eF-site ID 2y02-AB PDB Code 2y02 Chain A, B click to enlarge Title TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST CARMOTEROL Classification RECEPTOR Compound BETA-1 ADRENERGIC RECEPTOR Source (ADRB1_MELGA) Sequence A:  AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRL QTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSF LCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC YQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYR EAKEQSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIV NVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKA FKRLLA B:  AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRL QTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSF LCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC YQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYR EAKEQIRKIDRASKRKTSRVMLMREHKALKTLGIIMGVFT LCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNP IIYCRSPDFRKAFKRLLA Description Functional site 1) chain A residue 192 type sequence C description BINDING SITE FOR RESIDUE NA A 701 source : AC1 2) chain A residue 193 type sequence Y description BINDING SITE FOR RESIDUE NA A 701 source : AC1 3) chain A residue 195 type sequence D description BINDING SITE FOR RESIDUE NA A 701 source : AC1 4) chain A residue 198 type sequence C description BINDING SITE FOR RESIDUE NA A 701 source : AC1 5) chain A residue 130 type sequence E description BINDING SITE FOR RESIDUE Y01 A 401 source : AC2 6) chain A residue 157 type sequence R description BINDING SITE FOR RESIDUE Y01 A 401 source : AC2 7) chain A residue 160 type sequence V description BINDING SITE FOR RESIDUE Y01 A 401 source : AC2 8) chain A residue 161 type sequence I description BINDING SITE FOR RESIDUE Y01 A 401 source : AC2 9) chain A residue 164 type sequence T description BINDING SITE FOR RESIDUE Y01 A 401 source : AC2 10) chain A residue 214 type sequence I description BINDING SITE FOR RESIDUE Y01 A 401 source : AC2 11) chain B residue 205 type sequence R description BINDING SITE FOR RESIDUE Y01 A 401 source : AC2 12) chain B residue 206 type sequence A description BINDING SITE FOR RESIDUE Y01 A 401 source : AC2 13) chain B residue 210 type sequence A description BINDING SITE FOR RESIDUE Y01 A 401 source : AC2 14) chain A residue 73 type sequence Q description BINDING SITE FOR RESIDUE Y01 A 402 source : AC3 15) chain A residue 85 type sequence C description BINDING SITE FOR RESIDUE Y01 A 402 source : AC3 16) chain A residue 155 type sequence R description BINDING SITE FOR RESIDUE Y01 A 402 source : AC3 17) chain A residue 159 type sequence K description BINDING SITE FOR RESIDUE Y01 A 402 source : AC3 18) chain A residue 166 type sequence W description BINDING SITE FOR RESIDUE Y01 A 402 source : AC3 19) chain A residue 181 type sequence W description BINDING SITE FOR RESIDUE 2CV A 501 source : AC4 20) chain A residue 184 type sequence D description BINDING SITE FOR RESIDUE 2CV A 501 source : AC4 21) chain A residue 185 type sequence E description BINDING SITE FOR RESIDUE 2CV A 501 source : AC4 22) chain A residue 204 type sequence N description BINDING SITE FOR RESIDUE 2CV A 501 source : AC4 23) chain A residue 206 type sequence A description BINDING SITE FOR RESIDUE 2CV A 501 source : AC4 24) chain B residue 160 type sequence V description BINDING SITE FOR RESIDUE 2CV A 501 source : AC4 25) chain B residue 164 type sequence T description BINDING SITE FOR RESIDUE 2CV A 501 source : AC4 26) chain A residue 227 type sequence A description BINDING SITE FOR RESIDUE 2CV A 502 source : AC5 27) chain A residue 289 type sequence L description BINDING SITE FOR RESIDUE 2CV A 502 source : AC5 28) chain A residue 205 type sequence R description BINDING SITE FOR RESIDUE 2CV A 503 source : AC6 29) chain A residue 315 type sequence F description BINDING SITE FOR RESIDUE 2CV A 503 source : AC6 30) chain B residue 148 type sequence R description BINDING SITE FOR RESIDUE 2CV A 503 source : AC6 31) chain B residue 157 type sequence R description BINDING SITE FOR RESIDUE 2CV A 503 source : AC6 32) chain A residue 51 type sequence V description BINDING SITE FOR RESIDUE 2CV A 504 source : AC7 33) chain A residue 326 type sequence V description BINDING SITE FOR RESIDUE 2CV A 504 source : AC7 34) chain A residue 334 type sequence A description BINDING SITE FOR RESIDUE 2CV A 504 source : AC7 35) chain A residue 338 type sequence M description BINDING SITE FOR RESIDUE 2CV A 504 source : AC7 36) chain A residue 160 type sequence V description BINDING SITE FOR RESIDUE 2CV A 505 source : AC8 37) chain A residue 163 type sequence C description BINDING SITE FOR RESIDUE 2CV A 505 source : AC8 38) chain B residue 185 type sequence E description BINDING SITE FOR RESIDUE 2CV A 505 source : AC8 39) chain A residue 117 type sequence W description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 40) chain A residue 121 type sequence D description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 41) chain A residue 200 type sequence D description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 42) chain A residue 201 type sequence F description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 43) chain A residue 208 type sequence A description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 44) chain A residue 211 type sequence S description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 45) chain A residue 215 type sequence S description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 46) chain A residue 306 type sequence F description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 47) chain A residue 307 type sequence F description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 48) chain A residue 310 type sequence N description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 49) chain A residue 325 type sequence F description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 50) chain A residue 326 type sequence V description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 51) chain A residue 329 type sequence N description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 52) chain A residue 333 type sequence Y description BINDING SITE FOR RESIDUE WHJ A 601 source : AC9 53) chain A residue 205 type sequence R description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 54) chain A residue 206 type sequence A description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 55) chain A residue 209 type sequence I description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 56) chain B residue 130 type sequence E description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 57) chain B residue 157 type sequence R description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 58) chain B residue 160 type