eF-site ID 2y1m-C PDB Code 2y1m Chain C click to enlarge Title Structure of native c-Cbl Classification LIGASE Compound E3 UBIQUITIN-PROTEIN LIGASE Source Homo sapiens (Human) (CBL_HUMAN) Sequence C:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ ALIDGFREGFYLFPDGRNQNPDLTGLCEDHIKVTQEQYEL YCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQE SEGQGCPFCRCEIKGTEPIVVDPFD Description Functional site 1) chain C residue 381 type sequence C description BINDING SITE FOR RESIDUE ZN C 1436 source : AC5 2) chain C residue 384 type sequence C description BINDING SITE FOR RESIDUE ZN C 1436 source : AC5 3) chain C residue 401 type sequence C description BINDING SITE FOR RESIDUE ZN C 1436 source : AC5 4) chain C residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN C 1436 source : AC5 5) chain C residue 396 type sequence C description BINDING SITE FOR RESIDUE ZN C 1437 source : AC6 6) chain C residue 398 type sequence H description BINDING SITE FOR RESIDUE ZN C 1437 source : AC6 7) chain C residue 416 type sequence C description BINDING SITE FOR RESIDUE ZN C 1437 source : AC6 8) chain C residue 419 type sequence C description BINDING SITE FOR RESIDUE ZN C 1437 source : AC6 9) chain C residue 229 type sequence D description BINDING SITE FOR RESIDUE CA C 1438 source : BC7 10) chain C residue 231 type sequence T description BINDING SITE FOR RESIDUE CA C 1438 source : BC7 11) chain C residue 233 type sequence N description BINDING SITE FOR RESIDUE CA C 1438 source : BC7 12) chain C residue 235 type sequence Y description BINDING SITE FOR RESIDUE CA C 1438 source : BC7 13) chain C residue 240 type sequence E description BINDING SITE FOR RESIDUE CA C 1438 source : BC7 14) chain C residue 371 type MOD_RES sequence Y description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 15) chain C residue 381-420 type ZN_FING sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1 16) chain C residue 229 type BINDING sequence D description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 17) chain C residue 231 type BINDING sequence T description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 18) chain C residue 233 type BINDING sequence N description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 19) chain C residue 235 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 20) chain C residue 240 type BINDING sequence E description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 21) chain C residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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