eF-site ID 2y00-AB PDB Code 2y00 Chain A, B click to enlarge Title TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB92) Classification RECEPTOR Compound BETA-1 ADRENERGIC RECEPTOR Source (ADRB1_MELGA) Sequence A:  AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRL QTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSF LCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC YQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYR EAKEQSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIV NVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKA FKRLLA B:  AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRL QTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSF LCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC YQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYR EAKEQIRKIDRASKRKTSRVMLMREHKALKTLGIIMGVFT LCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNP IIYCRSPDFRKAFKRLLA Description Functional site 1) chain A residue 133 type sequence C description BINDING SITE FOR RESIDUE Y01 A 401 source : AC1 2) chain A residue 157 type sequence R description BINDING SITE FOR RESIDUE Y01 A 401 source : AC1 3) chain A residue 161 type sequence I description BINDING SITE FOR RESIDUE Y01 A 401 source : AC1 4) chain B residue 205 type sequence R description BINDING SITE FOR RESIDUE Y01 A 401 source : AC1 5) chain B residue 206 type sequence A description BINDING SITE FOR RESIDUE Y01 A 401 source : AC1 6) chain B residue 209 type sequence I description BINDING SITE FOR RESIDUE Y01 A 401 source : AC1 7) chain A residue 78 type sequence L description BINDING SITE FOR RESIDUE Y01 A 402 source : AC2 8) chain A residue 85 type sequence C description BINDING SITE FOR RESIDUE Y01 A 402 source : AC2 9) chain A residue 155 type sequence R description BINDING SITE FOR RESIDUE Y01 A 402 source : AC2 10) chain A residue 166 type sequence W description BINDING SITE FOR RESIDUE Y01 A 402 source : AC2 11) chain A residue 180 type sequence H description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 12) chain A residue 181 type sequence W description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 13) chain A residue 184 type sequence D description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 14) chain A residue 185 type sequence E description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 15) chain A residue 204 type sequence N description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 16) chain B residue 160 type sequence V description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 17) chain B residue 164 type sequence T description BINDING SITE FOR RESIDUE 2CV A 501 source : AC3 18) chain A residue 289 type sequence L description BINDING SITE FOR RESIDUE 2CV A 502 source : AC4 19) chain A residue 205 type sequence R description BINDING SITE FOR RESIDUE 2CV A 503 source : AC5 20) chain A residue 315 type sequence F description BINDING SITE FOR RESIDUE 2CV A 503 source : AC5 21) chain B residue 148 type sequence R description BINDING SITE FOR RESIDUE 2CV A 503 source : AC5 22) chain B residue 152 type sequence L description BINDING SITE FOR RESIDUE 2CV A 503 source : AC5 23) chain B residue 157 type sequence R description BINDING SITE FOR RESIDUE 2CV A 503 source : AC5 24) chain A residue 51 type sequence V description BINDING SITE FOR RESIDUE 2CV A 504 source : AC6 25) chain A residue 334 type sequence A description BINDING SITE FOR RESIDUE 2CV A 504 source : AC6 26) chain A residue 163 type sequence C description BINDING SITE FOR RESIDUE 2CV A 505 source : AC7 27) chain B residue 181 type sequence W description BINDING SITE FOR RESIDUE 2CV A 505 source : AC7 28) chain A residue 101 type sequence L description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 29) chain A residue 102 type sequence V description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 30) chain A residue 117 type sequence W description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 31) chain A residue 121 type sequence D description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 32) chain A residue 201 type sequence F description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 33) chain A residue 211 type sequence S description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 34) chain A residue 306 type sequence F description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 35) chain A residue 310 type sequence N description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 36) chain A residue 329 type sequence N description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 37) chain A residue 330 type sequence W description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 38) chain A residue 333 type sequence Y description BINDING SITE FOR RESIDUE Y00 A 601 source : AC8 39) chain A residue 192 type sequence C description BINDING SITE FOR RESIDUE NA A 1359 source : AC9 40) chain A residue 195 type sequence D description BINDING SITE FOR RESIDUE NA A 1359 source : AC9 41) chain A residue 198 type sequence C description BINDING SITE FOR RESIDUE NA A 1359 source : AC9 42) chain A residue 205 type sequence R description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 43) chain A residue 206 type sequence A description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 44) chain A residue 209 type sequence I description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 45) chain B residue 130 type sequence E description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 46) chain B residue 133 type sequence C description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 47) chain B residue 157 type sequence R description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 48) chain B residue 160 type sequence V description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 49) chain B residue 161 type sequence I description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 50) chain B residue 164 type sequence T description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 51) chain B residue 168 type sequence I description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 52) chain B residue 214 type sequence I description BINDING SITE FOR RESIDUE Y01 B 401 source : BC1 53) chain B residue 78 type sequence L description BINDING SITE FOR RESIDUE Y01 B 402 source : BC2 54) chain B residue 155 type sequence R description