eF-site ID 2y1w-C PDB Code 2y1w Chain C click to enlarge Title CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR Classification TRANSFERASE Compound HISTONE-ARGININE METHYLTRANSFERASE CARM1 Source Homo sapiens (Human) (CARM1_HUMAN) Sequence C:  SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQR AILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVE ASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDII ISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHL APFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPF KFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTH WYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVA QVDQTGSKSSNLLDLKNPFFRYTG Description Functional site 1) chain C residue 150 type sequence Y description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 2) chain C residue 151 type sequence F description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 3) chain C residue 154 type sequence Y description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 4) chain C residue 160 type sequence Q description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 5) chain C residue 163 type sequence M description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 6) chain C residue 169 type sequence R description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 7) chain C residue 193 type sequence G description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 8) chain C residue 194 type sequence C description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 9) chain C residue 195 type sequence G description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 10) chain C residue 198 type sequence I description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 11) chain C residue 215 type sequence E description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 12) chain C residue 216 type sequence A description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 13) chain C residue 241 type sequence G description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 14) chain C residue 242 type sequence K description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 15) chain C residue 243 type sequence V description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 16) chain C residue 244 type sequence E description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 17) chain C residue 258 type sequence E description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 18) chain C residue 269 type sequence M description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 19) chain C residue 272 type sequence S description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 20) chain C residue 146 type sequence S description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 21) chain C residue 150 type sequence Y description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 22) chain C residue 153 type sequence F description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 23) chain C residue 154 type sequence Y description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 24) chain C residue 258 type sequence E description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 25) chain C residue 259 type sequence P description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 26) chain C residue 260 type sequence M description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 27) chain C residue 262 type sequence Y description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 28) chain C residue 266 type sequence N description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 29) chain C residue 267 type sequence E description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 30) chain C residue 269 type sequence M description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 31) chain C residue 415 type sequence H description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 32) chain C residue 416 type sequence W description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 33) chain C residue 446 type sequence R description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 34) chain C residue 447 type sequence Q description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 35) chain C residue 160 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 36) chain C residue 169 type BINDING sequence R description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 37) chain C residue 193 type BINDING sequence G description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 38) chain C residue 215 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 39) chain C residue 244 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 40) chain C residue 272 type BINDING sequence S description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 41) chain C residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2 42) chain C residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022 source Swiss-Prot : SWS_FT_FI3

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