eF-site ID 2xrw-A PDB Code 2xrw Chain A click to enlarge Title Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4 Classification TRANSCRIPTION Compound MITOGEN-ACTIVATED PROTEIN KINASE 8 Source null (NFAC3_HUMAN) Sequence A:  GSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIV CAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCV NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK SDCTLKILDFGLRYYRAPEVILGMGYKENVDIWSVGCIMG EMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTV RTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARD LLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPK IPDKQLDEREHTIEEWKELIYKEVMDLEH Description Functional site 1) chain A residue 32 type sequence I description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 2) chain A residue 33 type sequence G description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 3) chain A residue 34 type sequence S description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 4) chain A residue 35 type sequence G description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 5) chain A residue 38 type sequence G description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 6) chain A residue 40 type sequence V description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 7) chain A residue 53 type sequence A description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 8) chain A residue 55 type sequence K description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 9) chain A residue 108 type sequence M description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 10) chain A residue 109 type sequence E description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 11) chain A residue 111 type sequence M description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 12) chain A residue 114 type sequence N description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 13) chain A residue 155 type sequence S description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 14) chain A residue 156 type sequence N description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 15) chain A residue 168 type sequence L description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 16) chain A residue 169 type sequence D description BINDING SITE FOR RESIDUE ANP A 1367 source : AC1 17) chain A residue 239 type sequence E description BINDING SITE FOR RESIDUE GOL A 1368 source : AC2 18) chain A residue 266 type sequence Y description BINDING SITE FOR RESIDUE GOL A 1368 source : AC2 19) chain A residue 267 type sequence A description BINDING SITE FOR RESIDUE GOL A 1368 source : AC2 20) chain A residue 268 type sequence G description BINDING SITE FOR RESIDUE GOL A 1368 source : AC2 21) chain A residue 269 type sequence Y description BINDING SITE FOR RESIDUE GOL A 1368 source : AC2 22) chain A residue 80 type sequence V description BINDING SITE FOR RESIDUE GOL A 1369 source : AC3 23) chain A residue 81 type sequence N description BINDING SITE FOR RESIDUE GOL A 1369 source : AC3 24) chain A residue 141 type sequence H description BINDING SITE FOR RESIDUE GOL A 1369 source : AC3 25) chain A residue 333 type sequence P description BINDING SITE FOR RESIDUE GOL A 1369 source : AC3 26) chain A residue 335 type sequence P description BINDING SITE FOR RESIDUE GOL A 1369 source : AC3 27) chain A residue 147-159 type prosite sequence IIHRDLKPSNIVV description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpsNIVV source prosite : PS00108 28) chain A residue 61-163 type prosite sequence FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEE FQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK HLHSAGIIHRDLKPSNIVVKSDC description MAPK MAP kinase signature. FqnqthakrayRElvlmkcvnhkniigllnvftpqksleefqdvyivmelmdanlcqviqmeldhermsyllyqmlcgikhlhsagiih..........RDlKpsnivvksdC source prosite : PS01351 29) chain A residue 151 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 55 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 32 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 116 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000250|UniProtKB:P49185 source Swiss-Prot : SWS_FT_FI3

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