eF-site ID 2xkw-B PDB Code 2xkw Chain B click to enlarge Title LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST PIOGLITAZONE Classification TRANSCRIPTION Compound PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA Source (PPARG_HUMAN) Sequence B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSP FVIYDMNSLMMGEDKIKFKHITEVAIRIFQGCQFRSVEAV QEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASL MNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVK FNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNL LQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLL QVIKKTEHPLLQEIYK Description Functional site 1) chain B residue 312 type sequence N description BINDING SITE FOR RESIDUE PE4 A 1479 source : AC2 2) chain B residue 249 type sequence I description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 3) chain B residue 255 type sequence L description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 4) chain B residue 259 type sequence E description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 5) chain B residue 264 type sequence F description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 6) chain B residue 266 type sequence H description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 7) chain B residue 280 type sequence R description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 8) chain B residue 281 type sequence I description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 9) chain B residue 285 type sequence C description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 10) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 11) chain B residue 292 type sequence A description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 12) chain B residue 330 type sequence L description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 13) chain B residue 341 type sequence I description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 14) chain B residue 348 type sequence M description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 15) chain B residue 364 type sequence M description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 16) chain B residue 236 type sequence I description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 17) chain B residue 237 type sequence L description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 18) chain B residue 245 type sequence S description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 19) chain B residue 247 type sequence F description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 20) chain B residue 248 type sequence V description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 21) chain B residue 257 type sequence M description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 22) chain B residue 335 type sequence N description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 23) chain B residue 347 type sequence F description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 24) chain B residue 314 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 25) chain B residue 351 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 26) chain B residue 252 type CROSSLNK sequence M description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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