eF-site ID 2y1m-ABCDEF PDB Code 2y1m Chain A, B, C, D, E, F click to enlarge Title Structure of native c-Cbl Classification LIGASE Compound E3 UBIQUITIN-PROTEIN LIGASE Source Homo sapiens (Human) (CBL_HUMAN) Sequence A:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ ALIDGFREGFYLFPDGRNQNPDLTGLCDHIKVTQEQYELY CEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQES EGQGCPFCRCEIKGTEPIVVDPFD B:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ ALIDGFREGFYLFPDGRNQNPDLTGLCEPHIKVTQEQYEL YCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQE SEGQGCPFCRCEIKGTEPIVVDPFD C:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ ALIDGFREGFYLFPDGRNQNPDLTGLCEDHIKVTQEQYEL YCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQE SEGQGCPFCRCEIKGTEPIVVDPFD D:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ ALIDGFREGFYLFPDGRNQNPDLTGLCEDHIKVTQEQYEL YCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQE SEGQGCPFCRCEIKGTEPIVVDPFD E:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ ALIDGFREGFYLFPDGRNQNPDLTGLCHIKVTQEQYELYC EMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESE GQGCPFCRCEIKGTEPIVVDPFD F:  PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILD LLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKT KQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFR QALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTR LFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQ ALIDGFREGFYLFPDGRNQNPDLTGLCDHIKVTQEQYELY CEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQES EGQGCPFCRCEIKGTEPIVVDPFD Description Functional site 1) chain A residue 381 type sequence C description BINDING SITE FOR RESIDUE ZN A 1436 source : AC1 2) chain A residue 384 type sequence C description BINDING SITE FOR RESIDUE ZN A 1436 source : AC1 3) chain A residue 401 type sequence C description BINDING SITE FOR RESIDUE ZN A 1436 source : AC1 4) chain A residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN A 1436 source : AC1 5) chain A residue 396 type sequence C description BINDING SITE FOR RESIDUE ZN A 1437 source : AC2 6) chain A residue 398 type sequence H description BINDING SITE FOR RESIDUE ZN A 1437 source : AC2 7) chain A residue 416 type sequence C description BINDING SITE FOR RESIDUE ZN A 1437 source : AC2 8) chain A residue 419 type sequence C description BINDING SITE FOR RESIDUE ZN A 1437 source : AC2 9) chain B residue 381 type sequence C description BINDING SITE FOR RESIDUE ZN B 1436 source : AC3 10) chain B residue 384 type sequence C description BINDING SITE FOR RESIDUE ZN B 1436 source : AC3 11) chain B residue 401 type sequence C description BINDING SITE FOR RESIDUE ZN B 1436 source : AC3 12) chain B residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN B 1436 source : AC3 13) chain B residue 396 type sequence C description BINDING SITE FOR RESIDUE ZN B 1437 source : AC4 14) chain B residue 398 type sequence H description BINDING SITE FOR RESIDUE ZN B 1437 source : AC4 15) chain B residue 416 type sequence C description BINDING SITE FOR RESIDUE ZN B 1437 source : AC4 16) chain B residue 419 type sequence C description BINDING SITE FOR RESIDUE ZN B 1437 source : AC4 17) chain C residue 381 type sequence C description BINDING SITE FOR RESIDUE ZN C 1436 source : AC5 18) chain C residue 384 type sequence C description BINDING SITE FOR RESIDUE ZN C 1436 source : AC5 19) chain C residue 401 type sequence C description BINDING SITE FOR RESIDUE ZN C 1436 source : AC5 20) chain C residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN C 1436 source : AC5 21) chain C residue 396 type sequence C description BINDING SITE FOR RESIDUE ZN C 1437 source : AC6 22) chain C residue 398 type sequence H description BINDING SITE FOR RESIDUE ZN C 1437 source : AC6 23) chain C residue 416 type sequence C description BINDING SITE FOR RESIDUE ZN C 1437 source : AC6 24) chain C residue 419 type sequence C description BINDING SITE FOR RESIDUE ZN C 1437 source : AC6 25) chain D residue 381 type sequence C description BINDING SITE FOR RESIDUE ZN D 1436 source : AC7 26) chain D residue 384 type sequence C description BINDING SITE FOR RESIDUE ZN D 1436 source : AC7 27) chain D residue 401 type sequence C description BINDING SITE FOR RESIDUE ZN D 1436 source : AC7 28) chain D residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN D 1436 source : AC7 29) chain D residue 396 type sequence C description BINDING SITE FOR RESIDUE ZN D 1437 source : AC8 30) chain D residue 398 type sequence H description BINDING SITE FOR RESIDUE ZN D 1437 source : AC8 31) chain D residue 416 type sequence C description BINDING SITE FOR RESIDUE ZN D 1437 source : AC8 32) chain D residue 419 type sequence C description BINDING SITE FOR RESIDUE ZN D 1437 source : AC8 33) chain E residue 381 type sequence C description BINDING SITE FOR RESIDUE ZN E 1436 source : AC9 34) chain E residue 383 type sequence I description BINDING SITE FOR RESIDUE ZN E 1436 