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eF-site ID
|
2xwj-I |
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PDB Code
|
2xwj |
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Chain
|
I |
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click to enlarge
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Title
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Crystal Structure of Complement C3b in Complex with Factor B |
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Classification
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HYDROLASE |
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Compound
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COMPLEMENT C3 BETA CHAIN |
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Source
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ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS; |
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Sequence
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I: |
GSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTR
TCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEY
WPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQ
TAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRG
LTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAF
LSSLTETIEGVDAEPSGSMNIYLVLDGSGSIGASDFTGAK
KCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADSS
NADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPD
DVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLY
IGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQ
HVFKVKDMENLEDVFYQMIDESQSLSLCGMVWEHDYHKQP
WQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKE
HSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYD
YDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTT
CQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKG
SCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNT
CRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQV
PAHARDFHINLFQVLPWLKEKLQDEDLGFLAA
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Description
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Functional site
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1)
|
chain |
I |
| residue |
501 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
I |
| residue |
551 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI1
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|
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3)
|
chain |
I |
| residue |
674 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Charge relay system
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| source |
Swiss-Prot : SWS_FT_FI1
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|
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4)
|
chain |
I |
| residue |
97 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6546754
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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5)
|
chain |
I |
| residue |
260 |
| type |
CARBOHYD |
| sequence |
D
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6546754
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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6)
|
chain |
I |
| residue |
117 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754
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| source |
Swiss-Prot : SWS_FT_FI3
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|
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7)
|
chain |
I |
| residue |
497-502 |
| type |
prosite |
| sequence |
LTAAHC
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| description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
|
| source |
prosite : PS00134
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8)
|
chain |
I |
| residue |
668-679 |
| type |
prosite |
| sequence |
NTCRGDSGGPLI
|
| description |
TRYPSIN_SER Serine proteases, trypsin family, serine active site. NTcrGDSGGPLI
|
| source |
prosite : PS00135
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|
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9)
|
chain |
I |
| residue |
266 |
| type |
CARBOHYD |
| sequence |
K
|
| description |
N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:2006911
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
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10)
|
chain |
I |
| residue |
353 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754
|
| source |
Swiss-Prot : SWS_FT_FI5
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