eF-site ID 2xyf-B PDB Code 2xyf Chain B click to enlarge Title HIV-1 Inhibitors with a Tertiary-Alcohol-containing Transition-State Mimic and various P2 and P1 prime Substituents Classification HYDROLASE Compound PROTEASE Source Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) (POL_HV1B1) Sequence B:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG RWKPKMIGGIGGFIKVRQYDQIPIEICGHKAIGTVLVGPT PTNVIGRNLLTQIGCTLNF Description Functional site 1) chain B residue 123 type sequence L description BINDING SITE FOR RESIDUE G40 B 1200 source : AC1 2) chain B residue 125 type sequence D description BINDING SITE FOR RESIDUE G40 B 1200 source : AC1 3) chain B residue 127 type sequence G description BINDING SITE FOR RESIDUE G40 B 1200 source : AC1 4) chain B residue 128 type sequence A description BINDING SITE FOR RESIDUE G40 B 1200 source : AC1 5) chain B residue 129 type sequence D description BINDING SITE FOR RESIDUE G40 B 1200 source : AC1 6) chain B residue 148 type sequence G description BINDING SITE FOR RESIDUE G40 B 1200 source : AC1 7) chain B residue 149 type sequence G description BINDING SITE FOR RESIDUE G40 B 1200 source : AC1 8) chain B residue 150 type sequence I description BINDING SITE FOR RESIDUE G40 B 1200 source : AC1 9) chain B residue 153 type sequence F description BINDING SITE FOR RESIDUE G40 B 1200 source : AC1 10) chain B residue 181 type sequence P description BINDING SITE FOR RESIDUE G40 B 1200 source : AC1 11) chain B residue 182 type sequence T description BINDING SITE FOR RESIDUE G40 B 1200 source : AC1 12) chain B residue 125 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 13) chain B residue 199 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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