sequence V description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 59) chain B residue 161 type sequence I description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 60) chain B residue 78 type sequence L description BINDING SITE FOR RESIDUE Y01 B 402 source : BC2 61) chain B residue 85 type sequence C description BINDING SITE FOR RESIDUE Y01 B 402 source : BC2 62) chain B residue 155 type sequence R description BINDING SITE FOR RESIDUE Y01 B 402 source : BC2 63) chain B residue 159 type sequence K description BINDING SITE FOR RESIDUE Y01 B 402 source : BC2 64) chain B residue 166 type sequence W description BINDING SITE FOR RESIDUE Y01 B 402 source : BC2 65) chain A residue 160 type sequence V description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 66) chain A residue 164 type sequence T description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 67) chain B residue 180 type sequence H description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 68) chain B residue 181 type sequence W description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 69) chain B residue 183 type sequence R description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 70) chain B residue 184 type sequence D description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 71) chain B residue 185 type sequence E description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 72) chain B residue 204 type sequence N description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 73) chain B residue 238 type sequence I description BINDING SITE FOR RESIDUE 2CV B 502 source : BC4 74) chain B residue 286 type sequence H description BINDING SITE FOR RESIDUE 2CV B 502 source : BC4 75) chain B residue 296 type sequence M description BINDING SITE FOR RESIDUE 2CV B 502 source : BC4 76) chain A residue 157 type sequence R description BINDING SITE FOR RESIDUE 2CV B 503 source : BC5 77) chain B residue 205 type sequence R description BINDING SITE FOR RESIDUE 2CV B 503 source : BC5 78) chain B residue 47 type sequence L description BINDING SITE FOR RESIDUE 2CV B 504 source : BC6 79) chain A residue 185 type sequence E description BINDING SITE FOR RESIDUE 2CV B 505 source : BC7 80) chain B residue 160 type sequence V description BINDING SITE FOR RESIDUE 2CV B 505 source : BC7 81) chain B residue 163 type sequence C description BINDING SITE FOR RESIDUE 2CV B 505 source : BC7 82) chain B residue 166 type sequence W description BINDING SITE FOR RESIDUE 2CV B 505 source : BC7 83) chain B residue 117 type sequence W description BINDING SITE FOR RESIDUE WHJ B 601 source : BC8 84) chain B residue 121 type sequence D description BINDING SITE FOR RESIDUE WHJ B 601 source : BC8 85) chain B residue 125 type sequence V description BINDING SITE FOR RESIDUE WHJ B 601 source : BC8 86) chain B residue 199 type sequence C description BINDING SITE FOR RESIDUE WHJ B 601 source : BC8 87) chain B residue 200 type sequence D description BINDING SITE FOR RESIDUE WHJ B 601 source : BC8 88) chain B residue 208 type sequence A description BINDING SITE FOR RESIDUE WHJ B 601 source : BC8 89) chain B residue 211 type sequence S description BINDING SITE FOR RESIDUE WHJ B 601 source : BC8 90) chain B residue 215 type sequence S description BINDING SITE FOR RESIDUE WHJ B 601 source : BC8 91) chain B residue 306 type sequence F description BINDING SITE FOR RESIDUE WHJ B 601 source : BC8 92) chain B residue 310 type sequence N description BINDING SITE FOR RESIDUE WHJ B 601 source : BC8 93) chain B residue 329 type sequence N description BINDING SITE FOR RESIDUE WHJ B 601 source : BC8 94) chain B residue 333 type sequence Y description BINDING SITE FOR RESIDUE WHJ B 601 source : BC8 95) chain A residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 96) chain A residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 97) chain A residue 232-313 type TOPO_DOM sequence REAKEQSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNI VN description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 98) chain B residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 99) chain B residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 100) chain B residue 232-313 type TOPO_DOM sequence REAKEQIRKIDRASKRKTSRVMLMREHKALKTLGIIMGVF TLCWLPFFLVNIVN description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 101) chain A residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 102) chain A residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 103) chain A residue 344-348 type TOPO_DOM sequence CRSPD description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 104) chain B residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 105) chain B residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 106) chain B residue 344-348 type TOPO_DOM sequence CRSPD description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 107) chain A residue 127-143 type prosite sequence ASIETLCVIAIDRYLAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAIDRYLaI source prosite : PS00237 108) chain A residue 39-67 type TRANSMEM sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 109) chain B residue 39-67 type TRANSMEM sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 110) chain A residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 111) chain B residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 112) chain A residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASIETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 113) chain B residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASIETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 114) chain A residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 115) chain B residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 116) chain A residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 117) chain B residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 118) chain A residue 314-343 type TRANSMEM sequence VFNRDLVPDWLFVAFNWLGYANSAMNPIIY description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 119) chain B residue 314-343 type TRANSMEM sequence VFNRDLVPDWLFVAFNWLGYANSAMNPIIY description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 120) chain A residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 121) chain A residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 122) chain A residue 357 type BINDING sequence L description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 123) chain B residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 124) chain B residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 125) chain B residue 357 type BINDING sequence L description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10

Display surface Download Links