence K description BINDING SITE FOR RESIDUE SO4 C 602 source : CC1 71) chain C residue 60 type sequence L description BINDING SITE FOR RESIDUE SO4 C 602 source : CC1 72) chain C residue 61 type sequence N description BINDING SITE FOR RESIDUE SO4 C 602 source : CC1 73) chain C residue 186 type sequence Y description BINDING SITE FOR RESIDUE GOL C 701 source : CC2 74) chain C residue 187 type sequence S description BINDING SITE FOR RESIDUE GOL C 701 source : CC2 75) chain C residue 188 type sequence C description BINDING SITE FOR RESIDUE GOL C 701 source : CC2 76) chain D residue 53 type sequence Y description BINDING SITE FOR RESIDUE GOL C 701 source : CC2 77) chain D residue 162 type sequence D description BINDING SITE FOR RESIDUE GOL C 701 source : CC2 78) chain D residue 164 type sequence S description BINDING SITE FOR RESIDUE GOL C 701 source : CC2 79) chain D residue 165 type sequence S description BINDING SITE FOR RESIDUE GOL C 701 source : CC2 80) chain C residue 93 type sequence S description BINDING SITE FOR RESIDUE GOL C 702 source : CC3 81) chain C residue 95 type sequence R description BINDING SITE FOR RESIDUE GOL C 702 source : CC3 82) chain C residue 96 type sequence P description BINDING SITE FOR RESIDUE GOL C 702 source : CC3 83) chain C residue 97 type sequence V description BINDING SITE FOR RESIDUE GOL C 702 source : CC3 84) chain D residue 100 type sequence L description BINDING SITE FOR RESIDUE GOL C 702 source : CC3 85) chain D residue 89 type sequence T description BINDING SITE FOR RESIDUE V11 D 301 source : CC4 86) chain D residue 91 type sequence Y description BINDING SITE FOR RESIDUE V11 D 301 source : CC4 87) chain D residue 143 type sequence G description BINDING SITE FOR RESIDUE V11 D 301 source : CC4 88) chain D residue 144 type sequence S description BINDING SITE FOR RESIDUE V11 D 301 source : CC4 89) chain D residue 145 type sequence W description BINDING SITE FOR RESIDUE V11 D 301 source : CC4 90) chain D residue 186 type sequence Y description BINDING SITE FOR RESIDUE V11 D 301 source : CC4 91) chain D residue 188 type sequence C description BINDING SITE FOR RESIDUE V11 D 301 source : CC4 92) chain D residue 189 type sequence C description BINDING SITE FOR RESIDUE V11 D 301 source : CC4 93) chain D residue 193 type sequence Y description BINDING SITE FOR RESIDUE V11 D 301 source : CC4 94) chain E residue 55 type sequence Q description BINDING SITE FOR RESIDUE V11 D 301 source : CC4 95) chain E residue 116 type sequence I description BINDING SITE FOR RESIDUE V11 D 301 source : CC4 96) chain C residue 95 type sequence R description BINDING SITE FOR RESIDUE CL D 501 source : CC5 97) chain D residue 40 type sequence K description BINDING SITE FOR RESIDUE CL D 501 source : CC5 98) chain D residue 165 type sequence S description BINDING SITE FOR RESIDUE CL D 502 source : CC6 99) chain E residue 116 type sequence I description BINDING SITE FOR RESIDUE CL D 503 source : CC7 100) chain B residue 185 type sequence H description BINDING SITE FOR RESIDUE SO4 D 601 source : CC8 101) chain C residue 126 type sequence D description BINDING SITE FOR RESIDUE SO4 D 601 source : CC8 102) chain D residue 167 type sequence Y description BINDING SITE FOR RESIDUE SO4 D 601 source : CC8 103) chain D residue 169 type sequence S description BINDING SITE FOR RESIDUE SO4 D 601 source : CC8 104) chain D residue 141 type sequence K description BINDING SITE FOR RESIDUE SO4 D 602 source : CC9 105) chain D residue 182 type sequence Q description BINDING SITE FOR RESIDUE SO4 D 602 source : CC9 106) chain D residue 197 type sequence N description BINDING SITE FOR RESIDUE SO4 D 602 source : CC9 107) chain D residue 1 type sequence Q description BINDING SITE FOR RESIDUE SO4 D 603 source : DC1 108) chain D residue 2 type sequence A description BINDING SITE FOR RESIDUE SO4 D 603 source : DC1 109) chain D residue 3 type sequence N description BINDING SITE FOR RESIDUE SO4 D 603 source : DC1 110) chain