eF-site ID 2y43-AB
PDB Code 2y43
Chain A, B

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Title Rad18 ubiquitin ligase RING domain structure
Classification LIGASE
Compound E3 UBIQUITIN-PROTEIN LIGASE RAD18
Source Homo sapiens (Human) (RAD18_HUMAN)
Sequence A:  RWPPGLAVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCS
LCIRKFLSYKTQCPTCCVTVTEPDLKNNRILDELVKSLNF
ARNHLLQFA
B:  SRWPPGLAVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYC
SLCIRKFLSYKTQCPTCCVTVTEPDLKNNRILDELVKSLN
FARNHLLQF
Description (1)  E3 UBIQUITIN-PROTEIN LIGASE RAD18 (E.C.6.3.2.-)


Functional site

1) chain A
residue 41
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1097
source : AC1

2) chain A
residue 43
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 1097
source : AC1

3) chain A
residue 60
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1097
source : AC1

4) chain A
residue 63
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1097
source : AC1

5) chain A
residue 25
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1098
source : AC2

6) chain A
residue 28
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1098
source : AC2

7) chain A
residue 46
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1098
source : AC2

8) chain A
residue 49
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 1098
source : AC2

9) chain B
residue 41
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 1096
source : AC3

10) chain B
residue 43
type
sequence H
description BINDING SITE FOR RESIDUE ZN B 1096
source : AC3

11) chain B
residue 60
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 1096
source : AC3

12) chain B
residue 63
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 1096
source : AC3

13) chain B
residue 25
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 1097
source : AC4

14) chain B
residue 28
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 1097
source : AC4

15) chain B
residue 46
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 1097
source : AC4

16) chain B
residue 49
type
sequence C
description BINDING SITE FOR RESIDUE ZN B 1097
source : AC4

17) chain A
residue 41-50
type prosite
sequence CSHNYCSLCI
description ZF_RING_1 Zinc finger RING-type signature. CsHnYCslCI
source prosite : PS00518

18) chain A
residue 25-64
type ZN_FING
sequence CGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTCC
description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
source Swiss-Prot : SWS_FT_FI1

19) chain B
residue 25-64
type ZN_FING
sequence CGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTCC
description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175
source Swiss-Prot : SWS_FT_FI1


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