eF-site ID 2y00-AB
PDB Code 2y00
Chain A, B

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Title TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB92)
Classification RECEPTOR
Compound BETA-1 ADRENERGIC RECEPTOR
Source (ADRB1_MELGA)
Sequence A:  AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRL
QTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSF
LCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL
MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC
YQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYR
EAKEQSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIV
NVFNRDLVPDWLFVAFNWLGYANSAMNPIIYCRSPDFRKA
FKRLLA
B:  AELLSQQWEAGMSLLMALVVLLIVAGNVLVIAAIGSTQRL
QTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSF
LCELWTSLDVLCVTASIETLCVIAIDRYLAITSPFRYQSL
MTRARAKVIICTVWAISALVSFLPIMMHWWRDEDPQALKC
YQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVALRVYR
EAKEQIRKIDRASKRKTSRVMLMREHKALKTLGIIMGVFT
LCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNP
IIYCRSPDFRKAFKRLLA
Description


Functional site

1) chain A
residue 133
type
sequence C
description BINDING SITE FOR RESIDUE Y01 A 401
source : AC1

2) chain A
residue 157
type
sequence R
description BINDING SITE FOR RESIDUE Y01 A 401
source : AC1

3) chain A
residue 161
type
sequence I
description BINDING SITE FOR RESIDUE Y01 A 401
source : AC1

4) chain B
residue 205
type
sequence R
description BINDING SITE FOR RESIDUE Y01 A 401
source : AC1

5) chain B
residue 206
type
sequence A
description BINDING SITE FOR RESIDUE Y01 A 401
source : AC1

6) chain B
residue 209
type
sequence I
description BINDING SITE FOR RESIDUE Y01 A 401
source : AC1

7) chain A
residue 78
type
sequence L
description BINDING SITE FOR RESIDUE Y01 A 402
source : AC2

8) chain A
residue 85
type
sequence C
description BINDING SITE FOR RESIDUE Y01 A 402
source : AC2

9) chain A
residue 155
type
sequence R
description BINDING SITE FOR RESIDUE Y01 A 402
source : AC2

10) chain A
residue 166
type
sequence W
description BINDING SITE FOR RESIDUE Y01 A 402
source : AC2

11) chain A
residue 180
type
sequence H
description BINDING SITE FOR RESIDUE 2CV A 501
source : AC3

12) chain A
residue 181
type
sequence W
description BINDING SITE FOR RESIDUE 2CV A 501
source : AC3

13) chain A
residue 184
type
sequence D
description BINDING SITE FOR RESIDUE 2CV A 501
source : AC3

14) chain A
residue 185
type
sequence E
description BINDING SITE FOR RESIDUE 2CV A 501
source : AC3

15) chain A
residue 204
type
sequence N
description BINDING SITE FOR RESIDUE 2CV A 501
source : AC3

16) chain B
residue 160
type
sequence V
description BINDING SITE FOR RESIDUE 2CV A 501
source : AC3

17) chain B
residue 164
type
sequence T
description BINDING SITE FOR RESIDUE 2CV A 501
source : AC3

18) chain A
residue 289
type
sequence L
description BINDING SITE FOR RESIDUE 2CV A 502
source : AC4

19) chain A
residue 205
type
sequence R
description BINDING SITE FOR RESIDUE 2CV A 503
source : AC5

20) chain A
residue 315
type
sequence F
description BINDING SITE FOR RESIDUE 2CV A 503
source : AC5

21) chain B
residue 148
type
sequence R
description BINDING SITE FOR RESIDUE 2CV A 503
source : AC5

22) chain B
residue 152
type
sequence L
description BINDING SITE FOR RESIDUE 2CV A 503
source : AC5

23) chain B
residue 157
type
sequence R
description BINDING SITE FOR RESIDUE 2CV A 503
source : AC5

24) chain A
residue 51
type
sequence V
description BINDING SITE FOR RESIDUE 2CV A 504
source : AC6

25) chain A
residue 334
type
sequence A
description BINDING SITE FOR RESIDUE 2CV A 504
source : AC6

26) chain A
residue 163
type
sequence C
description BINDING SITE FOR RESIDUE 2CV A 505
source : AC7

