eF-site ID 2y01-A PDB Code 2y01 Chain A click to enlarge Title TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB102) Classification RECEPTOR Compound BETA-1 ADRENERGIC RECEPTOR Source (ADRB1_MELGA) Sequence A:  AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRL QTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSF LCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC YQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYR EAKEQSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIV NVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKA FKRLLA Description Functional site 1) chain A residue 157 type sequence R description BINDING SITE FOR RESIDUE Y01 A 401 source : AC1 2) chain A residue 161 type sequence I description BINDING SITE FOR RESIDUE Y01 A 401 source : AC1 3) chain A residue 67 type sequence G description BINDING SITE FOR RESIDUE Y01 A 402 source : AC2 4) chain A residue 78 type sequence L description BINDING SITE FOR RESIDUE Y01 A 402 source : AC2 5) chain A residue 166 type sequence W description BINDING SITE FOR RESIDUE Y01 A 402 source : AC2 6) chain A residue 180 type sequence H description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 7) chain A residue 181 type sequence W description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 8) chain A residue 183 type sequence R description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 9) chain A residue 184 type sequence D description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 10) chain A residue 204 type sequence N description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 11) chain A residue 289 type sequence L description BINDING SITE FOR RESIDUE 2CV A 502 source : AC4 12) chain A residue 205 type sequence R description BINDING SITE FOR RESIDUE 2CV A 503 source : AC5 13) chain A residue 314 type sequence V description BINDING SITE FOR RESIDUE 2CV A 503 source : AC5 14) chain A residue 315 type sequence F description BINDING SITE FOR RESIDUE 2CV A 503 source : AC5 15) chain A residue 51 type sequence V description BINDING SITE FOR RESIDUE 2CV A 504 source : AC6 16) chain A residue 326 type sequence V description BINDING SITE FOR RESIDUE 2CV A 504 source : AC6 17) chain A residue 338 type sequence M description BINDING SITE FOR RESIDUE 2CV A 504 source : AC6 18) chain A residue 159 type sequence K description BINDING SITE FOR RESIDUE 2CV A 505 source : AC7 19) chain A residue 160 type sequence V description BINDING SITE FOR RESIDUE 2CV A 505 source : AC7 20) chain A residue 163 type sequence C description BINDING SITE FOR RESIDUE 2CV A 505 source : AC7 21) chain A residue 121 type sequence D description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 22) chain A residue 211 type sequence S description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 23) chain A residue 306 type sequence F description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 24) chain A residue 307 type sequence F description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 25) chain A residue 310 type sequence N description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 26) chain A residue 329 type sequence N description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 27) chain A residue 330 type sequence W description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 28) chain A residue 333 type sequence Y description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 29) chain A residue 206 type sequence A description BINDING SITE FOR RESIDUE Y01 B 401 source : AC9 30) chain A residue 160 type sequence V description BINDING SITE FOR RESIDUE 2CV B 501 source : BC2 31) chain A residue 164 type sequence T description BINDING SITE FOR RESIDUE 2CV B 501 source : BC2 32) chain A residue 157 type sequence R description BINDING SITE FOR RESIDUE 2CV B 503 source : BC4 33) chain A residue 185 type sequence E description BINDING SITE FOR RESIDUE 2CV B 505 source : BC6 34) chain A residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 232-313 type TOPO_DOM sequence REAKEQSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNI VN description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 38) chain A residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 39) chain A residue 344-348 type TOPO_DOM sequence CRSPD description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 40) chain A residue 127-143 type prosite sequence ASIETLCVIAIDRYLAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAIDRYLaI source prosite : PS00237 41) chain A residue 39-67 type TRANSMEM sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 43) chain A residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASIETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 44) chain A residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 45) chain A residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 46) chain A residue 314-343 type TRANSMEM sequence VFNRDLVPDWLFVAFNWLGYANSAMNPIIY description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 47) chain A residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 48) chain A residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 49) chain A residue 357 type BINDING sequence L description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10

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