eF-site ID 2y1w-ABCD PDB Code 2y1w Chain A, B, C, D click to enlarge Title CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR Classification TRANSFERASE Compound HISTONE-ARGININE METHYLTRANSFERASE CARM1 Source Homo sapiens (Human) (CARM1_HUMAN) Sequence A:  SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQR AILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVE ASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDII ISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHL APFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPF KFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTH WYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVA QVDQTGSKSSNLLDLKNPFFRYTG B:  SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQR AILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVE ASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDII ISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHL APFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPF KFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTH WYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVA QVDQTGSKSSNLLDLKNPFFRYTG C:  SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQR AILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVE ASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDII ISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHL APFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPF KFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTH WYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVA QVDQTGSKSSNLLDLKNPFFRYTG D:  SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQR AILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVE ASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDII ISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHL APFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEY FRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPF KFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTH WYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVA QVDQTGSKSSNLLDLKNPFFRYTG Description (1)  HISTONE-ARGININE METHYLTRANSFERASE CARM1 (E.C.2.1.1.125) Functional site 1) chain A residue 150 type sequence Y description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 2) chain A residue 151 type sequence F description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 3) chain A residue 154 type sequence Y description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 4) chain A residue 160 type sequence Q description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 5) chain A residue 163 type sequence M description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 6) chain A residue 169 type sequence R description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 7) chain A residue 193 type sequence G description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 8) chain A residue 194 type sequence C description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 9) chain A residue 195 type sequence G description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 10) chain A residue 198 type sequence I description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 11) chain A residue 199 type sequence L description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 12) chain A residue 215 type sequence E description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 13) chain A residue 216 type sequence A description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 14) chain A residue 241 type sequence G description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 15) chain A residue 242 type sequence K description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 16) chain A residue 243 type sequence V description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 17) chain A residue 244 type sequence E description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 18) chain A residue 258 type sequence E description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 19) chain A residue 269 type sequence M description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 20) chain A residue 272 type sequence S description BINDING SITE FOR RESIDUE SFG A 1001 source : AC1 21) chain B residue 150 type sequence Y description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 22) chain B residue 151 type sequence F description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 23) chain B residue 154 type sequence Y description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 24) chain B residue 160 type sequence Q description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 25) chain B residue 163 type sequence M description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 26) chain B residue 169 type sequence R description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 27) chain B residue 193 type sequence G description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 28) chain B residue 194 type sequence C description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 29) chain B residue 195 type sequence G description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 30) chain B residue 198 type sequence I description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 31) chain B residue 199 type sequence L description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 32) chain B residue 215 type sequence E description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 33) chain B residue 216 type sequence A description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 34) chain B residue 241 type sequence G description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 35) chain B residue 242 type sequence K description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 36) chain B residue 243 type sequence V description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 37) chain B residue 244 type sequence E description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 38) chain B residue 258 type sequence E description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 39) chain B residue 269 type sequence M description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 40) chain B residue 272 type sequence S description BINDING SITE FOR RESIDUE SFG B 1001 source : AC2 41) chain C residue 150 type sequence Y description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 42) chain C residue 151 type sequence F description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 43) chain C residue 154 type sequence Y description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 44) chain C residue 160 type sequence Q description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 45) chain C residue 163 type sequence M description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 46) chain C residue 169 type sequence R description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 47) chain C residue 193 type sequence G description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 48) chain C residue 194 type sequence C description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 49) chain C residue 195 type sequence G description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 50) chain C residue 198 type sequence I description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 51) chain C residue 215 type sequence E description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 52) chain C residue 216 type sequence A description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 53) chain C residue 241 type sequence G description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 54) chain C residue 242 type sequence K description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 55) chain C residue 243 type sequence V description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 56) chain C residue 244 type sequence E description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 57) chain C residue 258 type sequence E description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 58) chain C residue 269 type sequence M description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 59) chain C residue 272 type sequence S description BINDING SITE FOR RESIDUE SFG C 1001 source : AC3 60) chain D residue 151 type sequence F description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 61) chain D residue 154 type sequence Y description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 62) chain D residue 160 type sequence Q description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 63) chain D residue 163 type sequence M description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 64) chain D residue 169 type sequence R description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 65) chain D residue 193 type sequence G description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 66) chain D residue 194 type sequence C description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 67) chain D residue 195 type sequence G description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 68) chain D residue 198 type sequence I description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 69) chain D residue 199 type sequence L description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 70) chain D residue 215 type sequence E description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 71) chain D residue 216 type sequence A description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 72) chain D residue 241 type sequence G description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 73) chain D residue 242 type sequence K description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 74) chain D residue 243 type sequence V description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 75) chain D residue 244 type