27) chain B
residue 181
type
sequence W
description BINDING SITE FOR RESIDUE 2CV A 505
source : AC7

28) chain A
residue 101
type
sequence L
description BINDING SITE FOR RESIDUE Y00 A 601
source : AC8

29) chain A
residue 102
type
sequence V
description BINDING SITE FOR RESIDUE Y00 A 601
source : AC8

30) chain A
residue 117
type
sequence W
description BINDING SITE FOR RESIDUE Y00 A 601
source : AC8

31) chain A
residue 121
type
sequence D
description BINDING SITE FOR RESIDUE Y00 A 601
source : AC8

32) chain A
residue 201
type
sequence F
description BINDING SITE FOR RESIDUE Y00 A 601
source : AC8

33) chain A
residue 211
type
sequence S
description BINDING SITE FOR RESIDUE Y00 A 601
source : AC8

34) chain A
residue 306
type
sequence F
description BINDING SITE FOR RESIDUE Y00 A 601
source : AC8

35) chain A
residue 310
type
sequence N
description BINDING SITE FOR RESIDUE Y00 A 601
source : AC8

36) chain A
residue 329
type
sequence N
description BINDING SITE FOR RESIDUE Y00 A 601
source : AC8

37) chain A
residue 330
type
sequence W
description BINDING SITE FOR RESIDUE Y00 A 601
source : AC8

38) chain A
residue 333
type
sequence Y
description BINDING SITE FOR RESIDUE Y00 A 601
source : AC8

39) chain A
residue 192
type
sequence C
description BINDING SITE FOR RESIDUE NA A 1359
source : AC9

40) chain A
residue 195
type
sequence D
description BINDING SITE FOR RESIDUE NA A 1359
source : AC9

41) chain A
residue 198
type
sequence C
description BINDING SITE FOR RESIDUE NA A 1359
source : AC9

42) chain A
residue 205
type
sequence R
description BINDING SITE FOR RESIDUE Y01 B 401
source : BC1

43) chain A
residue 206
type
sequence A
description BINDING SITE FOR RESIDUE Y01 B 401
source : BC1

44) chain A
residue 209
type
sequence I
description BINDING SITE FOR RESIDUE Y01 B 401
source : BC1

45) chain B
residue 130
type
sequence E
description BINDING SITE FOR RESIDUE Y01 B 401
source : BC1

46) chain B
residue 133
type
sequence C
description BINDING SITE FOR RESIDUE Y01 B 401
source : BC1

47) chain B
residue 157
type
sequence R
description BINDING SITE FOR RESIDUE Y01 B 401
source : BC1

48) chain B
residue 160
type
sequence V
description BINDING SITE FOR RESIDUE Y01 B 401
source : BC1

49) chain B
residue 161
type
sequence I
description BINDING SITE FOR RESIDUE Y01 B 401
source : BC1

50) chain B
residue 164
type
sequence T
description BINDING SITE FOR RESIDUE Y01 B 401
source : BC1

51) chain B
residue 168
type
sequence I
description BINDING SITE FOR RESIDUE Y01 B 401
source : BC1

52) chain B
residue 214
type
sequence I
description BINDING SITE FOR RESIDUE Y01 B 401
source : BC1

53) chain B
residue 78
type
sequence L
description BINDING SITE FOR RESIDUE Y01 B 402
source : BC2

54) chain B
residue 155
type
sequence R
description BINDING SITE FOR RESIDUE Y01 B 402
source : BC2

55) chain B
residue 159
type
sequence K
description BINDING SITE FOR RESIDUE Y01 B 402
source : BC2

56) chain B
residue 166
type
sequence W
description BINDING SITE FOR RESIDUE Y01 B 402
source : BC2

57) chain A
residue 160
type
sequence V
description BINDING SITE FOR RESIDUE 2CV B 501
source : BC3

58) chain A
residue 164
type
sequence T
description BINDING SITE FOR RESIDUE 2CV B 501
source : BC3

59) chain B
residue 180
type
sequence H
description BINDING SITE FOR RESIDUE 2CV B 501
source : BC3

60) chain B
residue 181
type
sequence W
description BINDING SITE FOR RESIDUE 2CV B 501
source : BC3

