eF-site ID 2xzo-A PDB Code 2xzo Chain A click to enlarge Title Upf1 helicase - RNA complex Classification HYDROLASE/RNA Compound REGULATOR OF NONSENSE TRANSCRIPTS 1 Source Homo sapiens (Human) (2XZO) Sequence A:  GHMRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITV RWDLGLNKKRIAYFTLPRLMQGDEICLRYKGDLAPLWKGI GHVIKVPDNYGDEIAIELRSSVGAPVEVTHNFQVDFVWKS TSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKC QLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTG KTVTSATIVYHLARQGNGPVLVCAPSNIAVDQLTEKIHQT GLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKL QQLKELSSADEKRYRALKRTAERELLMNADVICCTCVGAG DPRLAKMQFRSILIDESTQATEPECMVPVVLGAKQLILVG DHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQ YRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQ PDKPMFFYVTQGQEEIASSGTSYLNRTEAANVEKITTKLL KAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEV EIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNV ALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVEG PLNNLRESLMQFS Description Functional site 1) chain A residue 472 type sequence N description BINDING SITE FOR RESIDUE 1PE B 1 source : AC1 2) chain A residue 473 type sequence H description BINDING SITE FOR RESIDUE 1PE B 1 source : AC1 3) chain A residue 474 type sequence S description BINDING SITE FOR RESIDUE 1PE B 1 source : AC1 4) chain A residue 496 type sequence T description BINDING SITE FOR RESIDUE 1PE B 1 source : AC1 5) chain A residue 698 type sequence L description BINDING SITE FOR RESIDUE 1PE B 1 source : AC1 6) chain A residue 699 type sequence Q description BINDING SITE FOR RESIDUE 1PE B 1 source : AC1 7) chain A residue 700 type sequence V description BINDING SITE FOR RESIDUE 1PE B 1 source : AC1 8) chain A residue 702 type sequence Y description BINDING SITE FOR RESIDUE 1PE B 1 source : AC1 9) chain A residue 462 type sequence R description BINDING SITE FOR RESIDUE 1PE B 2 source : AC2 10) chain A residue 464 type sequence T description BINDING SITE FOR RESIDUE 1PE B 2 source : AC2 11) chain A residue 465 type sequence A description BINDING SITE FOR RESIDUE 1PE B 2 source : AC2 12) chain A residue 466 type sequence Q description BINDING SITE FOR RESIDUE 1PE B 2 source : AC2 13) chain A residue 421 type sequence D description BINDING SITE FOR RESIDUE 1PE B 6 source : AC3 14) chain A residue 422 type sequence R description BINDING SITE FOR RESIDUE 1PE B 6 source : AC3 15) chain A residue 425 type sequence S description BINDING SITE FOR RESIDUE 1PE B 6 source : AC3 16) chain A residue 426 type sequence A description BINDING SITE FOR RESIDUE 1PE B 6 source : AC3 17) chain A residue 621 type sequence G description BINDING SITE FOR RESIDUE 1PE B 6 source : AC3 18) chain A residue 469 type sequence P description BINDING SITE FOR RESIDUE ADP E 480 source : AC4 19) chain A residue 470 type sequence D description BINDING SITE FOR RESIDUE ADP E 480 source : AC4 20) chain A residue 472 type sequence N description BINDING SITE FOR RESIDUE ADP E 480 source : AC4 21) chain A residue 475 type sequence Q description BINDING SITE FOR RESIDUE ADP E 480 source : AC4 22) chain A residue 495 type sequence G description BINDING SITE FOR RESIDUE ADP E 480 source : AC4 23) chain A residue 496 type sequence T description BINDING SITE FOR RESIDUE ADP E 480 source : AC4 24) chain A residue 497 type sequence G description BINDING SITE FOR RESIDUE ADP E 480 source : AC4 25) chain A residue 498 type sequence K description BINDING SITE FOR RESIDUE ADP E 480 source : AC4 26) chain A residue 499 type sequence T description BINDING SITE FOR RESIDUE ADP E 480 source : AC4 27) chain A residue 500 type sequence V description BINDING SITE FOR RESIDUE ADP E 480 source : AC4 28) chain A residue 702 type sequence Y description BINDING SITE FOR RESIDUE ADP E 480 source : AC4 29) chain A residue 703 type sequence R description BINDING SITE FOR RESIDUE ADP E 480 source : AC4 30) chain A residue 833 type sequence E description BINDING SITE FOR RESIDUE ADP E 480 source : AC4 31) chain A residue 494 type sequence P description BINDING SITE FOR RESIDUE ALF E 481 source : AC5 32) chain A residue 495 type sequence G description BINDING SITE FOR RESIDUE ALF E 481 source : AC5 33) chain A residue 498 type sequence K description BINDING SITE FOR RESIDUE ALF E 481 source : AC5 34) chain A residue 637 type sequence E description BINDING SITE FOR RESIDUE ALF E 481 source : AC5 35) chain A residue 665 type sequence Q description BINDING SITE FOR RESIDUE ALF E 481 source : AC5 36) chain A residue 703 type sequence R description BINDING SITE FOR RESIDUE ALF E 481 source : AC5 37) chain A residue 831 type sequence G description BINDING SITE FOR RESIDUE ALF E 481 source : AC5 38) chain A residue 865 type sequence R description BINDING SITE FOR RESIDUE ALF E 481 source : AC5 39) chain A residue 499 type sequence T description BINDING SITE FOR RESIDUE MG E 482 source : AC6 40) chain A residue 806 type sequence Y description BINDING SITE FOR RESIDUE MG E 483 source : AC7 41) chain A residue 807 type sequence M description BINDING SITE FOR RESIDUE MG E 483 source : AC7 42) chain A residue 809 type sequence F description BINDING SITE FOR RESIDUE MG E 483 source : AC7 43) chain A residue 810 type sequence S description BINDING SITE FOR RESIDUE MG E 483 source : AC7 44) chain A residue 812 type sequence S description BINDING SITE FOR RESIDUE MG E 483 source : AC7 45) chain A residue 815 type sequence T description BINDING SITE FOR RESIDUE MG E 483 source : AC7 46) chain A residue 565 type MOD_RES sequence I description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 47) chain A residue 486 type BINDING sequence P description BINDING => ECO:0000269|PubMed:21419344 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 676 type BINDING sequence A description BINDING => ECO:0000269|PubMed:21419344 source Swiss-Prot : SWS_FT_FI1 49) chain A residue 713 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21419344 source Swiss-Prot : SWS_FT_FI1 50) chain A residue 844 type BINDING sequence A description BINDING => ECO:0000269|PubMed:21419344 source Swiss-Prot : SWS_FT_FI1 51) chain A residue 506 type BINDING sequence V description BINDING => ECO:0007744|PDB:2GJK source Swiss-Prot : SWS_FT_FI2

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