eF-site ID 2y1m-E PDB Code 2y1m Chain E click to enlarge Title Structure of native c-Cbl Classification LIGASE Compound E3 UBIQUITIN-PROTEIN LIGASE Source Homo sapiens (Human) (CBL_HUMAN) Sequence E:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ ALIDGFREGFYLFPDGRNQNPDLTGLCHIKVTQEQYELYC EMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESE GQGCPFCRCEIKGTEPIVVDPFD Description Functional site 1) chain E residue 381 type sequence C description BINDING SITE FOR RESIDUE ZN E 1436 source : AC9 2) chain E residue 383 type sequence I description BINDING SITE FOR RESIDUE ZN E 1436 source : AC9 3) chain E residue 384 type sequence C description BINDING SITE FOR RESIDUE ZN E 1436 source : AC9 4) chain E residue 401 type sequence C description BINDING SITE FOR RESIDUE ZN E 1436 source : AC9 5) chain E residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN E 1436 source : AC9 6) chain E residue 396 type sequence C description BINDING SITE FOR RESIDUE ZN E 1437 source : BC1 7) chain E residue 398 type sequence H description BINDING SITE FOR RESIDUE ZN E 1437 source : BC1 8) chain E residue 416 type sequence C description BINDING SITE FOR RESIDUE ZN E 1437 source : BC1 9) chain E residue 419 type sequence C description BINDING SITE FOR RESIDUE ZN E 1437 source : BC1 10) chain E residue 229 type sequence D description BINDING SITE FOR RESIDUE CA E 1438 source : BC8 11) chain E residue 231 type sequence T description BINDING SITE FOR RESIDUE CA E 1438 source : BC8 12) chain E residue 233 type sequence N description BINDING SITE FOR RESIDUE CA E 1438 source : BC8 13) chain E residue 235 type sequence Y description BINDING SITE FOR RESIDUE CA E 1438 source : BC8 14) chain E residue 240 type sequence E description BINDING SITE FOR RESIDUE CA E 1438 source : BC8 15) chain E residue 371 type MOD_RES sequence Y description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 16) chain E residue 381-420 type ZN_FING sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1 17) chain E residue 229 type BINDING sequence D description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 18) chain E residue 231 type BINDING sequence T description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 19) chain E residue 233 type BINDING sequence N description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 20) chain E residue 235 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 21) chain E residue 240 type BINDING sequence E description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 22) chain E residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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