61) chain B
residue 183
type
sequence R
description BINDING SITE FOR RESIDUE 2CV B 501
source : BC3

62) chain B
residue 184
type
sequence D
description BINDING SITE FOR RESIDUE 2CV B 501
source : BC3

63) chain B
residue 185
type
sequence E
description BINDING SITE FOR RESIDUE 2CV B 501
source : BC3

64) chain B
residue 231
type
sequence Y
description BINDING SITE FOR RESIDUE 2CV B 502
source : BC4

65) chain B
residue 286
type
sequence H
description BINDING SITE FOR RESIDUE 2CV B 502
source : BC4

66) chain B
residue 289
type
sequence L
description BINDING SITE FOR RESIDUE 2CV B 502
source : BC4

67) chain A
residue 157
type
sequence R
description BINDING SITE FOR RESIDUE 2CV B 503
source : BC5

68) chain B
residue 205
type
sequence R
description BINDING SITE FOR RESIDUE 2CV B 503
source : BC5

69) chain B
residue 315
type
sequence F
description BINDING SITE FOR RESIDUE 2CV B 503
source : BC5

70) chain A
residue 185
type
sequence E
description BINDING SITE FOR RESIDUE 2CV B 505
source : BC6

71) chain B
residue 163
type
sequence C
description BINDING SITE FOR RESIDUE 2CV B 505
source : BC6

72) chain B
residue 102
type
sequence V
description BINDING SITE FOR RESIDUE Y00 B 601
source : BC7

73) chain B
residue 117
type
sequence W
description BINDING SITE FOR RESIDUE Y00 B 601
source : BC7

74) chain B
residue 121
type
sequence D
description BINDING SITE FOR RESIDUE Y00 B 601
source : BC7

75) chain B
residue 125
type
sequence V
description BINDING SITE FOR RESIDUE Y00 B 601
source : BC7

76) chain B
residue 211
type
sequence S
description BINDING SITE FOR RESIDUE Y00 B 601
source : BC7

77) chain B
residue 307
type
sequence F
description BINDING SITE FOR RESIDUE Y00 B 601
source : BC7

78) chain B
residue 310
type
sequence N
description BINDING SITE FOR RESIDUE Y00 B 601
source : BC7

79) chain B
residue 329
type
sequence N
description BINDING SITE FOR RESIDUE Y00 B 601
source : BC7

80) chain B
residue 330
type
sequence W
description BINDING SITE FOR RESIDUE Y00 B 601
source : BC7

81) chain B
residue 333
type
sequence Y
description BINDING SITE FOR RESIDUE Y00 B 601
source : BC7

82) chain A
residue 127-143
type prosite
sequence ASIETLCVIAIDRYLAI
description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAIDRYLaI
source prosite : PS00237

83) chain A
residue 39-67
type TRANSMEM
sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG
description Helical; Name=1
source Swiss-Prot : SWS_FT_FI1

84) chain B
residue 39-67
type TRANSMEM
sequence QWEAGMSLLMALVVLLIVAGNVLVIAAIG
description Helical; Name=1
source Swiss-Prot : SWS_FT_FI1

85) chain A
residue 121
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4
source Swiss-Prot : SWS_FT_FI10

86) chain A
residue 211
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4
source Swiss-Prot : SWS_FT_FI10

87) chain A
residue 357
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4
source Swiss-Prot : SWS_FT_FI10

88) chain B
residue 121
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4
source Swiss-Prot : SWS_FT_FI10

89) chain B
residue 211
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4
source Swiss-Prot : SWS_FT_FI10

90) chain B
residue 357
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4
source Swiss-Prot : SWS_FT_FI10

91) chain A
residue 68-76
type TOPO_DOM
sequence STQRLQTLT
description Cytoplasmic => ECO:0000269|PubMed:18594507
source Swiss-Prot : SWS_FT_FI2

92) chain A
residue 138-155
type TOPO_DOM
sequence DRYLAITSPFRYQSLMTR
description Cytoplasmic => ECO:0000269|PubMed:18594507
source Swiss-Prot : SWS_FT_FI2

93) chain A
residue 232-313
type TOPO_DOM
sequence REAKEQSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNI
VN
description Cytoplasmic => ECO:0000269|PubMed:18594507
source Swiss-Prot : SWS_FT_FI2

