eF-site ID 2xmr-ABC PDB Code 2xmr Chain A, B, C click to enlarge Title Crystal structure of human NDRG2 protein provides insight into its role as a tumor suppressor Classification SIGNALING PROTEIN Compound PROTEIN NDRG2 Source Homo sapiens (Human) (NDRG2_HUMAN) Sequence A:  AKTHSVETPYGSVTFTVYGTPAPARPAILTYHDVGLNYKS CFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQ YPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYAL NHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMI LGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSY NNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNSK LDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYM A B:  AKTHSVETPYGSVTFTVYGTPAPARPAILTYHDVGLNYKS CFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQ YPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYAL NHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMI LGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSY NNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNSK LDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYM A C:  AKTHSVETPYGSVTFTVYGTPAPARPAILTYHDVGLNYKS CFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQ YPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYAL NHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIPEMI LGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSY NNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVECNSK LDPTQTSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYM A Description Functional site 1) chain A residue 47 type sequence A description BINDING SITE FOR RESIDUE CA A 1305 source : AC1 2) chain A residue 302 type sequence Y description BINDING SITE FOR RESIDUE CA A 1305 source : AC1 3) chain C residue 47 type sequence A description BINDING SITE FOR RESIDUE CA A 1305 source : AC1 4) chain C residue 302 type sequence Y description BINDING SITE FOR RESIDUE CA A 1305 source : AC1 5) chain B residue 41 type sequence Y description BINDING SITE FOR RESIDUE ACT B 1305 source : AC2 6) chain B residue 61 type sequence Y description BINDING SITE FOR RESIDUE ACT B 1305 source : AC2 7) chain B residue 75 type sequence Q description BINDING SITE FOR RESIDUE ACT B 1305 source : AC2 8) chain B residue 83 type sequence R description BINDING SITE FOR RESIDUE ACT B 1305 source : AC2 9) chain B residue 85 type sequence H description BINDING SITE FOR RESIDUE ACT B 1305 source : AC2 10) chain C residue 41 type sequence Y description BINDING SITE FOR RESIDUE ACT C 1305 source : AC3 11) chain C residue 61 type sequence Y description BINDING SITE FOR RESIDUE ACT C 1305 source : AC3 12) chain C residue 69 type sequence F description BINDING SITE FOR RESIDUE ACT C 1305 source : AC3 13) chain C residue 75 type sequence Q description BINDING SITE FOR RESIDUE ACT C 1305 source : AC3 14) chain C residue 83 type sequence R description BINDING SITE FOR RESIDUE ACT C 1305 source : AC3 15) chain C residue 85 type sequence H description BINDING SITE FOR RESIDUE ACT C 1305 source : AC3 16) chain A residue 61 type sequence Y description BINDING SITE FOR RESIDUE ACT A 1306 source : AC4 17) chain A residue 75 type sequence Q description BINDING SITE FOR RESIDUE ACT A 1306 source : AC4 18) chain A residue 78 type sequence I description BINDING SITE FOR RESIDUE ACT A 1306 source : AC4 19) chain A residue 83 type sequence R description BINDING SITE FOR RESIDUE ACT A 1306 source : AC4 20) chain A residue 85 type sequence H description BINDING SITE FOR RESIDUE ACT A 1306 source : AC4 21) chain B residue 58 type sequence G description BINDING SITE FOR RESIDUE GOL B 1306 source : AC5 22) chain B residue 59 type sequence L description BINDING SITE FOR RESIDUE GOL B 1306 source : AC5 23) chain B residue 60 type sequence N description BINDING SITE FOR RESIDUE GOL B 1306 source : AC5 24) chain B residue 63 type sequence S description BINDING SITE FOR RESIDUE GOL B 1306 source : AC5 25) chain B residue 91 type sequence M description BINDING SITE FOR RESIDUE GOL B 1306 source : AC5 26) chain B residue 206 type sequence I description BINDING SITE FOR RESIDUE GOL B 1306 source : AC5 27) chain B residue 212 type sequence N description BINDING SITE FOR RESIDUE GOL B 1306 source : AC5 28) chain C residue 58 type sequence G description BINDING SITE FOR RESIDUE GOL C 1306 source : AC6 29) chain C residue 59 type sequence L description BINDING SITE FOR RESIDUE GOL C 1306 source : AC6 30) chain C residue 60 type sequence N description BINDING SITE FOR RESIDUE GOL C 1306 source : AC6 31) chain C residue 63 type sequence S description BINDING SITE FOR RESIDUE GOL C 1306 source : AC6 32) chain C residue 91 type sequence M description BINDING SITE FOR RESIDUE GOL C 1306 source : AC6 33) chain C residue 206 type sequence I description BINDING SITE FOR RESIDUE GOL C 1306 source : AC6 34) chain C residue 210 type sequence A description BINDING SITE FOR RESIDUE GOL C 1306 source : AC6 35) chain C residue 212 type sequence N description BINDING SITE FOR RESIDUE GOL C 1306 source : AC6 36) chain A residue 58 type sequence G description BINDING SITE FOR RESIDUE GOL A 1307 source : AC7 37) chain A residue 59 type sequence L description BINDING SITE FOR RESIDUE GOL A 1307 source : AC7 38) chain A residue 60 type sequence N description BINDING SITE FOR RESIDUE GOL A 1307 source : AC7 39) chain A residue 63 type sequence S description BINDING SITE FOR RESIDUE GOL A 1307 source : AC7 40) chain A residue 91 type sequence M description BINDING SITE FOR RESIDUE GOL A 1307 source : AC7 41) chain A residue 206 type sequence I description BINDING SITE FOR RESIDUE GOL A 1307 source : AC7 42) chain A residue 210 type sequence A description BINDING SITE FOR RESIDUE GOL A 1307 source : AC7 43) chain A residue 212 type sequence N description BINDING SITE FOR RESIDUE GOL A 1307 source : AC7

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