D residue 157 type sequence D description BINDING SITE FOR RESIDUE GOL D 701 source : DC2 111) chain D residue 158 type sequence T description BINDING SITE FOR RESIDUE GOL D 701 source : DC2 112) chain D residue 159 type sequence D description BINDING SITE FOR RESIDUE GOL D 701 source : DC2 113) chain D residue 17 type sequence M description BINDING SITE FOR RESIDUE GOL D 702 source : DC3 114) chain D residue 83 type sequence I description BINDING SITE FOR RESIDUE GOL D 702 source : DC3 115) chain D residue 84 type sequence W description BINDING SITE FOR RESIDUE GOL D 702 source : DC3 116) chain D residue 85 type sequence T description BINDING SITE FOR RESIDUE GOL D 702 source : DC3 117) chain D residue 79 type sequence S description BINDING SITE FOR RESIDUE GOL D 703 source : DC4 118) chain D residue 102 type sequence P description BINDING SITE FOR RESIDUE GOL D 703 source : DC4 119) chain D residue 103 type sequence Q description BINDING SITE FOR RESIDUE GOL D 703 source : DC4 120) chain A residue 116 type sequence I description BINDING SITE FOR RESIDUE V11 E 301 source : DC5 121) chain E residue 89 type sequence T description BINDING SITE FOR RESIDUE V11 E 301 source : DC5 122) chain E residue 91 type sequence Y description BINDING SITE FOR RESIDUE V11 E 301 source : DC5 123) chain E residue 141 type sequence K description BINDING SITE FOR RESIDUE V11 E 301 source : DC5 124) chain E residue 143 type sequence G description BINDING SITE FOR RESIDUE V11 E 301 source : DC5 125) chain E residue 144 type sequence S description BINDING SITE FOR RESIDUE V11 E 301 source : DC5 126) chain E residue 145 type sequence W description BINDING SITE FOR RESIDUE V11 E 301 source : DC5 127) chain E residue 186 type sequence Y description BINDING SITE FOR RESIDUE V11 E 301 source : DC5 128) chain E residue 188 type sequence C description BINDING SITE FOR RESIDUE V11 E 301 source : DC5 129) chain E residue 193 type sequence Y description BINDING SITE FOR RESIDUE V11 E 301 source : DC5 130) chain E residue 40 type sequence K description BINDING SITE FOR RESIDUE CL E 501 source : DC6 131) chain A residue 116 type sequence I description BINDING SITE FOR RESIDUE CL E 502 source : DC7 132) chain E residue 141 type sequence K description BINDING SITE FOR RESIDUE SO4 E 601 source : DC8 133) chain E residue 182 type sequence Q description BINDING SITE FOR RESIDUE SO4 E 601 source : DC8 134) chain E residue 197 type sequence N description BINDING SITE FOR RESIDUE SO4 E 601 source : DC8 135) chain D residue 126 type sequence D description BINDING SITE FOR RESIDUE SO4 E 602 source : DC9 136) chain E residue 167 type sequence Y description BINDING SITE FOR RESIDUE SO4 E 602 source : DC9 137) chain E residue 169 type sequence S description BINDING SITE FOR RESIDUE SO4 E 602 source : DC9 138) chain E residue 1 type sequence Q description BINDING SITE FOR RESIDUE SO4 E 603 source : EC1 139) chain E residue 2 type sequence A description BINDING SITE FOR RESIDUE SO4 E 603 source : EC1 140) chain E residue 3 type sequence N description BINDING SITE FOR RESIDUE SO4 E 603 source : EC1 141) chain D residue 91 type sequence Y description BINDING SITE FOR RESIDUE SO4 E 604 source : EC2 142) chain D residue 92 type sequence S description BINDING SITE FOR RESIDUE SO4 E 604 source : EC2 143) chain E residue 36 type sequence Q description BINDING SITE FOR RESIDUE SO4 E 604 source : EC2 144) chain E residue 165 type sequence S description BINDING SITE FOR RESIDUE SO4 E 604 source : EC2 145) chain E residue 167 type sequence Y description BINDING SITE FOR RESIDUE SO4 E 604 source : EC2 146) chain A residue 167 type sequence Y description BINDING SITE FOR RESIDUE SO4 E 605 source : EC3 147) chain A residue 169 type sequence S description BINDING SITE FOR RESIDUE SO4 E 605 source : EC3 148) chain E residue 126 type sequence D description BINDING SITE FOR RESIDUE SO4 E 605 source : EC3

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