94) chain B
residue 68-76
type TOPO_DOM
sequence STQRLQTLT
description Cytoplasmic => ECO:0000269|PubMed:18594507
source Swiss-Prot : SWS_FT_FI2

95) chain B
residue 138-155
type TOPO_DOM
sequence DRYLAITSPFRYQSLMTR
description Cytoplasmic => ECO:0000269|PubMed:18594507
source Swiss-Prot : SWS_FT_FI2

96) chain B
residue 232-313
type TOPO_DOM
sequence REAKEQIRKIDRASKRKTSRVMLMREHKALKTLGIIMGVF
TLCWLPFFLVNIVN
description Cytoplasmic => ECO:0000269|PubMed:18594507
source Swiss-Prot : SWS_FT_FI2

97) chain A
residue 77-103
type TRANSMEM
sequence NLFITSLACADLVVGLLVVPFGATLVV
description Helical; Name=2
source Swiss-Prot : SWS_FT_FI3

98) chain B
residue 77-103
type TRANSMEM
sequence NLFITSLACADLVVGLLVVPFGATLVV
description Helical; Name=2
source Swiss-Prot : SWS_FT_FI3

99) chain A
residue 104-115
type TOPO_DOM
sequence RGTWLWGSFLCE
description Extracellular => ECO:0000269|PubMed:18594507
source Swiss-Prot : SWS_FT_FI4

100) chain A
residue 180-205
type TOPO_DOM
sequence HWWRDEDPQALKCYQDPGCCDFVTNR
description Extracellular => ECO:0000269|PubMed:18594507
source Swiss-Prot : SWS_FT_FI4

101) chain A
residue 344-348
type TOPO_DOM
sequence CRSPD
description Extracellular => ECO:0000269|PubMed:18594507
source Swiss-Prot : SWS_FT_FI4

102) chain B
residue 104-115
type TOPO_DOM
sequence RGTWLWGSFLCE
description Extracellular => ECO:0000269|PubMed:18594507
source Swiss-Prot : SWS_FT_FI4

103) chain B
residue 180-205
type TOPO_DOM
sequence HWWRDEDPQALKCYQDPGCCDFVTNR
description Extracellular => ECO:0000269|PubMed:18594507
source Swiss-Prot : SWS_FT_FI4

104) chain B
residue 344-348
type TOPO_DOM
sequence CRSPD
description Extracellular => ECO:0000269|PubMed:18594507
source Swiss-Prot : SWS_FT_FI4

105) chain A
residue 116-137
type TRANSMEM
sequence LWTSLDVLCVTASIETLCVIAI
description Helical; Name=3
source Swiss-Prot : SWS_FT_FI5

106) chain B
residue 116-137
type TRANSMEM
sequence LWTSLDVLCVTASIETLCVIAI
description Helical; Name=3
source Swiss-Prot : SWS_FT_FI5

107) chain A
residue 156-179
type TRANSMEM
sequence ARAKVIICTVWAISALVSFLPIMM
description Helical; Name=4
source Swiss-Prot : SWS_FT_FI6

108) chain B
residue 156-179
type TRANSMEM
sequence ARAKVIICTVWAISALVSFLPIMM
description Helical; Name=4
source Swiss-Prot : SWS_FT_FI6

109) chain A
residue 206-231
type TRANSMEM
sequence AYAIASSIISFYIPLLIMIFVALRVY
description Helical; Name=5
source Swiss-Prot : SWS_FT_FI7

110) chain B
residue 206-231
type TRANSMEM
sequence AYAIASSIISFYIPLLIMIFVALRVY
description Helical; Name=5
source Swiss-Prot : SWS_FT_FI7

111) chain A
residue 314-343
type TRANSMEM
sequence VFNRDLVPDWLFVAFNWLGYANSAMNPIIY
description Helical; Name=6
source Swiss-Prot : SWS_FT_FI8

112) chain B
residue 314-343
type TRANSMEM
sequence VFNRDLVPDWLFVAFNWLGYANSAMNPIIY
description Helical; Name=6
source Swiss-Prot : SWS_FT_FI8


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