eF-site ID 2y1l-ABCDEFGH PDB Code 2y1l Chain A, B, C, D, E, F, G, H click to enlarge Title Caspase-8 in Complex with DARPin-8.4 Classification HYDROLASE/INHIBITOR Compound CASPASE-8 Source Homo sapiens (Human) (2Y1L) Sequence A:  LDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRN GTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQL MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFT GLKCPSLAGKPKVFFIQACQGDNYQKGIPV B:  YIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRE RCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLR KKLVFPS C:  DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNG THLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLM DHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTG LKCPSLAGKPKVFFIQACQGDNYQKGIP D:  TRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSL RERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFT LRKKLVFPSD E:  DLGKKLLEAARAGRDDEVRILMANGADVNAEDASGWTPLH LAAFNGHLEIVEVLLKNGADVNAVDHAGMTPLRLAALFGH LEIVEVLLKNGADVNANDMEGHTPLHLAAMFGHLEIVEVL LKNGADVNAQDKFGKTAFDISIDNGNEDLAEILQKL F:  DLGKKLLEAARAGRDDEVRILMANGADVNAEDASGWTPLH LAAFNGHLEIVEVLLKNGADVNAVDHAGMTPLRLAALFGH LEIVEVLLKNGADVNANDMEGHTPLHLAAMFGHLEIVEVL LKNGADVNAQDKFGKTAFDISIDNGNEDLAEILQKL G:  IETD H:  IETD Description Functional site 1) chain A residue 242 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1372 source : AC1 2) chain A residue 261 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1372 source : AC1 3) chain A residue 262 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1372 source : AC1 4) chain A residue 263 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1372 source : AC1 5) chain A residue 264 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1372 source : AC1 6) chain B residue 414 type sequence N description BINDING SITE FOR RESIDUE EDO B 1479 source : AC2 7) chain B residue 417 type sequence E description BINDING SITE FOR RESIDUE EDO B 1479 source : AC2 8) chain B residue 420 type sequence W description BINDING SITE FOR RESIDUE EDO B 1479 source : AC2 9) chain B residue 453 type sequence K description BINDING SITE FOR RESIDUE EDO B 1479 source : AC2 10) chain H residue 1 type sequence I description BINDING SITE FOR RESIDUE EDO B 1479 source : AC2 11) chain B residue 471 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1480 source : AC3 12) chain B residue 472 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1480 source : AC3 13) chain D residue 448 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 1480 source : AC3 14) chain E residue 144 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1480 source : AC3 15) chain C residue 242 type sequence H description BINDING SITE FOR RESIDUE SO4 C 1371 source : AC4 16) chain C residue 261 type sequence N description BINDING SITE FOR RESIDUE SO4 C 1371 source : AC4 17) chain C residue 262 type sequence G description BINDING SITE FOR RESIDUE SO4 C 1371 source : AC4 18) chain C residue 263 type sequence T description BINDING SITE FOR RESIDUE SO4 C 1371 source : AC4 19) chain C residue 264 type sequence H description BINDING SITE FOR RESIDUE SO4 C 1371 source : AC4 20) chain B residue 465 type sequence Q description BINDING SITE FOR RESIDUE EDO D 1480 source : AC5 21) chain C residue 334 type sequence Y description BINDING SITE FOR RESIDUE EDO D 1480 source : AC5 22) chain C residue 337 type sequence T description BINDING SITE FOR RESIDUE EDO D 1480 source : AC5 23) chain C residue 338 type sequence S description BINDING SITE FOR RESIDUE EDO D 1480 source : AC5 24) chain D residue 396 type sequence E description BINDING SITE FOR RESIDUE EDO D 1480 source : AC5 25) chain D residue 399 type sequence F description BINDING SITE FOR RESIDUE EDO D 1480 source : AC5 26) chain C residue 303 type sequence D description BINDING SITE FOR RESIDUE EDO E 1169 source : AC6 27) chain C residue 306 type sequence N description BINDING SITE FOR RESIDUE EDO E 1169 source : AC6 28) chain E residue 19 type sequence L description BINDING SITE FOR RESIDUE EDO E 1169 source : AC6 29) chain E residue 20 type sequence E description BINDING SITE FOR RESIDUE EDO E 1169 source : AC6 30) chain E residue 23 type sequence R description BINDING SITE FOR RESIDUE EDO E 1169 source : AC6 31) chain E residue 44 type sequence D description BINDING SITE FOR RESIDUE EDO E 1169 source : AC6 32) chain E residue 53 type sequence L description BINDING SITE FOR RESIDUE EDO E 1169 source : AC6 33) chain A residue 275 type sequence E description BINDING SITE FOR RESIDUE EDO F 1169 source : AC7 34) chain F residue 74 type sequence N description BINDING SITE FOR RESIDUE EDO F 1169 source : AC7 35) chain F residue 105 type sequence D description BINDING SITE FOR RESIDUE EDO F 1169 source : AC7 36) chain F residue 108 type sequence A description BINDING SITE FOR RESIDUE EDO F 1169 source : AC7 37) chain F residue 124 type sequence G description BINDING SITE FOR RESIDUE EDO F 1170 source : AC8 38) chain F residue 125 type sequence H description BINDING SITE FOR RESIDUE EDO F 1170 source : AC8 39) chain F residue 126 type sequence L description BINDING SITE FOR RESIDUE EDO F 1170 source : AC8 40) chain F residue 127 type sequence E description BINDING SITE FOR RESIDUE EDO F 1170 source : AC8 41) chain A residue 258 type catalytic sequence R description 818 source MCSA : MCSA1 42) chain A residue 317 type catalytic sequence H description 818 source MCSA : MCSA1 43) chain A residue 318 type catalytic sequence G description 818 source MCSA : MCSA1 44) chain A residue 360 type catalytic sequence C description 818 source MCSA : MCSA1 45) chain C residue 258 type catalytic sequence R description 818 source MCSA : MCSA2 46) chain C residue 317 type catalytic sequence H description 818 source MCSA : MCSA2 47) chain C residue 318 type catalytic sequence G description 818 source MCSA : MCSA2 48) chain C residue 360 type catalytic sequence C description 818 source MCSA : MCSA2 49) chain C residue 317 type SITE sequence H description Cleavage; by autocatalytic cleavage => ECO:0000269|PubMed:8962078, ECO:0000269|PubMed:9184224 source Swiss-Prot : SWS_FT_FI1 50) chain C residue 360 type SITE sequence C description Cleavage; by autocatalytic cleavage => ECO:0000269|PubMed:8962078, ECO:0000269|PubMed:9184224 source Swiss-Prot : SWS_FT_FI1 51) chain A residue 304-318 type prosite sequence HSNMDCFICCILSHG description CASPASE_HIS Caspase family histidine active site. HsnmdCfiCcILSHG source prosite : PS01121 52) chain A residue 351-362 type prosite sequence KPKVFFIQACQG description CASPASE_CYS Caspase family cysteine active site. KPKVFFIQACQG source prosite : PS01122 53) chain B residue 413 type MOD_RES sequence R description (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120 source Swiss-Prot : SWS_FT_FI4 54) chain D residue 413 type MOD_RES sequence R description (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120 source Swiss-Prot : SWS_FT_FI4

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