eF-site ID 2y1n-ABCD PDB Code 2y1n Chain A, B, C, D click to enlarge Title Structure of c-Cbl-ZAP-70 peptide complex Classification LIGASE/TRANSFERASE Compound E3 UBIQUITIN-PROTEIN LIGASE Source null (ZAP70_HUMAN) Sequence A:  DKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDT YQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTIS LFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPS GLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHE VHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPW SSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSY IFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDG FREGFYLFPDGRNQNPDLTGLCEKVTQEQYELYCEMGSTF QLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPF CRCEIKGTEPIVVDPFD B:  SDGXTPEPA C:  DKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDT YQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTIS LFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPS GLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHE VHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPW SSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSY IFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDG FREGFYLFPDGRNQNPDLTGLCEDHIKVTQEQYELYCEMG STFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQG CPFCRCEIKGTEPIVVDPFD D:  SDGXTPEPA Description Functional site 1) chain A residue 381 type sequence C description BINDING SITE FOR RESIDUE ZN A 1436 source : AC1 2) chain A residue 384 type sequence C description BINDING SITE FOR RESIDUE ZN A 1436 source : AC1 3) chain A residue 401 type sequence C description BINDING SITE FOR RESIDUE ZN A 1436 source : AC1 4) chain A residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN A 1436 source : AC1 5) chain A residue 396 type sequence C description BINDING SITE FOR RESIDUE ZN A 1437 source : AC2 6) chain A residue 398 type sequence H description BINDING SITE FOR RESIDUE ZN A 1437 source : AC2 7) chain A residue 416 type sequence C description BINDING SITE FOR RESIDUE ZN A 1437 source : AC2 8) chain A residue 419 type sequence C description BINDING SITE FOR RESIDUE ZN A 1437 source : AC2 9) chain C residue 381 type sequence C description BINDING SITE FOR RESIDUE ZN C 1436 source : AC3 10) chain C residue 384 type sequence C description BINDING SITE FOR RESIDUE ZN C 1436 source : AC3 11) chain C residue 401 type sequence C description BINDING SITE FOR RESIDUE ZN C 1436 source : AC3 12) chain C residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN C 1436 source : AC3 13) chain C residue 396 type sequence C description BINDING SITE FOR RESIDUE ZN C 1437 source : AC4 14) chain C residue 398 type sequence H description BINDING SITE FOR RESIDUE ZN C 1437 source : AC4 15) chain C residue 416 type sequence C description BINDING SITE FOR RESIDUE ZN C 1437 source : AC4 16) chain C residue 419 type sequence C description BINDING SITE FOR RESIDUE ZN C 1437 source : AC4 17) chain A residue 229 type sequence D description BINDING SITE FOR RESIDUE CA A 1438 source : AC5 18) chain A residue 231 type sequence T description BINDING SITE FOR RESIDUE CA A 1438 source : AC5 19) chain A residue 233 type sequence N description BINDING SITE FOR RESIDUE CA A 1438 source : AC5 20) chain A residue 235 type sequence Y description BINDING SITE FOR RESIDUE CA A 1438 source : AC5 21) chain A residue 240 type sequence E description BINDING SITE FOR RESIDUE CA A 1438 source : AC5 22) chain C residue 229 type sequence D description BINDING SITE FOR RESIDUE CA C 1438 source : AC6 23) chain C residue 231 type sequence T description BINDING SITE FOR RESIDUE CA C 1438 source : AC6 24) chain C residue 233 type sequence N description BINDING SITE FOR RESIDUE CA C 1438 source : AC6 25) chain C residue 235 type sequence Y description BINDING SITE FOR RESIDUE CA C 1438 source : AC6 26) chain C residue 240 type sequence E description BINDING SITE FOR RESIDUE CA C 1438 source : AC6 27) chain A residue 396-405 type prosite sequence CGHLMCTSCL description ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL source prosite : PS00518 28) chain D residue 4 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:15144186 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 4 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:15144186 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 7 type MOD_RES sequence X description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 31) chain C residue 240 type MOD_RES sequence E description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 233 type MOD_RES sequence N description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 235 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 240 type MOD_RES sequence E description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 35) chain C residue 229 type MOD_RES sequence D description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 36) chain C residue 231 type MOD_RES sequence T description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 37) chain C residue 233 type MOD_RES sequence N description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 38) chain C residue 235 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 39) chain B residue 7 type MOD_RES sequence X description Phosphotyrosine => ECO:0000269|PubMed:8943331, ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI2 40) chain C residue 371 type MOD_RES sequence Y description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 41) chain A residue 371 type MOD_RES sequence Y description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 42) chain C residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 43) chain A residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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