eF-site ID 2y1m-B PDB Code 2y1m Chain B click to enlarge Title Structure of native c-Cbl Classification LIGASE Compound E3 UBIQUITIN-PROTEIN LIGASE Source null (CBL_HUMAN) Sequence B:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ ALIDGFREGFYLFPDGRNQNPDLTGLCEPHIKVTQEQYEL YCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQE SEGQGCPFCRCEIKGTEPIVVDPFD Description Functional site 1) chain B residue 381 type sequence C description BINDING SITE FOR RESIDUE ZN B 1436 source : AC3 2) chain B residue 384 type sequence C description BINDING SITE FOR RESIDUE ZN B 1436 source : AC3 3) chain B residue 401 type sequence C description BINDING SITE FOR RESIDUE ZN B 1436 source : AC3 4) chain B residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN B 1436 source : AC3 5) chain B residue 396 type sequence C description BINDING SITE FOR RESIDUE ZN B 1437 source : AC4 6) chain B residue 398 type sequence H description BINDING SITE FOR RESIDUE ZN B 1437 source : AC4 7) chain B residue 416 type sequence C description BINDING SITE FOR RESIDUE ZN B 1437 source : AC4 8) chain B residue 419 type sequence C description BINDING SITE FOR RESIDUE ZN B 1437 source : AC4 9) chain B residue 229 type sequence D description BINDING SITE FOR RESIDUE CA B 1438 source : BC4 10) chain B residue 231 type sequence T description BINDING SITE FOR RESIDUE CA B 1438 source : BC4 11) chain B residue 233 type sequence N description BINDING SITE FOR RESIDUE CA B 1438 source : BC4 12) chain B residue 235 type sequence Y description BINDING SITE FOR RESIDUE CA B 1438 source : BC4 13) chain B residue 240 type sequence E description BINDING SITE FOR RESIDUE CA B 1438 source : BC4 14) chain B residue 371 type MOD_RES sequence Y description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 15) chain B residue 240 type BINDING sequence E description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 16) chain B residue 231 type BINDING sequence T description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 17) chain B residue 233 type BINDING sequence N description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 18) chain B residue 235 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 19) chain B residue 229 type BINDING sequence D description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 20) chain B residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 21) chain B residue 381-420 type ZN_FING sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1

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