eF-site ID 2y1l-A PDB Code 2y1l Chain A click to enlarge Title Caspase-8 in Complex with DARPin-8.4 Classification HYDROLASE/INHIBITOR Compound CASPASE-8 Source Homo sapiens (Human) (2Y1L) Sequence A:  LDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRN GTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQL MDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFT GLKCPSLAGKPKVFFIQACQGDNYQKGIPV Description Functional site 1) chain A residue 242 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1372 source : AC1 2) chain A residue 261 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1372 source : AC1 3) chain A residue 262 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1372 source : AC1 4) chain A residue 263 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1372 source : AC1 5) chain A residue 264 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1372 source : AC1 6) chain A residue 275 type sequence E description BINDING SITE FOR RESIDUE EDO F 1169 source : AC7 7) chain A residue 258 type catalytic sequence R description 818 source MCSA : MCSA1 8) chain A residue 317 type catalytic sequence H description 818 source MCSA : MCSA1 9) chain A residue 318 type catalytic sequence G description 818 source MCSA : MCSA1 10) chain A residue 360 type catalytic sequence C description 818 source MCSA : MCSA1 11) chain A residue 304-318 type prosite sequence HSNMDCFICCILSHG description CASPASE_HIS Caspase family histidine active site. HsnmdCfiCcILSHG source prosite : PS01121 12) chain A residue 351-362 type prosite sequence KPKVFFIQACQG description CASPASE_CYS Caspase family cysteine active site. KPKVFFIQACQG source prosite : PS01122

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