sequence E description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 76) chain D residue 258 type sequence E description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 77) chain D residue 269 type sequence M description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 78) chain D residue 272 type sequence S description BINDING SITE FOR RESIDUE SFG D 1001 source : AC4 79) chain A residue 146 type sequence S description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 80) chain A residue 149 type sequence Q description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 81) chain A residue 150 type sequence Y description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 82) chain A residue 153 type sequence F description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 83) chain A residue 154 type sequence Y description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 84) chain A residue 258 type sequence E description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 85) chain A residue 259 type sequence P description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 86) chain A residue 260 type sequence M description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 87) chain A residue 262 type sequence Y description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 88) chain A residue 266 type sequence N description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 89) chain A residue 267 type sequence E description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 90) chain A residue 269 type sequence M description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 91) chain A residue 415 type sequence H description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 92) chain A residue 416 type sequence W description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 93) chain A residue 446 type sequence R description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 94) chain A residue 447 type sequence Q description BINDING SITE FOR RESIDUE 849 A 1005 source : AC5 95) chain B residue 146 type sequence S description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 96) chain B residue 150 type sequence Y description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 97) chain B residue 153 type sequence F description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 98) chain B residue 154 type sequence Y description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 99) chain B residue 258 type sequence E description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 100) chain B residue 259 type sequence P description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 101) chain B residue 260 type sequence M description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 102) chain B residue 262 type sequence Y description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 103) chain B residue 266 type sequence N description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 104) chain B residue 267 type sequence E description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 105) chain B residue 269 type sequence M description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 106) chain B residue 415 type sequence H description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 107) chain B residue 416 type sequence W description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 108) chain B residue 446 type sequence R description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 109) chain B residue 447 type sequence Q description BINDING SITE FOR RESIDUE 849 B 1005 source : AC6 110) chain C residue 146 type sequence S description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 111) chain C residue 150 type sequence Y description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 112) chain C residue 153 type sequence F description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 113) chain C residue 154 type sequence Y description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 114) chain C residue 258 type sequence E description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 115) chain C residue 259 type sequence P description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 116) chain C residue 260 type sequence M description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 117) chain C residue 262 type sequence Y description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 118) chain C residue 266 type sequence N description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 119) chain C residue 267 type sequence E description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 120) chain C residue 269 type sequence M description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 121) chain C residue 415 type sequence H description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 122) chain C residue 416 type sequence W description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 123) chain C residue 446 type sequence R description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 124) chain C residue 447 type sequence Q description BINDING SITE FOR RESIDUE 849 C 1005 source : AC7 125) chain D residue 146 type sequence S description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 126) chain D residue 150 type sequence Y description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 127) chain D residue 153 type sequence F description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 128) chain D residue 154 type sequence Y description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 129) chain D residue 258 type sequence E description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 130) chain D residue 259 type sequence P description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 131) chain D residue 260 type sequence M description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 132) chain D residue 262 type sequence Y description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 133) chain D residue 266 type sequence N description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 134) chain D residue 267 type sequence E description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 135) chain D residue 415 type sequence H description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 136) chain D residue 416 type sequence W description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 137) chain D residue 446 type sequence R description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 138) chain D residue 447 type sequence Q description BINDING SITE FOR RESIDUE 849 D 1005 source : AC8 139) chain A residue 160 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 140) chain B residue 215 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 141) chain B residue 244 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 142) chain B residue 272 type BINDING sequence S description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 143) chain C residue 160 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 144) chain C residue 169 type BINDING sequence R description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 145) chain C residue 193 type BINDING sequence G description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 146) chain C residue 215 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 147) chain C residue 244 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 148) chain C residue 272 type BINDING sequence S description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 149) chain D residue 160 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 150) chain A residue 169 type BINDING sequence R description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 151) chain D residue 169 type BINDING sequence R description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 152) chain D residue 193 type BINDING sequence G description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 153) chain D residue 215 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 154) chain D residue 244 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 155) chain D residue 272 type BINDING sequence S description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 156) chain A residue 193 type BINDING sequence G description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 157) chain A residue 215 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 158) chain A residue 244 type BINDING sequence E description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 159) chain A residue 272 type BINDING sequence S description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 160) chain B residue 160 type BINDING sequence Q description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 161) chain B residue 169 type BINDING sequence R description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 162) chain B residue 193 type BINDING sequence G description BINDING => ECO:0000305|PubMed:21410432 source Swiss-Prot : SWS_FT_FI1 163) chain A residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2 164) chain B residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2 165) chain C residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2 166) chain D residue 217 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:19843527 source Swiss-Prot : SWS_FT_FI2 167) chain A residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022 source Swiss-Prot : SWS_FT_FI3 168) chain B residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022 source Swiss-Prot : SWS_FT_FI3 169) chain C residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022 source Swiss-Prot : SWS_FT_FI3 170) chain D residue 228 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:34480022 source Swiss-Prot : SWS_FT_FI3

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