eF-site ID 2y0b-ABCDGH PDB Code 2y0b Chain A, B, C, D, G, H click to enlarge Title Caspase-3 in Complex with an Inhibitory DARPin-3.4_S76R Classification HYDROLASE/PROTEIN BINDING Compound CASPASE-3 SUBUNIT P17 Source (2Y0B) Sequence A:  DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAAN LRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSS FVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTG KPKLFIIQAXRGTELDCGIET B:  CHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAML KQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIP CIVSMLTKELYFYH C:  DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAAN LRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSS FVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTG KPKLFIIQAXRGTELDCGIET D:  HKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLK QYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPC IVSMLTKELYFYH G:  DLGKKLLEATRAGQDDEVRILMANGADVNAMDDAGVTPLH LAAKRGHLEIVEVLLKHGADVNARDIWGRTPLHLAATVGH LEIVEVLLEYGADVNAQDKFGKTAFDISIDNGNEDLAEI H:  DLGKKLLEATRAGQDDEVRILMANGADVNAMDDAGVTPLH LAAKRGHLEIVEVLLKHGADVNARDIWGRTPLHLAATVGH LEIVEVLLEYGADVNAQDKFGKTAFDISIDNGNEDLAEIL Description Functional site 1) chain A residue 88 type sequence K description BINDING SITE FOR RESIDUE MPD A 1175 source : AC1 2) chain A residue 89 type sequence N description BINDING SITE FOR RESIDUE MPD A 1175 source : AC1 3) chain A residue 90 type sequence D description BINDING SITE FOR RESIDUE MPD A 1175 source : AC1 4) chain A residue 91 type sequence L description BINDING SITE FOR RESIDUE MPD A 1175 source : AC1 5) chain A residue 65 type sequence S description BINDING SITE FOR RESIDUE MPD B 1278 source : AC2 6) chain B residue 207 type sequence R description BINDING SITE FOR RESIDUE MPD B 1278 source : AC2 7) chain B residue 209 type sequence S description BINDING SITE FOR RESIDUE MPD B 1278 source : AC2 8) chain G residue 78 type sequence I description BINDING SITE FOR RESIDUE MPD B 1278 source : AC2 9) chain C residue 71 type sequence A description BINDING SITE FOR RESIDUE MRD C 1175 source : AC3 10) chain C residue 87 type sequence N description BINDING SITE FOR RESIDUE MRD C 1175 source : AC3 11) chain C residue 89 type sequence N description BINDING SITE FOR RESIDUE MRD C 1175 source : AC3 12) chain A residue 51 type sequence N description BINDING SITE FOR RESIDUE MRD A 1176 source : AC4 13) chain A residue 68 type sequence D description BINDING SITE FOR RESIDUE MRD A 1176 source : AC4 14) chain A residue 71 type sequence A description BINDING SITE FOR RESIDUE MRD A 1176 source : AC4 15) chain A residue 87 type sequence N description BINDING SITE FOR RESIDUE MRD A 1176 source : AC4 16) chain A residue 89 type sequence N description BINDING SITE FOR RESIDUE MRD A 1176 source : AC4 17) chain A residue 163 type MOD_RES sequence X description S-nitrosocysteine; in inhibited form => ECO:0000269|PubMed:10213689 source Swiss-Prot : SWS_FT_FI2 18) chain C residue 163 type MOD_RES sequence X description S-nitrosocysteine; in inhibited form => ECO:0000269|PubMed:10213689 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 62 type catalytic sequence T description 815 source MCSA : MCSA1 20) chain A residue 63 type catalytic sequence S description 815 source MCSA : MCSA1 21) chain A residue 121 type catalytic sequence H description 815 source MCSA : MCSA1 22) chain A residue 122 type catalytic sequence G description 815 source MCSA : MCSA1 23) chain A residue 163 type catalytic sequence X description 815 source MCSA : MCSA1 24) chain C residue 62 type catalytic sequence T description 815 source MCSA : MCSA2 25) chain C residue 63 type catalytic sequence S description 815 source MCSA : MCSA2 26) chain C residue 121 type catalytic sequence H description 815 source MCSA : MCSA2 27) chain C residue 122 type catalytic sequence G description 815 source MCSA : MCSA2 28) chain C residue 163 type catalytic sequence X description 815 source MCSA : MCSA2 29) chain B residue 207 type MOD_RES sequence R description (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 207 type MOD_RES sequence R description (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631 source Swiss-Prot : SWS_FT_FI1 31) chain C residue 121 type MOD_RES sequence H description (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631 source Swiss-Prot : SWS_FT_FI1 32) chain C residue 163 type MOD_RES sequence X description (Microbial infection) ADP-riboxanated arginine => ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 108-122 type prosite sequence HSKRSSFVCVLLSHG description CASPASE_HIS Caspase family histidine active site. HskrsSfvCvLLSHG source prosite : PS01121 34) chain A residue 154-165 type prosite sequence KPKLFIIQAXRG description CASPASE_CYS Caspase family cysteine active site. KPKLFIIQACRG source prosite : PS01122

Display surface Download Links