eF-site ID 2y01-AB PDB Code 2y01 Chain A, B click to enlarge Title TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB102) Classification RECEPTOR Compound BETA-1 ADRENERGIC RECEPTOR Source (ADRB1_MELGA) Sequence A:  AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRL QTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSF LCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC YQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYR EAKEQSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIV NVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKA FKRLLA B:  AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRL QTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSF LCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC YQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYR EAKEQIRKIDRASKRKTSRVMLMREHKALKTLGIIMGVFT LCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNP IIYCRSPDFRKAFKRLLA Description Functional site 1) chain A residue 157 type sequence R description BINDING SITE FOR RESIDUE Y01 A 401 source : AC1 2) chain A residue 161 type sequence I description BINDING SITE FOR RESIDUE Y01 A 401 source : AC1 3) chain B residue 205 type sequence R description BINDING SITE FOR RESIDUE Y01 A 401 source : AC1 4) chain B residue 206 type sequence A description BINDING SITE FOR RESIDUE Y01 A 401 source : AC1 5) chain A residue 67 type sequence G description BINDING SITE FOR RESIDUE Y01 A 402 source : AC2 6) chain A residue 78 type sequence L description BINDING SITE FOR RESIDUE Y01 A 402 source : AC2 7) chain A residue 166 type sequence W description BINDING SITE FOR RESIDUE Y01 A 402 source : AC2 8) chain A residue 180 type sequence H description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 9) chain A residue 181 type sequence W description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 10) chain A residue 183 type sequence R description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 11) chain A residue 184 type sequence D description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 12) chain A residue 204 type sequence N description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 13) chain B residue 160 type sequence V description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 14) chain B residue 164 type sequence T description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 15) chain A residue 289 type sequence L description BINDING SITE FOR RESIDUE 2CV A 502 source : AC4 16) chain A residue 205 type sequence R description BINDING SITE FOR RESIDUE 2CV A 503 source : AC5 17) chain A residue 314 type sequence V description BINDING SITE FOR RESIDUE 2CV A 503 source : AC5 18) chain A residue 315 type sequence F description BINDING SITE FOR RESIDUE 2CV A 503 source : AC5 19) chain B residue 152 type sequence L description BINDING SITE FOR RESIDUE 2CV A 503 source : AC5 20) chain B residue 157 type sequence R description BINDING SITE FOR RESIDUE 2CV A 503 source : AC5 21) chain A residue 51 type sequence V description BINDING SITE FOR RESIDUE 2CV A 504 source : AC6 22) chain A residue 326 type sequence V description BINDING SITE FOR RESIDUE 2CV A 504 source : AC6 23) chain A residue 338 type sequence M description BINDING SITE FOR RESIDUE 2CV A 504 source : AC6 24) chain A residue 159 type sequence K description BINDING SITE FOR RESIDUE 2CV A 505 source : AC7 25) chain A residue 160 type sequence V description BINDING SITE FOR RESIDUE 2CV A 505 source : AC7 26) chain A residue 163 type sequence C description BINDING SITE FOR RESIDUE 2CV A 505 source : AC7 27) chain B residue 185 type sequence E description BINDING SITE FOR RESIDUE 2CV A 505 source : AC7 28) chain A residue 121 type sequence D description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 29) chain A residue 211 type sequence S description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 30) chain A residue 306 type sequence F description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 31) chain A residue 307 type sequence F description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 32) chain A residue 310 type sequence N description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 33) chain A residue 329 type sequence N description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 34) chain A residue 330 type sequence W description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 35) chain A residue 333 type sequence Y description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 36) chain A residue 206 type sequence A description BINDING SITE FOR RESIDUE Y01 B 401 source : AC9 37) chain B residue 133 type sequence C description BINDING SITE FOR RESIDUE Y01 B 401 source : AC9 38) chain B residue 157 type sequence R description BINDING SITE FOR RESIDUE Y01 B 401 source : AC9 39) chain B residue 160 type sequence V description BINDING SITE FOR RESIDUE Y01 B 401 source : AC9 40) chain B residue 214 type sequence I description BINDING SITE FOR RESIDUE Y01 B 401 source : AC9 41) chain B residue 78 type sequence L description BINDING SITE FOR RESIDUE Y01 B 402 source : BC1 42) chain B residue 159 type sequence K description BINDING SITE FOR RESIDUE Y01 B 402 source : BC1 43) chain B residue 166 type sequence W description BINDING SITE FOR RESIDUE Y01 B 402 source : BC1 44) chain A residue 160 type sequence V description BINDING SITE FOR RESIDUE 2CV B 501 source : BC2 45) chain A residue 164 type sequence T description BINDING SITE FOR RESIDUE 2CV B 501 source : BC2 46) chain B residue 176 type sequence P description BINDING SITE FOR RESIDUE 2CV B 501 source : BC2 47) chain B residue 181 type sequence W