source : AC9 35) chain E residue 384 type sequence C description BINDING SITE FOR RESIDUE ZN E 1436 source : AC9 36) chain E residue 401 type sequence C description BINDING SITE FOR RESIDUE ZN E 1436 source : AC9 37) chain E residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN E 1436 source : AC9 38) chain E residue 396 type sequence C description BINDING SITE FOR RESIDUE ZN E 1437 source : BC1 39) chain E residue 398 type sequence H description BINDING SITE FOR RESIDUE ZN E 1437 source : BC1 40) chain E residue 416 type sequence C description BINDING SITE FOR RESIDUE ZN E 1437 source : BC1 41) chain E residue 419 type sequence C description BINDING SITE FOR RESIDUE ZN E 1437 source : BC1 42) chain F residue 381 type sequence C description BINDING SITE FOR RESIDUE ZN F 1436 source : BC2 43) chain F residue 384 type sequence C description BINDING SITE FOR RESIDUE ZN F 1436 source : BC2 44) chain F residue 401 type sequence C description BINDING SITE FOR RESIDUE ZN F 1436 source : BC2 45) chain F residue 404 type sequence C description BINDING SITE FOR RESIDUE ZN F 1436 source : BC2 46) chain F residue 396 type sequence C description BINDING SITE FOR RESIDUE ZN F 1437 source : BC3 47) chain F residue 398 type sequence H description BINDING SITE FOR RESIDUE ZN F 1437 source : BC3 48) chain F residue 416 type sequence C description BINDING SITE FOR RESIDUE ZN F 1437 source : BC3 49) chain F residue 419 type sequence C description BINDING SITE FOR RESIDUE ZN F 1437 source : BC3 50) chain B residue 229 type sequence D description BINDING SITE FOR RESIDUE CA B 1438 source : BC4 51) chain B residue 231 type sequence T description BINDING SITE FOR RESIDUE CA B 1438 source : BC4 52) chain B residue 233 type sequence N description BINDING SITE FOR RESIDUE CA B 1438 source : BC4 53) chain B residue 235 type sequence Y description BINDING SITE FOR RESIDUE CA B 1438 source : BC4 54) chain B residue 240 type sequence E description BINDING SITE FOR RESIDUE CA B 1438 source : BC4 55) chain D residue 229 type sequence D description BINDING SITE FOR RESIDUE CA D 1438 source : BC5 56) chain D residue 231 type sequence T description BINDING SITE FOR RESIDUE CA D 1438 source : BC5 57) chain D residue 233 type sequence N description BINDING SITE FOR RESIDUE CA D 1438 source : BC5 58) chain D residue 235 type sequence Y description BINDING SITE FOR RESIDUE CA D 1438 source : BC5 59) chain D residue 240 type sequence E description BINDING SITE FOR RESIDUE CA D 1438 source : BC5 60) chain A residue 229 type sequence D description BINDING SITE FOR RESIDUE CA A 1438 source : BC6 61) chain A residue 231 type sequence T description BINDING SITE FOR RESIDUE CA A 1438 source : BC6 62) chain A residue 233 type sequence N description BINDING SITE FOR RESIDUE CA A 1438 source : BC6 63) chain A residue 235 type sequence Y description BINDING SITE FOR RESIDUE CA A 1438 source : BC6 64) chain A residue 240 type sequence E description BINDING SITE FOR RESIDUE CA A 1438 source : BC6 65) chain C residue 229 type sequence D description BINDING SITE FOR RESIDUE CA C 1438 source : BC7 66) chain C residue 231 type sequence T description BINDING SITE FOR RESIDUE CA C 1438 source : BC7 67) chain C residue 233 type sequence N description BINDING SITE FOR RESIDUE CA C 1438 source : BC7 68) chain C residue 235 type sequence Y description BINDING SITE FOR RESIDUE CA C 1438 source : BC7 69) chain C residue 240 type sequence E description BINDING SITE FOR RESIDUE CA C 1438 source : BC7 70) chain E residue 229 type sequence D description BINDING SITE FOR RESIDUE CA E 1438 source : BC8 71) chain E residue 231 type sequence T description BINDING SITE FOR RESIDUE CA E 1438 source : BC8 72) chain E residue 233 type sequence N description BINDING SITE FOR RESIDUE CA E 1438 source : BC8 73) chain E residue 235 type sequence Y description BINDING SITE FOR RESIDUE CA E 1438 source : BC8 74) chain E residue 240 type sequence E description BINDING SITE FOR RESIDUE CA E 1438 source : BC8 75) chain F residue 229 type sequence D description BINDING SITE FOR RESIDUE CA F 1438 source : BC9 76) chain F residue 231 type sequence T description BINDING SITE FOR RESIDUE CA F 1438 source : BC9 77) chain F residue 233 type sequence N description BINDING SITE FOR RESIDUE CA F 1438 source : BC9 78) chain F residue 235 type sequence Y description BINDING SITE FOR RESIDUE CA F 1438 source : BC9 79) chain F residue 240 type sequence E description BINDING SITE FOR RESIDUE CA F 1438 source : BC9 80) chain A residue 371 type MOD_RES sequence Y description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 81) chain B residue 371 type MOD_RES sequence Y description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 82) chain C residue 371 type MOD_RES sequence Y description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 83) chain D residue 371 type MOD_RES sequence Y