eF-site ID 2xkw-AB
PDB Code 2xkw
Chain A, B

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Title LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST PIOGLITAZONE
Classification TRANSCRIPTION
Compound PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
Source (PPARG_HUMAN)
Sequence A:  LNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTD
KSPFVIYDMNSLMMGEDKKEVAIRIFQGCQFRSVEAVQEI
TEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNK
DGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNA
LELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQA
LELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVI
KKTETDMSLHPLLQEIYKDLY
B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSP
FVIYDMNSLMMGEDKIKFKHITEVAIRIFQGCQFRSVEAV
QEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASL
MNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVK
FNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNL
LQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLL
QVIKKTEHPLLQEIYK
Description


Functional site

1) chain A
residue 255
type
sequence L
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

2) chain A
residue 259
type
sequence E
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

3) chain A
residue 282
type
sequence F
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

4) chain A
residue 285
type
sequence C
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

5) chain A
residue 286
type
sequence Q
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

6) chain A
residue 288
type
sequence R
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

7) chain A
residue 289
type
sequence S
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

8) chain A
residue 292
type
sequence A
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

9) chain A
residue 323
type
sequence H
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

10) chain A
residue 326
type
sequence I
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

11) chain A
residue 327
type
sequence Y
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

12) chain A
residue 330
type
sequence L
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

13) chain A
residue 341
type
sequence I
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

14) chain A
residue 364
type
sequence M
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

15) chain A
residue 449
type
sequence H
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

16) chain A
residue 469
type
sequence L
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

17) chain A
residue 473
type
sequence Y
description BINDING SITE FOR RESIDUE P1B A 1478
source : AC1

18) chain A
residue 232
type
sequence K
description BINDING SITE FOR RESIDUE PE4 A 1479
source : AC2

19) chain A
residue 239
type
sequence G
description BINDING SITE FOR RESIDUE PE4 A 1479
source : AC2

20) chain A
residue 240
type
sequence K
description BINDING SITE FOR RESIDUE PE4 A 1479
source : AC2

21) chain A
residue 241
type
sequence T
description BINDING SITE FOR RESIDUE PE4 A 1479
source : AC2

22) chain A
residue 242
type
sequence T
description BINDING SITE FOR RESIDUE PE4 A 1479
source : AC2

23) chain A
residue 243
type
sequence D
description BINDING SITE FOR RESIDUE PE4 A 1479
source : AC2

24) chain A
residue 244
type
sequence K
description BINDING SITE FOR RESIDUE PE4 A 1479
source : AC2

25) chain B
residue 312
type
sequence N
description BINDING SITE FOR RESIDUE PE4 A 1479
source : AC2

26) chain B
residue 249
type
sequence I
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

27) chain B
residue 255
type
sequence L
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

28) chain B
residue 259
type
sequence E
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

29) chain B
residue 264
type
sequence F
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

30) chain B
residue 266
type
sequence H
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

31) chain B
residue 280
type
sequence R
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

32) chain B
residue 281
type
sequence I
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

33) chain B
residue 285
type
sequence C
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

34) chain B
residue 288
type
sequence R
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

35) chain B
residue 292
type
sequence A
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

36) chain B
residue 330
type
sequence L
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

37) chain B
residue 341
type
sequence I
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

38) chain B
residue 348
type
sequence M
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

39) chain B
residue 364
type
sequence M
description BINDING SITE FOR RESIDUE P1B B 1475
source : AC3

40) chain B
residue 236
type
sequence I
description BINDING SITE FOR RESIDUE EPE B 1476
source : AC4

41) chain B
residue 237
type
sequence L
description BINDING SITE FOR RESIDUE EPE B 1476
source : AC4

42) chain B
residue 245
type
sequence S
description BINDING SITE FOR RESIDUE EPE B 1476
source : AC4

43) chain B
residue 247
type
sequence F
description BINDING SITE FOR RESIDUE EPE B 1476
source : AC4

44) chain B
residue 248
type
sequence V
description BINDING SITE FOR RESIDUE EPE B 1476
source : AC4

45) chain B
residue 257
type
sequence M
description BINDING SITE FOR RESIDUE EPE B 1476
source : AC4

46) chain B
residue 335
type
sequence N
description BINDING SITE FOR RESIDUE EPE B 1476
source : AC4

47) chain B
residue 347
type
sequence F
description BINDING SITE FOR RESIDUE EPE B 1476
source : AC4

48) chain A
residue 314
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

49) chain A
residue 351
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

50) chain A
residue 477
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

51) chain B
residue 314
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

52) chain B
residue 351
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

53) chain A
residue 252
type CROSSLNK
sequence M
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
source Swiss-Prot : SWS_FT_FI2

54) chain B
residue 252
type CROSSLNK
sequence M
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
source Swiss-Prot : SWS_FT_FI2


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