BINDING SITE FOR RESIDUE Y01 B 402 source : BC2 55) chain B residue 159 type sequence K description BINDING SITE FOR RESIDUE Y01 B 402 source : BC2 56) chain B residue 166 type sequence W description BINDING SITE FOR RESIDUE Y01 B 402 source : BC2 57) chain A residue 160 type sequence V description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 58) chain A residue 164 type sequence T description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 59) chain B residue 180 type sequence H description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 60) chain B residue 181 type sequence W description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 61) chain B residue 183 type sequence R description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 62) chain B residue 184 type sequence D description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 63) chain B residue 185 type sequence E description BINDING SITE FOR RESIDUE 2CV B 501 source : BC3 64) chain B residue 231 type sequence Y description BINDING SITE FOR RESIDUE 2CV B 502 source : BC4 65) chain B residue 286 type sequence H description BINDING SITE FOR RESIDUE 2CV B 502 source : BC4 66) chain B residue 289 type sequence L description BINDING SITE FOR RESIDUE 2CV B 502 source : BC4 67) chain A residue 157 type sequence R description BINDING SITE FOR RESIDUE 2CV B 503 source : BC5 68) chain B residue 205 type sequence R description BINDING SITE FOR RESIDUE 2CV B 503 source : BC5 69) chain B residue 315 type sequence F description BINDING SITE FOR RESIDUE 2CV B 503 source : BC5 70) chain A residue 185 type sequence E description BINDING SITE FOR RESIDUE 2CV B 505 source : BC6 71) chain B residue 163 type sequence C description BINDING SITE FOR RESIDUE 2CV B 505 source : BC6 72) chain B residue 102 type sequence V description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 73) chain B residue 117 type sequence W description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 74) chain B residue 121 type sequence D description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 75) chain B residue 125 type sequence V description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 76) chain B residue 211 type sequence S description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 77) chain B residue 307 type sequence F description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 78) chain B residue 310 type sequence N description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 79) chain B residue 329 type sequence N description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 80) chain B residue 330 type sequence W description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 81) chain B residue 333 type sequence Y description BINDING SITE FOR RESIDUE Y00 B 601 source : BC7 82) chain A residue 127-143 type prosite sequence ASIETLCVIAIDRYLAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAIDRYLaI source prosite : PS00237 83) chain A residue 39-67 type TRANSMEM sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 84) chain B residue 39-67 type TRANSMEM sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 85) chain A residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 86) chain A residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 87) chain A residue 357 type BINDING sequence L description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 88) chain B residue 121 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 89) chain B residue 211 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 90) chain B residue 357 type BINDING sequence L description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4 source Swiss-Prot : SWS_FT_FI10 91) chain A residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 92) chain A residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 93) chain A residue 232-313 type TOPO_DOM sequence REAKEQSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNI VN description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 94) chain B residue 68-76 type TOPO_DOM sequence STQRLQTLT description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 95) chain B residue 138-155 type TOPO_DOM sequence DRYLAITSPFRYQSLMTR description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 96) chain B residue 232-313 type TOPO_DOM sequence REAKEQIRKIDRASKRKTSRVMLMREHKALKTLGIIMGVF TLCWLPFFLVNIVN description Cytoplasmic => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI2 97) chain A residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 98) chain B residue 77-103 type TRANSMEM sequence NLFITSLACADLVVGLLVVPFGATLVV description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 99) chain A residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 100) chain A residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 101) chain A residue 344-348 type TOPO_DOM sequence CRSPD description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 102) chain B residue 104-115 type TOPO_DOM sequence RGTWLWGSFLCE description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 103) chain B residue 180-205 type TOPO_DOM sequence HWWRDEDPQALKCYQDPGCCDFVTNR description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 104) chain B residue 344-348 type TOPO_DOM sequence CRSPD description Extracellular => ECO:0000269|PubMed:18594507 source Swiss-Prot : SWS_FT_FI4 105) chain A residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASIETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 106) chain B residue 116-137 type TRANSMEM sequence LWTSLDVLCVTASIETLCVIAI description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 107) chain A residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 108) chain B residue 156-179 type TRANSMEM sequence ARAKVIICTVWAISALVSFLPIMM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 109) chain A residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 110) chain B residue 206-231 type TRANSMEM sequence AYAIASSIISFYIPLLIMIFVALRVY description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 111) chain A residue 314-343 type TRANSMEM sequence VFNRDLVPDWLFVAFNWLGYANSAMNPIIY description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 112) chain B residue 314-343 type TRANSMEM sequence VFNRDLVPDWLFVAFNWLGYANSAMNPIIY description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8

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