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eF-site ID
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2xra-AHL |
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PDB Code
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2xra |
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Chain
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A, H, L |
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click to enlarge
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Title
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crystal structure of the HK20 Fab in complex with a gp41 mimetic 5- Helix |
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Classification
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IMMUNE SYSTEM |
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Compound
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TRANSMEMBRANE PROTEIN GP41 |
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Source
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ORGANISM_COMMON: HUMAN; ORGANISM_SCIENTIFIC: HOMO SAPIENS; |
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Sequence
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A: |
QLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILA
GGTTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLEG
SGGQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQAR
ILGHTTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELL
EGSQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQAR
ILA
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| H: |
QLVESGAEVKKPGSSVKVSCKTSGGTFNRLAMSWVRQAPG
QGLEWMGGIMPIFDITNYAQKFQGRVTIITDESTSTAYME
LRSLTSEDSAVYYCARASYSSSSPYAFDIWGQGTMVTVSS
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS
WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQT
YICNVNHKPSNTKVDKKVEPKSC
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| L: |
DIQMTQSPSSLSPSVGDRVTITCQASQDIRNHLNWYQQKP
GKAPKLLIYDASNLATGVPSRFSGSGSGTDFTFTISSLQP
EDLATYYCQHYDDLPRITFGQGTRLEIKRTVAAPSVFIFP
PSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS
QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQ
GLSSPVTKSFNRGGC
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Description
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Functional site
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1)
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chain |
L |
| residue |
192-198 |
| type |
prosite |
| sequence |
YACEVTH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
| source |
prosite : PS00290
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2)
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chain |
H |
| residue |
194-200 |
| type |
prosite |
| sequence |
YICNVNH
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| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
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| source |
prosite : PS00290
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3)
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chain |
A |
| residue |
3637 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04083, ECO:0000269|PubMed:26972002
|
| source |
Swiss-Prot : SWS_FT_FI1
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