eF-site ID 2xq4-ABCDE PDB Code 2xq4 Chain A, B, C, D, E click to enlarge Title Pentameric ligand gated ion channel GLIC in complex with tetramethylarsonium (TMAs) Classification MEMBRANE PROTEIN Compound GLR4197 PROTEIN Source (Q7NDN8_GLOVI) Sequence A:  PPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSW KDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDA DVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLH IYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTA VVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLF ILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLP KTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPAR AASITRASRIAFPVVFLLANIILAFLFFGF B:  PPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSW KDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDA DVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLH IYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTA VVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLF ILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLP KTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPAR AASITRASRIAFPVVFLLANIILAFLFFGF C:  PPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSW KDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDA DVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLH IYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTA VVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLF ILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLP KTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPAR AASITRASRIAFPVVFLLANIILAFLFFGF D:  PPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSW KDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDA DVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLH IYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTA VVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLF ILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLP KTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPAR AASITRASRIAFPVVFLLANIILAFLFFGF E:  PPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSW KDRRLAFDPVRSGVRVKTYEPEAIWIPEIRFVNVENARDA DVVDISVSPDGTVQYLERFSARVLSPLDFRRYPFDSQTLH IYLIVRSVDTRNIVLAVDLEKVGKNDDVFLTGWDIESFTA VVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILPMLF ILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLP KTPYMTYTGAIIFMIYLFYFVAVIEVTVQHYLKVESQPAR AASITRASRIAFPVVFLLANIILAFLFFGF Description (1)  GLR4197 PROTEIN Functional site 1) chain A residue 193-215 type TRANSMEM sequence YFSYIPNIILPMLFILFISWTAF description Helical source Swiss-Prot : SWS_FT_FI2 2) chain C residue 219-243 type TRANSMEM sequence SYEANVTLVVSTLIAHIAFNILVET description Helical source Swiss-Prot : SWS_FT_FI2 3) chain C residue 252-280 type TRANSMEM sequence TYTGAIIFMIYLFYFVAVIEVTVQHYLKV description Helical source Swiss-Prot : SWS_FT_FI2 4) chain C residue 284-316 type TRANSMEM sequence PARAASITRASRIAFPVVFLLANIILAFLFFGF description Helical source Swiss-Prot : SWS_FT_FI2 5) chain D residue 193-215 type TRANSMEM sequence YFSYIPNIILPMLFILFISWTAF description Helical source Swiss-Prot : SWS_FT_FI2 6) chain D residue 219-243 type TRANSMEM sequence SYEANVTLVVSTLIAHIAFNILVET description Helical source Swiss-Prot : SWS_FT_FI2 7) chain D residue 252-280 type TRANSMEM sequence TYTGAIIFMIYLFYFVAVIEVTVQHYLKV description Helical source Swiss-Prot : SWS_FT_FI2 8) chain D residue 284-316 type TRANSMEM sequence PARAASITRASRIAFPVVFLLANIILAFLFFGF description Helical source Swiss-Prot : SWS_FT_FI2 9) chain E residue 193-215 type TRANSMEM sequence YFSYIPNIILPMLFILFISWTAF description Helical source Swiss-Prot : SWS_FT_FI2 10) chain E residue 219-243 type TRANSMEM sequence SYEANVTLVVSTLIAHIAFNILVET description Helical source Swiss-Prot : SWS_FT_FI2 11) chain E residue 252-280 type TRANSMEM sequence TYTGAIIFMIYLFYFVAVIEVTVQHYLKV description Helical source Swiss-Prot : SWS_FT_FI2 12) chain A residue 219-243 type TRANSMEM sequence SYEANVTLVVSTLIAHIAFNILVET description Helical source Swiss-Prot : SWS_FT_FI2 13) chain E residue 284-316 type TRANSMEM sequence PARAASITRASRIAFPVVFLLANIILAFLFFGF description Helical source Swiss-Prot : SWS_FT_FI2 14) chain A residue 252-280 type TRANSMEM sequence TYTGAIIFMIYLFYFVAVIEVTVQHYLKV description Helical source Swiss-Prot : SWS_FT_FI2 15) chain A residue 284-316 type TRANSMEM sequence PARAASITRASRIAFPVVFLLANIILAFLFFGF description Helical source Swiss-Prot : SWS_FT_FI2 16) chain B residue 193-215 type TRANSMEM sequence YFSYIPNIILPMLFILFISWTAF description Helical source Swiss-Prot : SWS_FT_FI2 17) chain B residue 219-243 type TRANSMEM sequence SYEANVTLVVSTLIAHIAFNILVET description Helical source Swiss-Prot : SWS_FT_FI2 18) chain B residue 252-280 type TRANSMEM sequence TYTGAIIFMIYLFYFVAVIEVTVQHYLKV description Helical source Swiss-Prot : SWS_FT_FI2 19) chain B residue 284-316 type TRANSMEM sequence PARAASITRASRIAFPVVFLLANIILAFLFFGF description Helical source Swiss-Prot : SWS_FT_FI2 20) chain C residue 193-215 type TRANSMEM sequence YFSYIPNIILPMLFILFISWTAF description Helical source Swiss-Prot : SWS_FT_FI2 21) chain E residue 244-251 type TOPO_DOM sequence NLPKTPYM description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 244-251 type TOPO_DOM sequence NLPKTPYM description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 244-251 type TOPO_DOM sequence NLPKTPYM description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 24) chain C residue 244-251 type TOPO_DOM sequence NLPKTPYM description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 244-251 type TOPO_DOM sequence NLPKTPYM description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 216-218 type TOPO_DOM sequence WST description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 27) chain E residue 281-283 type TOPO_DOM sequence ESQ description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 28) chain A residue 281-283 type TOPO_DOM sequence ESQ description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 29) chain B residue 216-218 type TOPO_DOM sequence WST description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 30) chain B residue 281-283 type TOPO_DOM sequence ESQ description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 31) chain C residue 216-218 type TOPO_DOM sequence WST description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 32) chain C residue 281-283 type TOPO_DOM sequence ESQ description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 33) chain D residue 216-218 type TOPO_DOM sequence WST description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 34) chain D residue 281-283 type TOPO_DOM sequence ESQ description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 35) chain E residue 216-218 type TOPO_DOM sequence WST description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3

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