eF-site ID 2xyf-B
PDB Code 2xyf
Chain B

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Title HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents
Classification HYDROLASE
Compound PROTEASE
Source Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) (POL_HV1B1)
Sequence B:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG
RWKPKMIGGIGGFIKVRQYDQIPIEICGHKAIGTVLVGPT
PTNVIGRNLLTQIGCTLNF
Description


Functional site

1) chain B
residue 123
type
sequence L
description BINDING SITE FOR RESIDUE G40 B 1200
source : AC1

2) chain B
residue 125
type
sequence D
description BINDING SITE FOR RESIDUE G40 B 1200
source : AC1

3) chain B
residue 127
type
sequence G
description BINDING SITE FOR RESIDUE G40 B 1200
source : AC1

4) chain B
residue 128
type
sequence A
description BINDING SITE FOR RESIDUE G40 B 1200
source : AC1

5) chain B
residue 129
type
sequence D
description BINDING SITE FOR RESIDUE G40 B 1200
source : AC1

6) chain B
residue 148
type
sequence G
description BINDING SITE FOR RESIDUE G40 B 1200
source : AC1

7) chain B
residue 149
type
sequence G
description BINDING SITE FOR RESIDUE G40 B 1200
source : AC1

8) chain B
residue 150
type
sequence I
description BINDING SITE FOR RESIDUE G40 B 1200
source : AC1

9) chain B
residue 153
type
sequence F
description BINDING SITE FOR RESIDUE G40 B 1200
source : AC1

10) chain B
residue 181
type
sequence P
description BINDING SITE FOR RESIDUE G40 B 1200
source : AC1

11) chain B
residue 182
type
sequence T
description BINDING SITE FOR RESIDUE G40 B 1200
source : AC1

12) chain B
residue 125
type ACT_SITE
sequence D
description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094
source Swiss-Prot : SWS_FT_FI1

13) chain B
residue 199
type SITE
sequence F
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI2


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