description BINDING SITE FOR RESIDUE 2CV B 501 source : BC2 48) chain B residue 184 type sequence D description BINDING SITE FOR RESIDUE 2CV B 501 source : BC2 49) chain B residue 185 type sequence E description BINDING SITE FOR RESIDUE 2CV B 501 source : BC2 50) chain B residue 231 type sequence Y description BINDING SITE FOR RESIDUE 2CV B 502 source : BC3 51) chain B residue 286 type sequence H description BINDING SITE FOR RESIDUE 2CV B 502 source : BC3 52) chain B residue 289 type sequence L description BINDING SITE FOR RESIDUE 2CV B 502 source : BC3 53) chain B residue 293 type sequence G description BINDING SITE FOR RESIDUE 2CV B 502 source : BC3 54) chain A residue 157 type sequence R description BINDING SITE FOR RESIDUE 2CV B 503 source : BC4 55) chain B residue 315 type sequence F description BINDING SITE FOR RESIDUE 2CV B 503 source : BC4 56) chain B residue 48 type sequence M description BINDING SITE FOR RESIDUE 2CV B 504 source : BC5 57) chain B residue 330 type sequence W description BINDING SITE FOR RESIDUE 2CV B 504 source : BC5 58) chain A residue 185 type sequence E description BINDING SITE FOR RESIDUE 2CV B 505 source : BC6 59) chain B residue 159 type sequence K description BINDING SITE FOR RESIDUE 2CV B 505 source : BC6 60) chain B residue 160 type sequence V description BINDING SITE FOR RESIDUE 2CV B 505 source : BC6 61) chain B residue 163 type sequence C description BINDING SITE FOR RESIDUE 2CV B 505 source : BC6 62) chain B residue 166 type sequence W description BINDING SITE FOR RESIDUE 2CV B 505 source : BC6 63) chain B residue 102 type sequence V description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 64) chain B residue 117 type sequence W description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 65) chain B residue 118 type sequence T description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 66) chain B residue 121 type sequence D description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 67) chain B residue 201 type sequence F description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 68) chain B residue 211 type sequence S description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 69) chain B residue 310 type sequence N description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 70) chain B residue 329 type sequence N description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 71) chain B residue 330 type sequence W description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 72) chain B residue 333 type sequence Y description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 73) chain A residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 74) chain A residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 75) chain A residue 232-313 type TOPO_DOM sequence REAKEQSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNI VN description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 76) chain B residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 77) chain B residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 78) chain B residue 232-313 type TOPO_DOM sequence REAKEQIRKIDRASKRKTSRVMLMREHKALKTLGIIMGVF TLCWLPFFLVNIVN description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 79) chain A residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 80) chain A residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 81) chain A residue 344-348 type TOPO_DOM sequence CRSPD description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 82) chain B residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 83) chain B residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 84) chain B residue 344-348 type TOPO_DOM sequence CRSPD description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 85) chain A residue 127-143 type prosite sequence ASIETLCVIAIDRYLAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAIDRYLaI source prosite : PS00237 86) chain A residue 39-67 type TRANSMEM sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 87) chain B residue 39-67 type TRANSMEM sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 88) chain A residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 89) chain B residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 90) chain A residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASIETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 91) chain B residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASIETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 92) chain A residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 93) chain B residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 94) chain A residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 95) chain B residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 96) chain A residue 314-343 type TRANSMEM sequence VFNRDLVPDWLFVAFNWLGYANSAMNPIIY description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 97) chain B residue 314-343 type TRANSMEM sequence VFNRDLVPDWLFVAFNWLGYANSAMNPIIY description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 98) chain A residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 99) chain A residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 100) chain A residue 357 type BINDING sequence L description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 101) chain B residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 102) chain B residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 103) chain B residue 357 type BINDING sequence L description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10

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