description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 84) chain E residue 371 type MOD_RES sequence Y description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 85) chain F residue 371 type MOD_RES sequence Y description Phosphotyrosine; by INSR => ECO:0000269|PubMed:11997497 source Swiss-Prot : SWS_FT_FI4 86) chain A residue 396-405 type prosite sequence CGHLMCTSCL description ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL source prosite : PS00518 87) chain A residue 381-420 type ZN_FING sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1 88) chain B residue 381-420 type ZN_FING sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1 89) chain C residue 381-420 type ZN_FING sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1 90) chain D residue 381-420 type ZN_FING sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1 91) chain E residue 381-420 type ZN_FING sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1 92) chain F residue 381-420 type ZN_FING sequence CKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCR description RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 source Swiss-Prot : SWS_FT_FI1 93) chain A residue 229 type BINDING sequence D description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 94) chain B residue 240 type BINDING sequence E description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 95) chain C residue 229 type BINDING sequence D description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 96) chain C residue 231 type BINDING sequence T description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 97) chain C residue 233 type BINDING sequence N description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 98) chain C residue 235 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 99) chain C residue 240 type BINDING sequence E description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 100) chain D residue 229 type BINDING sequence D description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 101) chain D residue 231 type BINDING sequence T description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 102) chain D residue 233 type BINDING sequence N description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 103) chain D residue 235 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 104) chain A residue 231 type BINDING sequence T description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 105) chain D residue 240 type BINDING sequence E description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 106) chain E residue 229 type BINDING sequence D description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 107) chain E residue 231 type BINDING sequence T description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 108) chain E residue 233 type BINDING sequence N description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 109) chain E residue 235 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 110) chain E residue 240 type BINDING sequence E description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 111) chain F residue 229 type BINDING sequence D description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 112) chain F residue 231 type BINDING sequence T description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 113) chain F residue 233 type BINDING sequence N description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 114) chain F residue 235 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 115) chain A residue 233 type BINDING sequence N description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 116) chain F residue 240 type BINDING sequence E description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 117) chain A residue 235 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 118) chain A residue 240 type BINDING sequence E description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 119) chain B residue 229 type BINDING sequence D description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 120) chain B residue 231 type BINDING sequence T description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 121) chain B residue 233 type BINDING sequence N description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 122) chain B residue 235 type BINDING sequence Y description BINDING => ECO:0007744|PDB:1B47, ECO:0007744|PDB:2CBL source Swiss-Prot : SWS_FT_FI2 123) chain A residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 124) chain B residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 125) chain C residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 126) chain D residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 127) chain E residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 128) chain F residue 294 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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