eF-site ID 2y1w-D PDB Code 2y1w Chain D click to enlarge Title CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR Classification TRANSFERASE Compound HISTONE-ARGININE METHYLTRANSFERASE CARM1 Source null (CARM1_HUMAN) Sequence D:  SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQR AILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVE ASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDII ISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHL APFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPF KFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTH WYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVA QVDQTGSKSSNLLDLKNPFFRYTG Description (1)  HISTONE-ARGININE METHYLTRANSFERASE CARM1 (E.C.2.1.1.125) Functional site 1) chain D residue 151 type sequence F description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 2) chain D residue 154 type sequence Y description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 3) chain D residue 160 type sequence Q description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 4) chain D residue 163 type sequence M description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 5) chain D residue 169 type sequence R description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 6) chain D residue 193 type sequence G description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 7) chain D residue 194 type sequence C description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 8) chain D residue 195 type sequence G description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 9) chain D residue 198 type sequence I description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 10) chain D residue 199 type sequence L description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 11) chain D residue 215 type sequence E description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 12) chain D residue 216 type sequence A description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 13) chain D residue 241 type sequence G description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 14) chain D residue 242 type sequence K description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 15) chain D residue 243 type sequence V description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 16) chain D residue 244 type sequence E description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 17) chain D residue 258 type sequence E description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 18) chain D residue 269 type sequence M description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 19) chain D residue 272 type sequence S description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 20) chain D residue 146 type sequence S description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 21) chain D residue 150 type sequence Y description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 22) chain D residue 153 type sequence F description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 23) chain D residue 154 type sequence Y description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 24) chain D residue 258 type sequence E description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 25) chain D residue 259 type sequence P description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 26) chain D residue 260 type sequence M description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 27) chain D residue 262 type sequence Y description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 28) chain D residue 266 type sequence N description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 29) chain D residue 267 type sequence E description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 30) chain D residue 415 type sequence H description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 31) chain D residue 416 type sequence W description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 32) chain D residue 446 type sequence R description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 33) chain D residue 447 type sequence Q description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 34) chain D residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022 source Swiss-Prot : SWS_FT_FI3 35) chain D residue 160 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 36) chain D residue 169 type BINDING sequence R description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 37) chain D residue 193 type BINDING sequence G description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 38) chain D residue 215 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 39) chain D residue 244 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 40) chain D residue 272 type BINDING sequence S description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 41) chain D residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2

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