eF-site ID 2y1w-B PDB Code 2y1w Chain B click to enlarge Title CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR Classification TRANSFERASE Compound HISTONE-ARGININE METHYLTRANSFERASE CARM1 Source Homo sapiens (Human) (CARM1_HUMAN) Sequence B:  SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQR AILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVE ASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDII ISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHL APFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPF KFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTH WYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVA QVDQTGSKSSNLLDLKNPFFRYTG Description Functional site 1) chain B residue 150 type sequence Y description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 2) chain B residue 151 type sequence F description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 3) chain B residue 154 type sequence Y description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 4) chain B residue 160 type sequence Q description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 5) chain B residue 163 type sequence M description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 6) chain B residue 169 type sequence R description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 7) chain B residue 193 type sequence G description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 8) chain B residue 194 type sequence C description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 9) chain B residue 195 type sequence G description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 10) chain B residue 198 type sequence I description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 11) chain B residue 199 type sequence L description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 12) chain B residue 215 type sequence E description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 13) chain B residue 216 type sequence A description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 14) chain B residue 241 type sequence G description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 15) chain B residue 242 type sequence K description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 16) chain B residue 243 type sequence V description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 17) chain B residue 244 type sequence E description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 18) chain B residue 258 type sequence E description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 19) chain B residue 269 type sequence M description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 20) chain B residue 272 type sequence S description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 21) chain B residue 146 type sequence S description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 22) chain B residue 150 type sequence Y description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 23) chain B residue 153 type sequence F description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 24) chain B residue 154 type sequence Y description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 25) chain B residue 258 type sequence E description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 26) chain B residue 259 type sequence P description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 27) chain B residue 260 type sequence M description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 28) chain B residue 262 type sequence Y description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 29) chain B residue 266 type sequence N description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 30) chain B residue 267 type sequence E description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 31) chain B residue 269 type sequence M description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 32) chain B residue 415 type sequence H description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 33) chain B residue 416 type sequence W description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 34) chain B residue 446 type sequence R description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 35) chain B residue 447 type sequence Q description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 36) chain B residue 215 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 37) chain B residue 244 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 272 type BINDING sequence S description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 160 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 40) chain B residue 169 type BINDING sequence R description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 41) chain B residue 193 type BINDING sequence G description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2 43) chain B residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022 source Swiss-Prot : SWS_FT_FI3

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