eF-site ID 2xwj-H
PDB Code 2xwj
Chain H

click to enlarge
Title Crystal Structure of Complement C3b in Complex with Factor B
Classification HYDROLASE
Compound COMPLEMENT C3 BETA CHAIN
Source ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS;
Sequence H:  DEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLM
NIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFI
DLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPA
FCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVE
VKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPER
LGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMT
EDAVDAERLKHLIVTPSGCGEENMIGMTPTVIAVHYLDET
EQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVK
RAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEK
QKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISL
QEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAI
AGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVE
ATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQA
TFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRI
HWESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAK
AKDQLTCNKFDLKVTIKPAPKNTMILEICTRYRGDQDATM
SILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSD
RNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVY
AYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFI
QKDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYI
MAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHY
LMWGLSSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDEEN
QKQCQDLGAFTESMVVFGCPN
Description


Functional site
1) chain H
residue 946
type CARBOHYD
sequence S
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:2006911
source Swiss-Prot : SWS_FT_FI4
2) chain H
residue 1299
type CARBOHYD
sequence S
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:2006911
source Swiss-Prot : SWS_FT_FI4
3) chain H
residue 1551
type CARBOHYD
sequence S
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:2006911
source Swiss-Prot : SWS_FT_FI4
4) chain H
residue 1595
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952
source Swiss-Prot : SWS_FT_FI6
5) chain H
residue 988
type CROSSLNK
sequence C
description Isoglutamyl cysteine thioester (Cys-Gln)
source Swiss-Prot : SWS_FT_FI7
6) chain H
residue 991
type CROSSLNK
sequence E
description Isoglutamyl cysteine thioester (Cys-Gln)
source Swiss-Prot : SWS_FT_FI7

Display surface

Download
Links