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eF-site ID
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2xwj-B |
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PDB Code
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2xwj |
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Chain
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B |
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click to enlarge
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Title
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Crystal Structure of Complement C3b in Complex with Factor B |
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Classification
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HYDROLASE |
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Compound
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COMPLEMENT C3 BETA CHAIN |
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Source
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ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS; |
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Sequence
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B: |
DEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLM
NIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFI
DLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPA
FCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVE
VKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPER
LGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMT
EDAVDAERLKHLIVTPSGCGEENMIGMTPTVIAVHYLDET
EQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVK
RAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEK
QKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISL
QEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAI
AGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVE
ATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQA
TFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRI
HWESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAK
AKDQLTCNKFDLKVTIKPAPKNTMILEICTRYRGDQDATM
SILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSD
RNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVY
AYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFI
QKDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYI
MAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHY
LMWGLSSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDEEN
QKQCQDLGAFTESMVVFGCPN
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Description
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Functional site
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1)
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chain |
B |
| residue |
1595 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952
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| source |
Swiss-Prot : SWS_FT_FI6
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2)
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chain |
B |
| residue |
988 |
| type |
CROSSLNK |
| sequence |
C
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| description |
Isoglutamyl cysteine thioester (Cys-Gln)
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| source |
Swiss-Prot : SWS_FT_FI7
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3)
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chain |
B |
| residue |
991 |
| type |
CROSSLNK |
| sequence |
E
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| description |
Isoglutamyl cysteine thioester (Cys-Gln)
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| source |
Swiss-Prot : SWS_FT_FI7
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4)
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chain |
B |
| residue |
985-993 |
| type |
prosite |
| sequence |
PSGCGEENM
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| description |
ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEEnM
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| source |
prosite : PS00477
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