eF-site ID 2xkw-AB PDB Code 2xkw Chain A, B click to enlarge Title LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST PIOGLITAZONE Classification TRANSCRIPTION Compound PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA Source (PPARG_HUMAN) Sequence A:  LNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTD KSPFVIYDMNSLMMGEDKKEVAIRIFQGCQFRSVEAVQEI TEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNK DGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNA LELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQA LELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVI KKTETDMSLHPLLQEIYKDLY B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSP FVIYDMNSLMMGEDKIKFKHITEVAIRIFQGCQFRSVEAV QEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASL MNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVK FNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNL LQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLL QVIKKTEHPLLQEIYK Description Functional site 1) chain A residue 255 type sequence L description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 2) chain A residue 259 type sequence E description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 3) chain A residue 282 type sequence F description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 4) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 5) chain A residue 286 type sequence Q description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 6) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 7) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 8) chain A residue 292 type sequence A description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 9) chain A residue 323 type sequence H description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 10) chain A residue 326 type sequence I description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 11) chain A residue 327 type sequence Y description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 12) chain A residue 330 type sequence L description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 13) chain A residue 341 type sequence I description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 14) chain A residue 364 type sequence M description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 15) chain A residue 449 type sequence H description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 16) chain A residue 469 type sequence L description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 17) chain A residue 473 type sequence Y description BINDING SITE FOR RESIDUE P1B A 1478 source : AC1 18) chain A residue 232 type sequence K description BINDING SITE FOR RESIDUE PE4 A 1479 source : AC2 19) chain A residue 239 type sequence G description BINDING SITE FOR RESIDUE PE4 A 1479 source : AC2 20) chain A residue 240 type sequence K description BINDING SITE FOR RESIDUE PE4 A 1479 source : AC2 21) chain A residue 241 type sequence T description BINDING SITE FOR RESIDUE PE4 A 1479 source : AC2 22) chain A residue 242 type sequence T description BINDING SITE FOR RESIDUE PE4 A 1479 source : AC2 23) chain A residue 243 type sequence D description BINDING SITE FOR RESIDUE PE4 A 1479 source : AC2 24) chain A residue 244 type sequence K description BINDING SITE FOR RESIDUE PE4 A 1479 source : AC2 25) chain B residue 312 type sequence N description BINDING SITE FOR RESIDUE PE4 A 1479 source : AC2 26) chain B residue 249 type sequence I description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 27) chain B residue 255 type sequence L description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 28) chain B residue 259 type sequence E description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 29) chain B residue 264 type sequence F description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 30) chain B residue 266 type sequence H description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 31) chain B residue 280 type sequence R description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 32) chain B residue 281 type sequence I description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 33) chain B residue 285 type sequence C description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 34) chain B residue 288 type sequence R description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 35) chain B residue 292 type sequence A description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 36) chain B residue 330 type sequence L description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 37) chain B residue 341 type sequence I description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 38) chain B residue 348 type sequence M description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 39) chain B residue 364 type sequence M description BINDING SITE FOR RESIDUE P1B B 1475 source : AC3 40) chain B residue 236 type sequence I description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 41) chain B residue 237 type sequence L description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 42) chain B residue 245 type sequence S description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 43) chain B residue 247 type sequence F description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 44) chain B residue 248 type sequence V description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 45) chain B residue 257 type sequence M description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 46) chain B residue 335 type sequence N description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 47) chain B residue 347 type sequence F description BINDING SITE FOR RESIDUE EPE B 1476 source : AC4 48) chain A residue 314 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 49) chain A residue 351 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 50) chain A residue 477 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 51) chain B residue 314 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 52) chain B residue 351 type BINDING sequence E description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 53) chain A residue 252 type CROSSLNK sequence M description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 54) chain B residue 252 type CROSSLNK sequence M description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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